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Melero-Martin Lab - Publications

see all publications in PubMed


Microfluidic capture of endothelial colony-forming cells from human adult peripheral blood: phenotypic and functional validation in vivo. Lin RZ, Hatch A, Antontsev VG, Murthy SK, Melero-Martin JMTissue Eng Part C Methods 2014; in press.

Human endothelial colony-forming cells serve as trophic mediators for mesenchymal stem cell engraftment via paracrine signaling. Lin RZ, Moreno-Luna R, Li D, Jaminet SCS, Greene AK, Melero-Martin JM.  Proc Natl Acad Sci USA 2014; 111(28):10137-10142.

Decreased level of cord blood circulating endothelial colony-forming cells in preeclampsia. Muñoz-Hernandez R, Miranda ML, Stiefel P, Lin RZ, Praena-Fernandez JM, Dominguez-Simeon MJ, Villar J, Moreno-Luna R, Melero-Martin JMHypertension 2014; 64(1):165-171.

Maternal body-mass index and cord blood circulating endothelial colony-forming cells. Moreno-Luna R*, Muñoz-Hernandez R*, Lin RZ, Miranda ML, Vallejo-Vaz AJ, Stiefel P, Praena-Fernandez JM, Bernal-Bermejo J, Jimenez-Jimenez LM, Villar J, Melero-Martin JM.  J Pediatr 2014; 164(3):566-71. (*co-first authors)


TM4SF1: a new vascular therapeutic target in cancer. Lin CL, Merley A, Sciuto TE, Li D, Dvorak AM, Melero-Martin JM, Dvorak HF, Jaminet SCSAngiogenesis 2014; 17(4):897-907.

Epicardium-to-fat transition in injured heart. Liu Q, Huang X, Oh JH, Lin RZ, Duan S, Yu Y, Yang R, Qiu J, Melero-MArtin JM, Pu WT, Zhou BCell Res 2014; in press.

Vascular channels formed by subpopulations of PECAM+ melanoma cells. Dunleavey JM, Xiao L, Thompson J, Kim MM, Shields J, Shelton SE, Irvin DM, Brings BE, Ollila D, Brekken RA, Dayton PA, Melero-Martin JM, Dudley ACNat Commun 2014; in press.


Transdermal regulation of vascular network bioengineering using a photopolymerizable methacrylated gelatin hydrogel. Lin RZ, Chen YC, Moreno-Luna R, Khademhosseini A, Melero-Martin JM.  Biomaterials 2013; 34(28):6785-96.

Human white adipose tissue vasculature contains endothelial colony-forming cells with robust in vivo vasculogenic potential. Lin RZ*, Moreno-Luna R*, Muñoz-Hernandez R, Li D, Jaminet SC, Greene AK, Melero-Martin JMAngiogenesis 2013; 34(28):6785-96. (*co-first authors)


Equal modulation of endothelial cell function by four distinct tissue-specific mesenchymal stem cells. Lin RZ, Moreno-Luna R, Zhou B, Pu WT, Melero-Martin JMAngiogenesis 2012; 15(3):443-55. 

Fibroblast growth factor-2 facilitates rapid anastomosis formation between bioengineered human vascular networks and living vasculature. Lin RZ, Melero-Martin JMMethods 2012; 56(3):440-51. 

Functional human vascular network generated in photocrosslinkable gelatin methacrylate hydrogels. Chen YC*, Lin RZ*, Qi H, Yang Y, Bae H, Melero-Martin JM, Khademhosseini AAdv Funct Mater 2012; 22(10):2027-39. (*co-first authors) 


Thymosin beta 4 treatment after myocardial infarction does not reprogram epicardial cells into cardiomyocytes. Zhou B, Honor LB, Ma Q, Oh JH, Lin RZ, Melero-Martin JM, von Gise A, Zhou P, Hu T, He L, Wu KH, Zhang H, Zhang Y, Pu WT.  J Mol Cell Cardiol 2012; 52(1):43-7.

Inflamed tumor-associated adipose tissue is a depot for macrophages that stimulate tumor growth and angiogenesis. Wagner M, Bjerkvig R, Wiig H,  Melero-Martin JM, Lin RZ, Klagsbrun M, Dudley ACAngiogenesis 2012; 15(3):481-95.


Induction of erythropoiesis using human vascular networks genetically-engineered for controlled erythropoietin release. Lin RZ, Dreyzin A, Aamodt K, Li D, Jaminet SC, Dudley AC, Melero-Martin JM.  Blood 2011; 118(20):5420-8. 

Bioengineering human microvascular networks in immunodeficient mice. Lin RZ, Melero-Martin JM.  J Vis Exp 2011; Jul 11;(53).pii:3065 .

