Research

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Melero-Martin Lab - Publications

see all publications in PubMed


2015


Microfluidic capture of endothelial colony-forming cells from human adult peripheral blood: phenotypic and functional validation in vivo 

Lin RZ, Hatch A, Antontsev VG, Murthy SK, Melero-Martin JM 

Tissue Eng Part C Methods 2015; 21(3):274-83


Collaborations:

Enzymatic regulation of functional vascular networks using gelatin hydrogels 

Chuang CH, Lin RZ, Tien HW, Chu YC, Li YC, Melero-Martin JM, Chen YC 

Acta Biomater 2015; Jun;19:85-99



2014


Human endothelial colony-forming cells serve as trophic mediators for mesenchymal stem cell engraftment via paracrine signaling 

Lin RZ, Moreno-Luna R, Li D, Jaminet SCS, Greene AK, Melero-Martin JM.  

Proc Natl Acad Sci USA 2014; 111(28):10137-10142 


Decreased level of cord blood circulating endothelial colony-forming cells in preeclampsia

Muñoz-Hernandez R, Miranda M, Stiefel P, Lin RZ, Praena-Fernandez J, Dominguez-Simeon M, Villar J, Moreno-Luna R, Melero-Martin JM 

Hypertension 2014; 64(1):165-171 - Editorial commentary


Maternal body-mass index and cord blood circulating endothelial colony-forming cells 

Moreno-Luna R*, Muñoz-Hernandez R*, Lin RZ, Miranda ML, Vallejo-Vaz AJ, Stiefel P, Praena-Fernandez JM, Bernal-Bermejo J, Jimenez-Jimenez LM, Villar J, Melero-Martin JM (*co-first authors)  

J Pediatr 2014; 164(3):566-71 - Editorial commentary 


Collaborations:

TM4SF1: a new vascular therapeutic target in cancer 

Lin CL, Merley A, Sciuto TE, Li D, Dvorak AM, Melero-Martin JM, Dvorak HF, Jaminet SCS 

Angiogenesis 2014; 17(4):897-907


Epicardium-to-fat transition in injured heart 

Liu Q, Huang X, Oh JH, Lin RZ, Duan S, Yu Y, Yang R, Qiu J, Melero-MArtin JM, Pu WT, Zhou B 

Cell Res 2014; 24(11):1367-9


Vascular channels formed by subpopulations of PECAM+ melanoma cells 

Dunleavey JM, Xiao L, Thompson J, Kim MM, Shields J, Shelton SE, Irvin DM, Brings BE, Ollila D, Brekken RA, Dayton PA, Melero-Martin JM, Dudley AC 

Nat Commun 2014; Oct 22;5:5200




2013


Transdermal regulation of vascular network bioengineering using a photopolymerizable methacrylated gelatin hydrogel 

Lin RZ, Chen YC, Moreno-Luna R, Khademhosseini A, Melero-Martin JM  

Biomaterials 2013; 34(28):6785-96


Human white adipose tissue vasculature contains endothelial colony-forming cells with robust in vivo vasculogenic potential 

Lin RZ*, Moreno-Luna R*, Muñoz-Hernandez R, Li D, Jaminet SC, Greene AK, Melero-Martin JM (*co-first authors) 

Angiogenesis 2013; 34(28):6785-96 



2012


Equal modulation of endothelial cell function by four distinct tissue-specific mesenchymal stem cells 

Lin RZ, Moreno-Luna R, Zhou B, Pu WT, Melero-Martin JM 

Angiogenesis 2012; 15(3):443-55

 

Fibroblast growth factor-2 facilitates rapid anastomosis formation between bioengineered human vascular networks and living vasculature 

Lin RZ, Melero-Martin JM 

Methods 2012; 56(3):440-51

 

Functional human vascular network generated in photocrosslinkable gelatin methacrylate hydrogels 

Chen YC*, Lin RZ*, Qi H, Yang Y, Bae H, Melero-Martin JM, Khademhosseini A (*co-first authors) 

