Dr. Carla Kim
Dr. Carla Kim is a Principal Investigator at Boston Children’s Hospital and an Associate Professor in the Department of Genetics at Harvard medical School. Her laboratory is interested in the relationships between stem cell biology, cancer biology, and lung biology.
Carla earned her doctorate in Genetics at the University of Wisconsin, Madison. As a graduate student in the laboratory of John Petrini, she had studied the role of the Rad50 gene in DNA damage responses and homeostasis in vivo. She found that a point mutation in the murine Rad50 gene led to bone marrow failure (likely due to hematopoietic stem cell failure) as well as increased susceptibility to hematopoietic malignancy.
These studies stimulated her interest in determining if stem cells played a role in the initiation of cancer. She went on to a postdoctoral position in the laboratory of Tyler Jacks at the Massachusetts Institute of Technology Center for Cancer Research. There she developed a method to isolate the first stem cell population from the adult murine lung, termed bronchioalveolar stem cells (BASCs). She also showed that BASCs are critically affected by an oncogenic K-ras mutation and may be the cell-of-origin of lung adenocarcinomas. Carla Kim joined the Stem Cell Program at Children’s Hospital Boston and established her laboratory in September 2006.
Christine Fillmore, PhD
Chris is interested in elucidating epigenetic mechanisms that control lung cancer subtype and disease resistance. She studied microbiology at Middlebury College and became interested in cancer genetics while working at Dana-Farber Cancer Institute as a technician. She then earned her Ph.D. at Tufts University Sackler School where she studied breast cancer stem cells
Kristen Leeman, MD
Kristen is a board certified Pediatrician and Instructor in Pediatrics at Harvard Medical School. She received her BS with Honors in Chemistry from University of North Carolina at Chapel Hill. She received her MD from the University of Virginia and completed pediatric residency training at University of North Carolina Children's Hospital. Kristen joined the lab in July 2010 and is interested in studying the role of BASCs in physiologic lung development and lung injury.
Samuel Rowbotham, PhD
Sam received his Bsc in Genetics from the University of York in 2007. He then received his PhD from the University of Cambridge in 2011 for his work on the role of chromatin remodeling proteins in the replication of epigenetic modifications. Sam joined the lab in December 2011 and is studying the relationship between the epigenetic control of self-renewal and differentiation of lung stem cells and lung cancer stem cells.
Carolina Garcia de Alba Rivas, MD PhD
Carolina received her MD from the Universidad Autonoma de Baja California in Mexicali, she has a Masters degree in Epidemiology and received her PhD in biomedical sciences from the Universidad Nacional Autonoma de Mexico where she studied the participation of hematopoietic progenitor cells in the pathogenesis of Idiopathic Pulmonary Fibrosis, under the mentorship of Dr. Moises Selman. She joined the Kim lab in April 2014 and is interested in studying the effect of chronic epithelial injury on the regenerative capacity of endogenous lung stem and progenitor cells.
Lisa Li, PhD
Lisa received her mastesr degree from Nagoya Institute of Technology and her Ph.D. from Shinya Yamanaka’s lab in Kyoto University, Japan. Her graduate studies focused on developing novel technologies to genetically engineer stem cells for gene therapy. She joined the Kim lab and the Daley lab in July 2015 and is studying targets for cystic fibrosis using stem cell and gene editing technologies.
Margherita Paschini, PhD
Margherita received her bachelor and master degrees in Molecular Biotechnology from the University of Bologna, Italy. She then obtained her PhD from the University of California, San Diego working on the replication of yeast telomeres at the Salk Institute in La Jolla, California. She joined the Kim lab in August 2015 and she is currently focused on the paracrine signaling occurring in the pulmonary niche after injury and during cancer progression.
Kelly joined the Kim Lab in October of 2012. She graduated from Boston College with a degree in Biology.
Bryan joined the Kim Lab in September of 2015. He graduated from Weslyan University with a degree in Biology.
Riley joined the Kim Lab in June 2014. Riley provides coordination and administrative support for the Kim Lab. If you are interested in learning more about the Kim Lab, or receiving copies of Kim Lab papers, please email Riley.