The broad interest of the Kim Lab is to characterize the biology of stem cells in normal lung and lung cancer. Numerous lung diseases such as cystic fibrosis or chronic obstructive pulmonary disease involve injured or depleted bronchiolar or alveolar epithelium. Bronchiolar and alveolar cells are also affected in adenocarcinoma, the most common form of lung cancer. It is likely that lung stem cells are critically affected in patients with these devastating diseases.
Our long-term goal is to elucidate the role of stem cells in lung homeostasis as a prerequisite to the development of therapeutic strategies that can be used to prevent or attenuate lung disease. We use a combination of mouse genetics, cell biology, and genomics approaches to elucidate the biology of lung stem cells during homeostasis and disease.
For more information, go to http://kim.tchlab.org/
Fillmore CM, Xu C, Desai PT, Berry JM, Rowbotham SP, Lin YJ, Zhang H, Marquez VE, Hammerman PS, Wong KK, Kim CF. 2015. EZH2 inhibition sensitizes BRG1 and EGFR mutant lung tumors to TopoII inhibitors. Nature. 520(7546):239-42. PMID: 25629630, PMCID: PMC4393352.
Lee JH, Bhang DH, Beede A, Huang TL, Stripp BR, Bloch KD, Wagers AJ, Tseng YH, Ryeom S, Kim, CF. Lung stem cell differentiation in mice directed by endothelial cells via a BMP4-NFATc1-Thrombospondin-1 axis. Cell, 2014; 156(3):440-455. PMCID: PMC3951122.
Lau AN, Curtis SJ, Fillmore CM, Rowbotham SP, Mohseni M, Wagner DE, Beede AM, Montoro DT, Sinkevicius KW, Walton ZE, Barrios J, Weiss DJ, Camargo FD, Wong KK, Kim CF. EMBO J. 2014 Jul 1;33(13):1502. doi: 10.15252/embj.201488991. No abstract available. PMID: 24986897, PMCID: PMC3989628.
Curtis SJ, Sinkevicius KW, Li D, Lau AN, Roach RR, Zamponi R, Woolfenden AE, Kirsh DG, Wong KK, Kim CF. (2010) Primary tumor genotype is an important determinant in identification of lung cancer propagating cells. Cell Stem Cell; 7(1): 127-133.
Zacharek SJ, Fillmore CF*, Lau AN*, Gludish DW*, Chou A, Ho JWK, Zamponi R, Gazit R, Bock C,Jäger N, Smith ZD, Kim T, Saunders AH, Wong J, Lee JH, Roach RR, Rossi DJ, Meissner A, Gimelbrant AA, Park PJ, Kim CF. (2011). Lung stem cell self-renewal relies on Bmi1-dependent control of expression at imprinted loci. Cell Stem Cell 9(3): 272-81. *Equal contribution as second author
For further information on the Kim Lab, please go to http://kim.tchlab.org/