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Bischoff Laboratory Recent Publications

2016

Bischoff J, Casanovas G, Wylie-Sears J, Kim D-H, Bartko PE, Guerrero JL, Dal-Bianco JP, Beaudoin J,  Garcia ML, Sullivan SM, Seybolt MM, Morris BA, Keegan J, Irvin WS, Aikawa E, Levine RA, CD45 expression in mitral valve endothelial cells aftermyocardial infarction. Circ Res. 2016 Oct 6. pii: CIRCRESAHA.116.309598. PMID: 27750208

Huang L, Couto JA, Pinto A, Alexandrescu S, Madsen JR, Greene AK, Sahin M, Bischoff J, Somatic GNAQ mutation is enriched in brain endothelial cells in Sturge-Weber Syndrome. Pediatric Neurology 2016, in press

Ayturk UM, Couto JA, Hann S, Mulliken JB, Williams K, Fishman SJ, Kozakewich HPW, Bischoff J, Greene AK, Warman ML., Somatic Activating Mutations in GNAQ and GNA11 are Associated with Congenital Hemangioma. Am J Hum Genet. 2016; 98(4):789-95.

Dal-Bianco JP, Aikawa E, Bischoff J, Guerrero JL, Hjortnaes J, Beaudoin J, Szymanski C, Bartko PE, Seybolt MM, Handschumacher MD, Sullivan S, Garcia ML, Mauskapf A, Titus JS, Wylie-Sears J, Irvin WS, Chaput M, Messas E, Hagège AA, Carpentier A, Levine RA; Leducq Transatlantic Mitral Network. Myocardial Infarction Alters Adaptation of the Tethered Mitral Valve. J Am Coll Cardiol. 2016 Jan 26;67(3):275-87.

Ye X, Abou-Rayyah Y, Bischoff J, Ritchie A, Sebire NJ, Watts P, Churchill AJ, Bates DO. Altered ratios of pro- and anti-angiogenic VEGF-A variants and pericyte expression of DLL4 disrupt the vascular maturation in infantile haemangioma. J. Pathol. 2016 Mar 9. doi: 10.1002/path.4715. [Epub ahead of print] 

Couto JA*, Huang L* (co-first authors), Vivero MP, Kamitaki N, Maclellan RA, Mulliken JB, Bischoff J, Warman ML, Greene AK. Endothelial cells from capillary malformations are enriched for somatic GNAQ mutations. Plast Reconstr Surg. 2016 Jan; 137(1):77e-82e. 


2015

Boscolo E, Limaye N, Huang L, Kang KT, Soblet J, Uebelhoer M, Mendola A, Natynki M, Seront E, Dupont S, Hammer J, Legrand C, Brugnara C, Eklund L, Vikkula M, Bischoff J, Boon LM. Rapamycin improves TIE2-mutated venous malformation in murine model and human subjects. J Clin Invest. 2015; 125 (9): 3491-504. 

Smadja DM, Levy M, Huang L, Rossi E, Blandinieres A, Israël-Biet D, Gaussem P, Bischoff J. Treprostinil indirectly regulates endothelial colony forming cell angiogenic properties by increasing VEGF-A produced by mesenchymal stem cells. Thromb Haemost. 2015; 114(4): 735-47. 

Shapero K, Wylie-Sears J, Levine RA, Mayer JE Jr, Bischoff J. Reciprocal interactions between mitral valve endothelial and interstitial cells reduce endothelial-to-mesenchymal transition and myofibroblastic activation. J Mol Cell Cardiol. 2015 Mar;80:175-85.

Boscolo E, Coma S, Luks VL, Greene AK, Klagsbrun M, Warman ML, Bischoff J. AKT hyper-phosphorylation associated with PI3K mutations in lymphatic endothelial cells from a patient with lymphatic malformation. Angiogenesis. 2015 Apr;18(2):151-62.


Huang L, Nakayama H, Klagsbrun M, Mulliken JB, Bischoff J. Glucose transporter 1-positive endothelial cells in infantile hemangioma exhibit features of facultative stem cells. Stem Cells. 2015 Jan;33(1):133-45.

Hjortnaes J, Shapero K, Goettsch C, Hutcheson JD, Keegan J, Kluin J, Mayer JE, Bischoff J, Aikawa E. Valvular interstitial cells suppress calcification of valvular endothelial cells. Atherosclerosis. 2015 Sep;242(1):251-60.