Adv Funct Mater 2012; 22(10):2027-39 


Collaborations:

Thymosin beta 4 treatment after myocardial infarction does not reprogram epicardial cells into cardiomyocytes 

Zhou B, Honor LB, Ma Q, Oh JH, Lin RZ, Melero-Martin JM, von Gise A, Zhou P, Hu T, He L, Wu KH, Zhang H, Zhang Y, Pu WT  

J Mol Cell Cardiol 2012; 52(1):43-7


Inflamed tumor-associated adipose tissue is a depot for macrophages that stimulate tumor growth and angiogenesis 

Wagner M, Bjerkvig R, Wiig H,  Melero-Martin JM, Lin RZ, Klagsbrun M, Dudley AC

Angiogenesis 2012; 15(3):481-95




2011


Induction of erythropoiesis using human vascular networks genetically-engineered for controlled erythropoietin release 

Lin RZ, Dreyzin A, Aamodt K, Li D, Jaminet SC, Dudley AC, Melero-Martin JM

Blood 2011; 118(20):5420-8

 

Bioengineering human microvascular networks in immunodeficient mice 

Lin RZ, Melero-Martin JM  

J Vis Exp 2011; Jul 11;(53).pii:3065


Concise review: vascular stem cells and tumor angiogenesis 

Melero-Martin JM, Dudley AC 

Stem Cells 2011; 29:163-8


Functional endothelial progenitor cells from cryopreserved umbilical cord blood 

Lin RZ, Dreyzin A, Aamodt K, Dudley AC, Melero-Martin JM 

Cell Transplant 2011; 20:515-522


Collaborations:

Adult mouse epicardium modulates myocardial injury by secreting paracrine factors 

Zhou B, Honor LB, He H, Ma Q, Oh JH, Butterfield C, Lin RZ, Melero-Martin JM, Dolmatova E, Duffy HS, Gise AV, Zhou P, Hu YW, Wang G, Zhang B, Wang L, Hall JL, Moses MA, McGowan FX, Pu WT 

J Clin Invest 2011; 121:1894-1904


Type I collagen, fibrin and Puamatrix matrices provide permissive environments for human endothelial and mesenchymal progenitor cells to form neovascular networks 

Allen P, Melero-Martin JM, Bischoff J 

J Tissue Eng Regen Med 2011; Apr 5(4):e74-86




2005-2010


Host myeloid cells are necessary for creating bio-engineered human vascular networks in vivo 

Melero-Martin JM, De Obaldia ME, Allen P, Dudley AC, Klagsbrun M, Bischoff J 

Tissue Eng Part A 2010; 16:2457-2466


Bone marrow is a reservoir for pro-angiogenic myelomonocytic cells but not endothelial cells in spontaneous tumors 

Dudley AC, Udagawa T, Melero-Martin JM, Shih SC, Curatolo A, Moses M, Klagsbrun M 

Blood 2010; 116:3367-3371


In vivo monitoring of autologous engineered pulmonary valve function 

Gottlieb D, Tandon K, Emani S, Aikawa E, Brown DW, Powell AJ, Nedder A, Engelmayr GC, Melero-Martin JM, Sacks MS, Mayer JE Jr 

J Thorac Cardiovasc Surg 2010; 139:723-731


Intravital molecular imaging of small-diameter tissue-engineered vascular grafts in mice: a feasibility study 

Hjortnaes J, Gottlieb D, Figueiredo JL, Melero-Martin JM, Kohler RH, Bischoff J, Weissleder R, Mayer, J, Aikawa E 

Tissue Eng Part C Methods 2010; 16:597-607


Methodology for optimal in vitro cell expansion in tissue engineering 

Melero-Martin JM, Santhalingam S, Al-Rubeai M  

Adv Biochem Eng Biotechnol 2009; 112:209-29


Engineering robust and functional vascular networks in vivo with human adult and cord blood-derived progenitor cells 

Melero-Martin JM, De Obaldia ME, Kang S-Y, Khan ZA, Yuan L, Oettgen P, Bischoff J 

