Research

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Publications

  • Kang C-M, Abbott DW, Park ST, Dascher CC, Cantley LC, Husson RN. The Mycobacterium tuberculosis serine/threonine kinases PknA and PknB: substrate identification and regulation of cell shape. Genes Dev 2005; 19: 1692-1704.
  • Park ST, Kang C-M, Husson RN. Regulation of the SigH stress response regulon by an essential protein kinase in Mycobacterium tuberculosis. Proc Natl Acad Sci USA 2008; 105:13105-13110.
  • Prisic A, Dankwa S, Schwartz D, Chou MF, Locasale J, Kang C-M, Bemis G, Church GM, Steen S, Husson RN. Extensive phosphorylation with overlapping specificity by Mycobacterium tuberculosis serine/threonine protein kinases Proc Natl Acad Sci USA 2010: 107:7521-7526. PMID: 20368441
  • Mir M, Asong J, Li X, Cardot J, Boons G-J, Husson RN. The Extracellular domain of the Mycobacterium tuberculosis Ser/Thr Kinase PknB binds specific muropeptides and is required for PknB Localization. PLoS Pathogens 2011; 7:e1002182. PMID: 21829358.
  • Sharp JD, Cruz JW, Raman S, Inouye M, Husson RN, Woychik NA. Growth and translation inhibition through sequence specific RNA binding by a Mycobacterium tuberculosis VAPC toxin. J Biol Chem 2012; 287(16): 12835–12847. doi:10.1074/jbc.M112.340109. PMID: 22354968
  • Schifano JM, Edifor R, Ouyang M, Sharp JD, Konkimalla A, Husson RN, Woychik NA. Mycobacterial toxin MazF-mt6 inhibits translation through cleavage of 23S rRNA at the ribosomal A site. Proc Natl Acad Sci USA 2013;110:8501-8506. PMID:23650345.
  • Mir M*, Prisic S*, Kang C-M, Lun S, Guo H, Murry JP, Rubin EJ, Husson RN. The mycobacterial gene cuvA/Rv1422 is required for optimal nutrient utilization and virulence. Infect Immun 2014;82:4104-4117. * co-first authors.

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