Nakayama H, Huang L, Kelly RP, Oudenaarden CR, Dagher A, Hofmann NA, Moses MA, Bischoff J, Klagsbrun M. Infantile hemangioma-derived stem cells and endothelial cells are inhibited by class 3 semaphorins. Biochem Biophys Res Commun. 2015 Aug 14;464(1):126-32.

Yu CW, Liang X, Lipsky S, Karaaslan C, Kozakewich H, Hotamisligil GS, Bischoff J, Cataltepe S. Dual role of fatty acid-binding protein 5 on endothelial cell fate: a potential link between lipid metabolism and angiogenic responses. Angiogenesis. 2016 Jan;19(1):95-106. Epub 2015 Dec 1. 

Rossi E, Smadja DM, Boscolo E, Langa C, Arevalo MA, Pericacho M, Gamella-Pozuelo L, Kauskot A, Botella LM, Gaussem P, Bischoff J, Lopez-Novoa JM, Bernabeu C. Endoglin regulates mural cell adhesion in the circulatory system. Cell Mol Life Sci. 2015 Dec 8. [Epub ahead of print] 

Levine RA, Hagége AA, Judge DP, Padala M, Dal-Bianco JP, Aikawa E, Beaudoin J, Bischoff J, Bouatia-Naji N, Bruneval P, Butcher JT, Carpentier A, Chaput M, Chester AH, Clusel C, Delling FN, Dietz HC, Dina C, Durst R, Fernandez-Friera L, Handschumacher MD, Jensen MO, Jeunemaitre XP, Marec HL, Tourneau TL, Markwald RR, Mérot J, Messas E, Milan DP, Neri T, Norris RA, Peal D, Perrocheau M, Probst V, Pucéat M, Rosenthal N, Solis J, Schott JJ, Schwammenthal E, Slaugenhaupt SA, Song JK, Yacoub MH; Leducq Mitral Transatlantic Network. Mitral valve disease-morphology and mechanisms. Nat Rev Cardiol. 2015 Dec;12(12):689-710. Epub 2015 Oct 20.

Hofmann NA, Yang J, Trauger SA, Nakayama H, Huang L, Strunk D, Moses MA, Klagsbrun M, Bischoff J, Graier WF. The GPR 55 agonist, L-α-lysophosphatidylinositol, mediates ovarian carcinoma cell-induced angiogenesis. Br J Pharmacol. 2015 Aug;172(16):4107-18.

Jia D, Huang L, Bischoff J, Moses MA. The endogenous zinc finger transcription factor, ZNF24, modulates the angiogenic potential of human microvascular endothelial cells. FASEB J. 2015 Apr;29(4):1371-82.

2014

Smadja D, Guerin CL, Boscolo B, Bieche B, Mulliken JB, Bischoff Jα6-Integrin plays a major role in the vasculogenic potential of hemangioma stem cells. Stem Cells, 2014; 32(3):684-93.

Wylie-Sears J, Levine RA, Bischoff JLosartan inhibits endothelial-to-mesenchymal transformation in mitral valve endothelial cells by blocking transforming growth factor-β-induced phosphorylation of ERK. Biochem Biophys Res Commun. 2014;446(4):870-5

Lee D, Boscolo E, Durham JT, Mulliken JB, Herman IM, Bischoff J. Propranolol targets contractility of infantile hemangioma-derived pericytes. Br J Dermatol. 2014 Apr 10. doi: 10.1111/bjd.13048.

Sawada N, Jiang A, Takizawa F, Safdar A, Manika A, Tesmenitsky Y, Kang KT, Bischoff J, Kalwa H, Sartoretto JL, Kamei Y, Benjamin LE, Watada H, Ogawa Y, Higashikuni Y, Kessinger CW, Jaffer FA, Michel T, Sata M, Croce K, Tanaka R, Arany Z. Endothelial PGC-1α mediates vascular dysfunction in diabetes.  Cell Metab. 2014 Feb 4;19(2):246-58.

Gelfand MV, Hagan N, Tata A, Oh WJ, Lacoste B, Kang KT, Kopycinska J, Bischoff J, Wang JH, Gu C. Neuropilin-1 functions as a VEGFR2 co-receptor to guide developmental angiogenesis independent of ligand binding. Elife. 2014 Sep 22;3:e03720.

Smadja DM, Dorfmüller P, Guerin CL, Bieche I, Badoual C, Boscolo E, Kambouchner M, Cazes A, Mercier O, Humbert M, Gaussem P, Bischoff J, Israël-Biet D. Cooperation between human fibrocytes and endothelial colony-forming cells increases angiogenesis via the CXCR4 pathway. Thromb Haemost. 2014 Nov;112(5):1002-13. 

