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Cowan Laboratory

Douglas B. Cowan, Ph.D.

Title Associate Professor

Boston Children's Hospital
Harvard Medical School

Department Anesthesiology, Perioperative and Pain Medicine
Address Boston Children's Hospital
Enders Room 312.1
300 Longwood Avenue
Boston MA  02115
Phone (617) 919-2655

Lab Overview

Our laboratory is developing cell-based therapies to treat heart disease in humans. Currently, we are focused on the following pre-clinical research projects:

  1. Engineering autologous tissue to function as a permanent atrioventricular electrical conduit as an alternative to pacemaker implantation in children with complete heart block

  2. Designing methods to expand and direct the differentiation of stem cell populations to determine their regenerative potential for the treatment of cardiac diseases

  3. Assessing non-invasive, imaging modalities to serially track the retention, distribution, and function of transplanted cells in experimental therapeutic trials

  4. Transplanting mitochondria to the heart to decrease the extent of damage following a heart attack and enhance functional recovery


 Molecular Biology

Cell Biology 

 Confocal Microscopy

 Cardiac Physiology


 Fluorescence Microscopy


Stem Cell Biology 

 Electron Microscopy

 Cell Culture


 Molecular Imaging

 Optical Surface Mapping

Cardiovascular Surgery

 Tissue Engineering 

Related Links

Surgical Research Council

Research Brochure

Google Scholar

Harvard Catalyst

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