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Berde Lab | News

Welcome new students!

June 2017

Dafni Frohman has joined the lab for a summer placement as a BS student (Class of 2019).  Dafni is part of the Biological Sciences program at Tufts University. Dafni is working on a series of chronic pain projects using statistical approaches. 

Welcome new lab members!

February 2017

Uday Agrawal has joined the lab as a MD student (Class of 2020).  Uday is part of the Health-Sciences Technology program at Harvard Medical School. He will be characterizing burst suppression during deep anesthesia using EEG-NIRS and advanced signal processing techniques.

Talks and poster presentations at IARS

May 2017

Laura Cornelissen and Norah Liang (MD student, UCSF) presented their work at the International Anesthesia Research Society Annual Scientific Meeting in Washington, DC, May 5th to May 9th.

  • Laura gave a talk at the SmartTots workshop session on “Neuroscience of Brain Development: Opportunities and Alternative Perspectives for Pediatric Anesthesia Research”.  Laura discussed the role of brain monitoring and EEG spectral analysis in anesthetic monitoring of young children.  She demonstrated the usefulness of EEG when detecting anesthetic depth and the usefulness of EEG in detecting periods of brain stress.  Other panelists were colleagues: Dr Patrick Purdon (MGH), Dr Takao Hensch (BCH) and Dr Jeff Sall (UCSF).
  • Liang Poster Presenatin

The SmartTots session is available online for on-demand viewing (http://smarttots.org/resources/livestream/).  Dr Cornelissen’s talk starts at 1:02:37.

  • Norah Liang gave a poster presentation on “Clinical signs and electroencephalographic patterns of emergence from sevoflurane anesthesia in children”.  Norah was recently awarded the Dean’s Prize for her research.

New paper published in Regional Anesthesia & Pain Medicine

May 2017

A new paper, “Continuous regional anesthesia and inpatient rehabilitation for pediatric complex regional pain syndrome” has been published in Regional Anesthesia & Pain Medicine

https://www.ncbi.nlm.nih.gov/pubmed/28492436

Congratulations Genevieve! 

May 2017

Congratulations to Genevieve for completing her MS degree. Genevieve completed her MS thesis on a retrospective chart review to investigate the effectiveness of lumbar medial branch block on chronic lower back pain in children and young adults. We’re glad Genevieve has decided to continue to working in our lab before heading off to medical school! 

New paper published in Journal of Neurosurgery: Spine

May 2017

A new paper, led by the Departments of Neurosurgery and Radiology, “Image-guided intrathecal baclofen pump catheter implantation: a technical note and case series” has been published in the Journal of Neurosurgery: Spine

https://www.ncbi.nlm.nih.gov/pubmed/28156208

Welcome new lab members!

February 2017

Uday Agrawal has joined the lab as a MD student (Class of 2020).  Uday is part of the Health-Sciences Technology program at Harvard Medical School. He will be characterizing burst suppression during deep anesthesia using EEG-NIRS and advanced signal processing techniques.  

New paper published in Pediatric Anesthesia

February 2017

A new paper in collaboration with Department of Neurology colleagues, Ann Bergin and Janet Soul, “Electroencephalographic discontinuity during sevoflurane anesthesia in infants and children” has been published in Pediatric Anesthesia.  The paper is accompanied with a commentary by Andrew Weatherall and Justin Skowno from the University of Sydney, Australia.

https://www.ncbi.nlm.nih.gov/pubmed/28177176

Andrea selected for student talk at ICHAMS

February 2017

Andrea Tou (MD student, Royal College of Surgeons in Ireland) has been selected to give an oral presentation at the ICHAMS conference in Dublin, February 17th.  Andrea will be talking about her summer project on clinical signs of emergence from general anesthesia in children.  

http://ichams.org/

Welcome new lab members!

January 2017

Mohammad Haji has joined the lab as an MD student on a 6-month research placement.  Mohammad is a student at the Weill Cornell Medicine in Qatar. 

Norah wins Short-Term Dean’s Prize in Research and Scholarship

December 2016

Norah Liang (MD student, UCSF) was selected to receive the “Short-term Dean’s Prize in Research and Scholarship” for the 2016-2017 year.  Norah worked with Laura Cornelissen on the dose-dependent effects of general anesthesia on clinical signs and brain activity in children. Well done Norah!

New paper published on Neosaxitoxin

November 2016

A new paper in collaboration with Department of Laboratory Medicine colleagues, Mark Kellogg, Roy Peake and others, “Measurement of neosaxitoxin in human plasma using liquid-chromatography tandem mass spectrometry: proof of concept for a pharmacokinetic application” has been published in the Journal of Chromatography B: Biomedical Sciences and Applications.

http://www.sciencedirect.com/science/journal/03784347


New commentary published in Nature

August 2016

A commentary written by Laura Cornelissen and Chuck Berde, “Biomedical science: protection for anesthetized mice”, has been published in Nature.

https://www.ncbi.nlm.nih.gov/pubmed/27488795


New commentary published in Pediatric Blood & Cancer

July 2016

A commentary written by Carolina Donado, Chuck Berde and Anjali Koka, “Lidocaine infusions and other options for opioid-resistant pain due to pediatric advanced cancer”, has been published in Pediatric Blood & Cancer.

https://www.ncbi.nlm.nih.gov/pubmed/27082947

Welcome new lab members!

June 2016

Genevieve Spagnuolo has joined the lab as a MS student. Genevieve is part of the MS in biomedical sciences program at Tufts University.  We also welcome new summer research students, Norah Liang (UCSF), Andrea Tou (Royal College of Surgeons in Ireland) and Ian Mills (University of Connecticut).