2013

Boscolo E, Mulliken JB, Bischoff J. Pericytes from infantile hemangioma display proangiogenic properties and dysregulated angiopoietin-1. Arterioscler Thromb Vasc Biol. 2013; 33(3):501-9. Editors Pick

Greenberger S, Bischoff J. Pathogenesis of Infantile Hemangioma. Br J Dermatol. Br J Dermatol. 2013 Jul; 169(1):12-9.

Kang KT, Coggins M, Xiao C, Rosenzweig A, Bischoff J. Human vasculogenic cells form functional blood vessels and mitigate adverse remodeling after ischemia reperfusion injury in rats. Angiogenesis. 2013 16(4):773-84.

Allen P, Kang KT, Bischoff J. Rapid onset of perfused blood vessels after implantation of ECFCs and MPCs in collagen, PuraMatrix and fibrin provisional matrices. 2013, J Tissue Eng Regen Med, J Tissue Eng Regen Med. 2013 Aug 16. [Epub ahead of print]

2012

Smadja D, Mulliken JB, Bischoff J. E-selectin mediates stem cell adhesion and formation of blood vessels in a murine model of infantile hemangioma. Am J Path. 2012 181(6):2239-47.

2011

Allen P, Melero-Martin JM, Bischoff J. Type I collagen, fibrin and Puramatrix matrices provide permissive environments for human endothelial and mesenchymal progenitor cells to form eovascular networks. J Tissue Eng Regen Med. 2011; 5(4):e74-86.

Wylie-Sears J, Aikawa E, Levine RA, Yang J-H, Bischoff J. Mitral valve endothelial cells with osteogenic differentiation potential.  Arterioscler Thromb Vasc Biol. 2011; 31(3):598-607. Epub 2010 Dec 16.

Boscolo E, Stewart CL, Greenberger S, Wu JK, Durham JT, Herman IM, Mulliken JB,  Kitajewski J, Bischoff J. JAGGED1 signaling regulates hemangioma stem cell-to-pericyte/vascular smooth muscle cell differentiation. Arterioscler Thromb Vasc Biol. 2011; 31(10):2181-92.

Greenberger S, Yuan S, Walsh LA, Boscolo E, Kang K-T, Matthews B, Mulliken JB, Bischoff J. Rapamycin Suppresses Self-Renewal and Vasculogenic Potential of Stem Cells Isolated from  Infantile Hemangioma. J Invest Dermatol. 2011; 131(12):2467-76. Selected for Editorial Commentary

Boscolo E, Mulliken JB, Bischoff J. VEGFR-1 mediates endothelial differentiation and formation of blood vessels in a murine model of infantile hemangioma.  Am J Pathol. 2011; 179(5):2266-77.

Kang KT, Allen P, Bischoff J. Bioengineered human vascular networks transplanted into secondary mice reconnect with the host vasculature and re-establish perfusion.  Blood.  2011; 118(25): 6718-21.

Bischoff  J. and Aikawa E. Progenitor Cells Confer Plasticity to Cardiac Valve Endothelium. J Cardiovasc Transl Res. 2011 Dec; 4(6):710-9

2010

Greenberger S, Boscolo E, Adini I, Mulliken JB, Bischoff J. Corticosteroid suppression of VEGF-A in infantile hemangioma-derived stem cells.  N Engl J Med. 2010 362 (11): 1005-1013. 

Melero-Martin JM, De Obaldia ME, Allen P, Dudley AC, Klagsbrun M, Bischoff JHost myeloid cells are necessary for creating bio-engineered human vascular networks in vivo. Tissue Eng Part A. 2010; 16(8):2457-66.

Greenberger S, Adini I, Boscolo E, Mulliken JB, Bischoff J. Targeting NF-κB in infantile hemangioma-derived stem cells reduces VEGF-A expression. Angiogenesis. 2010; 13(4): 327-335.

2009

Dal-Bianco JP, Aikawa E*, Bischoff J*, Guerrero JL, Handschumacher MD, Sullivan S, Johnson B, Titus JS, Iwamoto Y, Wylie-Sears J, Levine RA,  Carpentier A. Active adaptation of the tethered mitral valve: Insights into a compensatory mechanism for functional mitral regurgitation. Circulation. 2009; 120:334-42   *indicates co-second authors.  Selected for Editorial Commentary

2008

Khan ZA, Boscolo E, Picard A, Psutka S, Melero-Martin JM, Bartch TC, Mulliken JB, Bischoff JMultipotential stem cells recapitulate human infantile hemangioma in immunodeficient mice. J Clin Invest. 2008; 118(7): 2592-9. Highlighted in the July issue of J Clin Invest.