Concise review: vascular stem cells and tumor angiogenesis. Melero-Martin JM, Dudley AC. Stem Cells 2011; 29:163-8.

Functional endothelial progenitor cells from cryopreserved umbilical cord blood. Lin RZ, Dreyzin A, Aamodt K, Dudley AC, Melero-Martin JM. Cell Transplant 2011; 20:515-522.


Adult mouse epicardium modulates myocardial injury by secreting paracrine factors. Zhou B, Honor LB, He H, Ma Q, Oh JH, Butterfield C, Lin RZ, Melero-Martin JM, Dolmatova E, Duffy HS, Gise AV, Zhou P, Hu YW, Wang G, Zhang B, Wang L, Hall JL, Moses MA, McGowan FX, Pu WTJ Clin Invest 2011; 121:1894-1904.

Type I collagen, fibrin and Puamatrix matrices provide permissive environments for human endothelial and mesenchymal progenitor cells to form neovascular networks. Allen P, Melero-Martin JM, Bischoff JJ Tissue Eng Regen Med 2011; Apr 5(4):e74-86.


Host myeloid cells are necessary for creating bio-engineered human vascular networks in vivo. Melero-Martin JM, De Obaldia ME, Allen P, Dudley AC, Klagsbrun M, Bischoff J. Tissue Eng Part A 2010; 16:2457-2466.

Bone marrow is a reservoir for pro-angiogenic myelomonocytic cells but not endothelial cells in spontaneous tumors. Dudley AC, Udagawa T, Melero-Martin JM, Shih SC, Curatolo A, Moses M, Klagsbrun M. Blood 2010; 116:3367-3371.

In vivo monitoring of autologous engineered pulmonary valve function. Gottlieb D, Tandon K, Emani S, Aikawa E, Brown DW, Powell AJ, Nedder A, Engelmayr GC, Melero-Martin JM, Sacks MS, Mayer JE Jr. J Thorac Cardiovasc Surg 2010; 139:723-731.

Intravital molecular imaging of small-diameter tissue-engineered vascular grafts in mice: a feasibility study. Hjortnaes J, Gottlieb D, Figueiredo JL, Melero-Martin JM, Kohler RH, Bischoff J, Weissleder R, Mayer, J, Aikawa E. Tissue Eng Part C Methods 2010; 16:597-607.

Methodology for optimal in vitro cell expansion in tissue engineering. Melero-Martin JM, Santhalingam S, Al-Rubeai M.  Adv Biochem Eng Biotechnol 2009; 112:209-29.

Engineering robust and functional vascular networks in vivo with human adult and cord blood-derived progenitor cells. Melero-Martin JM, De Obaldia ME, Kang S-Y, Khan ZA, Yuan L, Oettgen P, Bischoff J. Circ Res 2008; 103:194-202. Editorial commentary   Best paper award 2009  - 

Chapter 13: An in vivo experimental model for postnatal vasculogenesis. Melero-Martin JM, Bischoff J. Methods Enzymol 2008; 445:303-329.

Multipotential stem cells recapitulate human infantile hemangioma in immunodeficient mice. Khan ZA*, Boscolo E*, Picard A, Psutka S, Melero-Martin JM, Bartch TC, Mulliken JB, Bischoff J. J Clin Invest 2008; 118: 2592-2599.

In vivo vasculogenic potential of human blood-derived endothelial progenitor cells. Melero-Martin JM, Khan ZA, Picard A, Wu X, Paruchuri S, Bischoff J. Blood 2007; 109:4761-4768.

Human pulmonary valve progenitor cells exhibit endothelial/mesenchymal plasticity in response to vascular endothelial growth factor-A and transforming growth factor-beta2. Paruchuri S, Yang JH, Rabkin-Aikawa E, Melero-Martin JM, Khan ZA, Loukogeorgakis S, Schoen FJ, Bischoff J.  Circ Res 2006; 99:861-869.

Endothelial progenitor cells from infantile hemangioma and umbilical cord blood display unique cellular responses to Endostatin.  Khan ZA, Melero-Martin JM, Wu X, Paruchuri S, Boscolo E, Mulliken JB, Bischoff J. Blood 2006; 108:915-921.

Expansion of chondroprogenitor cells on macroporous microcarriers as an alternative to conventional monolayer systems. Melero-Martin JM, Dowling MA, Smith M, Al-Rubeai M. Biomaterials 2006; 27:2970-2979.

Optimal in-vitro expansion of chondroprogenitor cells in monolayer culture. Melero-Martin JM, Dowling MA, Smith M, Al-Rubeai M. Biotechnol Bioeng 2006; 93:519-533.

Cryopreservation and in-vitro expansion of chondroprogenitor cells isolated from the superficial zone of articular cartilage. Martin JM, Smith M, Al-Rubeai M. Biotechnol Prog 2005; 21:168-177.


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