New publication in Journal of Cerebral Blood Flow & Metabolism

May 2016

A new paper presented with our Optics Division colleagues, Ivy Lin, Jason Sutin, Ellen Grant and Mari Francescini, “Intra-operative Measures of Cerebral Perfusion and Oxygen Consumption in Anaesthetized Infants Using Diffuse Correlation spectroscopy and Near-Infra Red Spectroscopy”, is published in the Journal of Cerebral Blood Flow & Metabolism. This work was also presented at the BRAIN meeting in Vancouver, Canada, June 27th-30th 2015. 

http://iscbfm.org/Meetings/Brain2015_Abstracts.aspx

Congratulations! Dr. Bilge

April 2016

Congratulations! Dr. Bilge, anesthesiologist and co-investigator, presented his work investigating the clinical and neurophysiological patterns of "waking up" from general anesthesia in infants at the Society for Pediatric Anesthesia meeting in Colorado Springs, CO.

New commentary published in Pediatric Anesthesia

February 2016

A commentary written by Chuck Berde with George Chalkiadis from the Royal Children’s Hospital Melbourne, Australia, on “Bundled analgesia interventions for day-stay surgery” has been published in Pediatric Anesthesia. 

https://www.ncbi.nlm.nih.gov/pubmed/?term=Bundled+analgesia+interventions+for+day-stay+surgery.

New paper published in Lancet

January 2016

A new paper, as a member of the GAS consortium and the North American site, on “Neurodevelopmental outcome at 2 years of age after general anesthesia and awake-regional anesthesia in infancy (GAS): an international multicenter, randomized controlled trial” has been published in the Lancet. 

https://www.ncbi.nlm.nih.gov/pubmed/26507180

New paper published in Frontiers in Human Neuroscience

January 2016

A new paper in collaboration with Laura Simons, David Borsook and Lino Becerra in the Center for Pain and the Brain, “Fear and reward circuit alterations in pediatric CRPS” has been published in Frontiers in Human Neuroscience

https://www.ncbi.nlm.nih.gov/pubmed/?term=Fear+and+Reward+Circuit+Alterations+in+Pediatric+CRPS


New paper published in Regional Anesthesia & Pain Medicine

January 2016

A new paper in collaboration with colleagues in the Departments of Orthopedic Surgery, and Neurosurgery, “Epidural steroid injections for radiculopathy and/or back pain in children and adolescents: a retrospective cohort study with a prospective follow-up”, has been published in Regional Anesthesia and Pain Medicine

https://www.ncbi.nlm.nih.gov/pubmed/26655219

November 2015

Innovative research, discoveries and big ideas were all part of the BCH Innovation Summit! Chuck Berde presented his work and future vision for "Transforming Pain Relief and Recovery After Surgery." 

Check out Dr. Berde's presentation here: http://takingontomorrow.org/video/ 

Well done Laura Cornelissen! Laura gave a talk to the American Society of Anesthesiologists in San Diego, CA. She was one of 8 Young Investigators selected to talk about their clinical research.

October 2015

Laura Cornelissen presented her research at the Society for Neuroscience annual meeting, Chicago, IL. She was among 30,000 neuroscientists from more than 80 countries who attended.

September 2015

In the news! The Harvard Gazette reports on work we have published with our collaborators from MGH and MIT showing brain effects of anesthesia differ in young children!  Read more here: Age and Anesthesia | HMS.

August 2015

New publications!  Check out our latest double publication on Neosaxitoxin as a novel drug for long lasting anesthesia in the latest issue of Anesthesiology.

July 2015

Welcome! Johanna Lee, an HST student has joined the Berde Lab for a one year research placement in collaboration with Prfessor Brown's Neuroscience Statistics Research lab at MIT.

New publications! Check out our latest publication on the effect of cold temperature on pain sensation in the Journal of Investigative Dermatology.

This is a study led by our collaborators at MGH that shows how an hour of controlled cooling of the skin can lead to long-lasting decreases in sensitivity to temperature and touch. More clinical studies are needed to investigate the potential effect of this technique as therapy for prolonged relief of cutaneous pain.  

June 2015

Congratulations! Charles Berde was awarded the Distinguished Career Award in Pediatric Pain by the Special Interest Group on Pain in Childhood.This prestigious award is given to an individual who has dedicated their outstanding career to alleviating children's pain. The recipient is chosen based on scientific contributions, teaching and advocacy.

Charles Berde was an invited plenary speaker at the 10th International Symposium on Pediatric Pain in Seattle, WA.

Laura Cornelissen gave a talk titled: "Anesthesia, Alpha Oscillations and the Developing Brain" at the 10th International Symposium on Pediatric Pain in Seattle, WA.


May 2015

Well done! 

Laura Cornelissean was awarded the 2015 International Anesthesia Research Society Mentored Research Award! Congratulations to Kimberly Lobo on her promotion to Biostatistician.

January 2015

Carolina Donado and Joe Kossowsky published their work on "Immediate Rescue Designs in Pediatric Analgesic Trials" in Anesthesiology. 

This study is a systematic review and meta-analysis of the performance of rescue analgesic designs in pediatric trials of commonly used classes of analgesics. They show that opioid sparing is a feasible pragmatic end-point for pediatric pain analgesic trials.

November 2014

In the news!  Boston Globe named Dr. Berde's work on Neosaxitoxin as one of the "10 biggest breakthroughs in healthcare coming soon". Read more here.

October 2014

Carolina Donado gave a talk on "Long-acting local anesthesia with Neosaxitoxin: a randomized, controlled, double-blind FDA phase 1 trial" at the American Society of Anesthesiologists Scientific Meeting in New Orleans, LO.  This work was awarded the "Best Clinical Abstract of the Meeting".

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