Circ Res 2008; 103:194-202. Editorial commentary  -  Best paper award 2009

  

Chapter 13: An in vivo experimental model for postnatal vasculogenesis 

Melero-Martin JM, Bischoff J 

Methods Enzymol 2008; 445:303-329


Multipotential stem cells recapitulate human infantile hemangioma in immunodeficient mice

Khan ZA*, Boscolo E*, Picard A, Psutka S, Melero-Martin JM, Bartch TC, Mulliken JB, Bischoff J 

J Clin Invest 2008; 118: 2592-2599


In vivo vasculogenic potential of human blood-derived endothelial progenitor cells 

Melero-Martin JM, Khan ZA, Picard A, Wu X, Paruchuri S, Bischoff J 

Blood 2007; 109:4761-4768


Human pulmonary valve progenitor cells exhibit endothelial/mesenchymal plasticity in response to vascular endothelial growth factor-A and transforming growth factor-beta2 

Paruchuri S, Yang JH, Rabkin-Aikawa E, Melero-Martin JM, Khan ZA, Loukogeorgakis S, Schoen FJ, Bischoff J  

Circ Res 2006; 99:861-869


Endothelial progenitor cells from infantile hemangioma and umbilical cord blood display unique cellular responses to Endostatin  

Khan ZA, Melero-Martin JM, Wu X, Paruchuri S, Boscolo E, Mulliken JB, Bischoff J 

Blood 2006; 108:915-921


Expansion of chondroprogenitor cells on macroporous microcarriers as an alternative to conventional monolayer systems 

Melero-Martin JM, Dowling MA, Smith M, Al-Rubeai M 

Biomaterials 2006; 27:2970-2979


Optimal in-vitro expansion of chondroprogenitor cells in monolayer culture 

Melero-Martin JM, Dowling MA, Smith M, Al-Rubeai M 

Biotechnol Bioeng 2006; 93:519-533


Cryopreservation and in-vitro expansion of chondroprogenitor cells isolated from the superficial zone of articular cartilage 

Martin JM, Smith M, Al-Rubeai M 

Biotechnol Prog 2005; 21:168-177












2013


Transdermal regulation of vascular network bioengineering using a photopolymerizable methacrylated gelatin hydrogel 

Lin RZ, Chen YC, Moreno-Luna R, Khademhosseini A, Melero-Martin JM  

Biomaterials 2013; 34(28):6785-96

Human white adipose tissue vasculature contains endothelial colony-forming cells with robust in vivo vasculogenic potential 

Lin RZ*, Moreno-Luna R*, Muñoz-Hernandez R, Li D, Jaminet SC, Greene AK, Melero-Martin JM (*co-first authors) 

Angiogenesis 2013; 34(28):6785-96 




2013


Transdermal regulation of vascular network bioengineering using a photopolymerizable methacrylated gelatin hydrogel 

Lin RZ, Chen YC, Moreno-Luna R, Khademhosseini A, Melero-Martin JM  

Biomaterials 2013; 34(28):6785-96

Human white adipose tissue vasculature contains endothelial colony-forming cells with robust in vivo vasculogenic potential 

Lin RZ*, Moreno-Luna R*, Muñoz-Hernandez R, Li D, Jaminet SC, Greene AK, Melero-Martin JM (*co-first authors) 

Angiogenesis 2013; 34(28):6785-96 





2013


Transdermal regulation of vascular network bioengineering using a photopolymerizable methacrylated gelatin hydrogel 

Lin RZ, Chen YC, Moreno-Luna R, Khademhosseini A, Melero-Martin JM  

Biomaterials 2013; 34(28):6785-96

Human white adipose tissue vasculature contains endothelial colony-forming cells with robust in vivo vasculogenic potential 

Lin RZ*, Moreno-Luna R*, Muñoz-Hernandez R, Li D, Jaminet SC, Greene AK, Melero-Martin JM (*co-first authors) 

Angiogenesis 2013; 34(28):6785-96 




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