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Melero-Martin Laboratory

We are a cell biology and bioengineering laboratory within the Department of Cardiac Surgery at Boston Children's Hospital. We are affiliated with the Harvard Medical SchoolWe specialize in the biology and therapeutic potential of human Endothelial Progenitor Cells (EPCs) and Endothelial Colony-Forming Cells (ECFCs).

Research Overview

Stem cells and tissue engineering hold great promise in Regenerative Medicine. However, engrafting stem cells and generating tissues with stable functional vascular beds remain major challenges. Our laboratory is interested in understanding how vascular networks are formed and  the mechanisms by which the vasculature modulates the activity of various human stem cells. Current projects in the lab are focused on:

  • Endothelial colony-forming cells (ECFCs)
  • Bioengineering vascular networks
  • Vascular regulation of mesenchymal stem cell activity
  • Genetically-engineered vasculature for protein drug delivery

Adventures in gene therapy: Getting your own blood vessels to make drugs
June 18, 2014. Juan Melero-Martin, VECTOR blog


Selected Publications

Human endothelial colony-forming cells serve as trophic mediators for mesenchymal stem cell engraftment via paracrine signaling
Lin RZ, Moreno-Luna R, Li D, Jaminet SCS, Greene AK, Melero-Martin JM
Proc Natl Acad Sci USA 2014; 111(28):10137-10142

Transdermal regulation of vascular network bioengineering using a photopolymerizable methacrylated gelatin hydrogel
Lin RZ, Chen YC, Moreno-Luna R, Khademhosseini A, Melero-Martin JM
Biomaterials 2013; 34(28):6785-96

Induction of erythropoiesis using human vascular networks genetically-engineered for controlled erythropoietin release
Lin RZ, Dreyzin A, Aamodt K, Li D, Jaminet SC, Dudley AC, Melero-Martin JM
Blood 2011; 118(20):5420-8

See all publications...

Lab News

HSCI/Children's researcher wins prestigious Bayer Hemophilia Award
May 19, 2014. Harvard Stem Cell Institute (HSCI)

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