Research

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Gregory Laboratory - Lab Members

Principal Investigator

Richard Gregory Headshot

Richard I. Gregory, PhD
rgregory@enders.tch.harvard.edu

Dr. Gregory is Professor in the Departments of Biological Chemistry and Molecular Pharmacology, and Pediatrics at Harvard Medical School, and Principal Investigator in The Stem Cell Program in the Division of Hematolgy/Oncology at Boston Children’s Hospital. He is also Principal faculty member of The Harvard Stem Cell Institute, and a 2008 Pew Scholar. He received a PhD from Cambridge University, UK in 2001, studying genomic imprinting at the Babraham Institute. Dr. Gregory performed his postdoctoral work at the Fox Chase Cancer Center and the Wistar Institute, Philadelphia. His postdoctoral research focused on mechanisms of miRNA biogenesis and function, and was supported by a Jane Coffin Childs Research Fellowship. Since its establishment in 2006 research in the Gregory laboratory has focused on understanding molecular and cellular mechanisms controlling RNA biogenesis and decay and exploring the relevance of these pathways in stem cell pluripotency, mammalian development, and human disease. He is committed to exploiting the basic knowledge of RNA regulatory pathways for the discovery and development of new and effective therapies.

Post-Doctoral Fellows

Peng Du Headshot

Peng Du, PhD
peng.du@childrens.harvard.edu

Dr. Du received his PhD degree in 2012 from Peking University, Beijing, China and afterwards joined the Gregory lab. His research focuses on miRNA regulation in stem cells and cancer, as well as studying enzymatic and structurally-related noncoding RNAs’ metabolism and regulation.

Shuibin Lin Headshot

Shuibin Lin, PhD
shuibin.lin@childrens.harvard.edu

Dr. Lin received his PhD in 2012 from University of Florida, where he studied the genetic and epigenetic regulation of Notch signaling in stem cells and cancer. He is currently working on mechanisms of RNA regulation and the related roles of RNA regulation in stem cells and cancer. Dr. Lin is supported by the Damon Runyon-Sohn Pediatric Cancer Research Fellowship (2013-2017) by the Damon Runyon Cancer Research Foundation.

Robinson Triboulet Headshot

Robinson Triboulet, PhD
robinson.triboulet@childrens.harvard.edu

Dr. Triboulet earned a PhD degree from University of Montpellier I, Montpellier, France. He is primarily interested in understanding microRNA regulation and function in embryonic stem cells and cancer cell lines. Dr. Triboulet is a recipient of the Wolbach Fellowship award from the Simeon Burt Wolbach Research Fund.

Yoshinori Nishimoto Headshot

Yoshinori Nishimoto, MD, PhD
yoshinori.nishimoto@childrens.harvard.edu

Dr. Nishimoto is a Postdoctral Research Fellow in the Departments of Biological Chemistry and Molecular Pharmacology, and Pediatrics at Harvard Medical School, and the Stem Cell Program at Boston Children’s Hospital. He received his MD from Keio University School of Medicine, Japan in 2003 and practiced clinical medicine as a general internal medicine physician/neurological expert. Additionally, Dr. Nishimoto received his PhD from Keio University School of Medicine in 2008. His research has focused on Amyotrophic Lateral Sclerosis (ALS) treatment. After joining the Gregory lab in 2013, Dr. Nishimoto has been investigating pathological small non-coding RNA metabolism underlying neurological diseases. Dr. Nishimoto has been supported by several foundations including JSPS Fellowship Programs for Overseas Researchers.

Mehdi Pirouz Headshot

Mehdi Pirouz, PhD
mehdi.pirouz@childrens.harvard.edu

Dr. Pirouz received his PhD from Goettingen University, Germany (Max Planck Institute for Biophysical Chemistry) in 2013, during which he studied germ cell development and pluripotency in mouse embryonic stem cells. He also worked on the role of BAF chromatin remodeling complexes in brain development. Dr. Pirouz started his postdoctoral training in March 2014 in the Gregory lab and he is interested in the role of noncoding RNAs in stem cells, development and diseases.

Junho Choe Headshot

Junho Choe, PhD
junho.choe@childrens.harvard.edu

Dr. Choe received his PhD in 2013 then was a Postdoctoral Fellow, both at Korea University. In 2014 Dr. Choe joined the Gregory lab as a Postdoctoral Fellow and has been interested in mRNA decay and translation in mammalian cells. Dr. Choe has found intriguing translation-coupled mRNA decay machinery in mouse embryonic stem cells and is also interested in mRNA modifications involved in translation.

Lab Manager

Carmen Rios Headshot

Carmen Rios, MS, MBA
carmen.rios@childrens.harvard.edu

Carmen earned her MBA degree from the University of Houston in 2010 and her Master’s degree in Bioengineering from the University of Pittsburgh in 2012. Though Carmen's background/training and past research was in Biomedical Engineering, Carmen is eager to broaden her toolkit of knowledge by learning as much as she can about molecular biology, namely RNA biogenesis, function and regulation.

Tech Specialist

Marzia Munafo Headshot

Marzia Munafo, MS
marzia.munafo@childrens.harvard.edu

Marzia earned her Master's Degree in Genetics and Molecular Biology at "Sapienza" University of Rome in 2015. After being a summer student in the Gregory lab, she recently re-joined the lab as a Research Assistant. Marzia's work aims to define the molecular and cellular role of a newly identified 3’-5’ exoribonuclease, DIS3L2, and its involvement in RNA processing and decay in stem cells.

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