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Jay Thiagarajah, MD, PhD

College: Kings College London

Medical School: St. George’s, University of London

Graduate School: Kings College London, Phd in Physiology

Residency: Massachusetts General Hospital

Research Mentor: Wayne Lencer, MD

Research Project: The role of Aquaporins in colonic crypt regeneration.  Aquaporins are water and small solute channels that are expressed in many tissues including the intestine.  Previous studies have shown that aquaporins seem to be involved in repair of the colonic epithelium in response to injury, but the mechanisms involved are unknown.  The aim of the project is to elucidate these mechanisms and test whether modulation of aquaporin expression or function may be beneficial in tissue repair after inflammation.


  1. Thiagarajah, J.R., Yildiz H., Carlso. T., Thomas A.R., Steiger C., Pieretti A., Zukerberg L.R., Carrier R.L., Golstein A.M. (2014). Altered goblet cell differentiation and surface mucus properties in hirschsprung disease. PLoS One. ((6):e99944.
  2. Ko E.A., Jin B.J., Namkung W., Ma T., Thiagarajah J.R., Verkman A.S. (2013) Chloride channel inhibition by a red wine extract and a synthetic small molecule prevents rotaviral secretory diarrhea in neonatal mice. Gut. Sep 19.
  3. Jin B.J., Thiagarajah J.R., Verkman A.S. (2013) Convective washout reduces the antidiarrheal efficacy of enterocyte surface-targeted antisecretory drugs. J Gen Physiol. Feb;141(2):261-72.
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