Research

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Adrianne Kolpak

Adrianne Kolpak, Ph.D., Post-doctoral Research Fellow

Adrianne earned her Ph.D. in cell biology from the University of Massachusetts Medical School in 2010.  Her thesis research focused on the concentration-dependent effect of Sonic hedgehog on axon guidance and membrane trafficking within axonal growth cones.  Adrianne joined the Engle lab as a postdoctoral fellow in August 2010.  She is currently investigating the effect of pathological mutations in beta-III tubulin on axon growth and guidance in order to better understand the etiology of the eye movement disorder, CFEOM3.

Representative publications from graduate school:

  1. Peter, C.J., Evans, M., Thayanithy, V., Taniguchi-Ishigaki, N., Bach, I., Kolpak, A., Bassell, G., Rossoll, W., Lorson, C.L., Bao, Z.Z., Androphy, E.J.  2011.  The COPI vesicle complex binds and moves with Survival Motor Neuron within axons.  Hum Mol Genet 20, 1701-11.
  2. Jiang, J., Kolpak, A.L., and Bao, Z.Z.  2009.  Distinct roles of myosin IIA and IIB isoforms in macropinosome formation in Neuro-2a cells.  Cell Motil Cytoskeleton, 1-12. 
  3. Kolpak, A.L., Jiang, J., Guo, D., Standley, C., Bellve, K., Fogarty, K., and Bao, Z.Z.  2009.  Negative guidance factor-induced macropinocytosis in the growth cone plays a critical role in repulsive axon turning.  J. Neurosci 29, 10488-98.
  4. Kolpak, A., Zhang, J., and Bao, Z.Z.  2005.  Sonic hedgehog has a dual effect on the growth of retinal axons depending on its concentration.  J. Neurosci 25, 3432-3441.

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