Melero-Martin JM, De Obaldia ME, Kang SY, Khan ZA, Yuan L, Oettgen P, Bischoff J. Engineering robust and functional vascular networks in vivo with human adult and cord blood-derived progenitor cells. Circ Res. 2008; 103(2): 194-202. Selected to for an Editorial Commentary and 2009 Best Manuscript Award, Circulation Research

Yang JH, Wylie-Sears J, Bischoff J. Opposing actions of Notch1 and VEGF in post-natal cardiac valve endothelial cells.  Biochem Biophys Res Commun. 2008; 374(3): 512-6.

Picard A, Boscolo E, Khan ZA, Bartch TC, Mulliken JB, Vazquez MP, Bischoff J. IFG-2 and FLT-1/VEGF-R1 mRNA levels reveal distinctions and similarities between congenital and common infantile hemangioma. Pediatric Res. 2008; 63(3): 263-7.

Selected Publications 2001-2007

Boye E, Yu Y, Paranya G, Mulliken JB, Olsen BR, Bischoff J. Clonality and altered behavior of endothelial cells from hemangioma.  J Clin Invest. 2001; 107(6): 745-52.

Paranya G, Vineberg S, Dvorin, E. Kaushal S, Roth SJ, Rabkin E, Schoen FJ, Bischoff J. Aortic valve endothelial cells undergo transforming growth factor-β-mediated and non-transforming growth factor-β-mediated transdifferentiation in vitro. Am J Pathol. 2001; 159(4):1335-43.

Kaushal S, Amiel GE, Guleserian KJ, Shapira OM, Perry T, Sutherland FW, Rabkin E, Moran AM, Schoen FJ, Atala A, Soker S, Bischoff J, Mayer JE Jr. Functional small-diameter neovessels created using endothelial progenitor cells expanded ex vivo. Nat Med. 2001; 7(9): 1035-40.

Johnson EN, Lee YM, Sander TL, Rabkin E, Schoen FJ, Kaushal S, Bischoff J. NFATc1 mediates VEGF-induced proliferation in human pulmonary valve endothelial cells.  J Biol Chem. 2003; 278(3): 1686-92.

Yu Y, Flint AF, Mulliken JB, Wu JK, Bischoff J. Endothelial progenitor cells in infantile hemangioma. Blood. 2004; 103(4): 1373-5.

Yu Y, Moulton KS, Khan MK, Vineberg S, Boye E, Davis VM, O’Donnell PE, Bischoff J, Milstone DS. E-Selectin is required for the anti-angiogenic activity of endostatin. Proc Natl Acad Sci USA. 2004; 101(21): 8005-10.

Wu X, Rabkin-Aikawa E, Guleserian KJ, Perry TE, Masuda Y, Sutherland FW, Schoen FJ, Mayer JE Jr., Bischoff J. Tissue-engineered microvessels on three-dimensional biodegradable scaffolds using human endothelial cell progenitor cells. Am J Phys Heart Circ Physiol. 2004; 287(2):H480-7.

Lee YM, Cope JJ, Ackermann GE, Goishi K, Armstrong EJ, Paw BH, Bischoff J. Vascular endothelial growth factor signaling is required for cardiac valve formation in zebrafish. Developmental Dynamics. 2006; 235(1): 29-37.

Paruchuri S, Yang J-H, Aikawa E, Melero-Martin JM, Khan ZA, Loukogeorgakis S, Schoen FJ, Bischoff J. Human pulmonary valve progenitor cells exhibit endothelial/mesenchymal plasticity in response to vascular endothelial growth factor-A and transforming growth factor-β2. Circ Res. 2006; 99(8): 861-9.

Melero-Martin JM, Khan ZA, Picard A, Wu X, Paruchuri S, Bischoff J. In vivo vasculogenic potential of human blood-derived endothelial progenitor cells. Blood. 2007; 109(11): 4761-8.        

Wu X, Lensch MW, Wylie-Sears J, Daley GQ, Bischoff J. Hemogenic endothelial progenitor cells isolated from human umbilical cord blood. Stem Cells. 2007; 25(11): 2770-6. 

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