The effect of environment on pre and post-surgical general well-being and pain-sensitivity tests
This animal model is being conducted in conjunction with the F.M. Kirby Neurobiology Center at BCH and complements the ongoing human study on persistent post surgical pain (see Biopsychosocial Predictors of Persistent Postsurgical Pain for more information). The aims of this study is to model in young and adult mice whether an altered pre-surgical environment (chronic mild stress, enriched, or standard) can reliably predict pre- and post-surgical general well-being and pain sensitivity tests. We are currently exploring whether gene-environmental interaction can reliably predict pre- and post-surgical general well-being and pain sensitivity tests in young and adult mice.
Current status: N/A (animal model)
Funding: The Sara Page Mayo Endowment for Pediatric Pain Research and Treatment, and the Department of Anesthesiology, Perioperative and Pain Medicine at Boston Children's Hospital