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Amy Tsou MD, PhD


College: Rice University

Graduate School: PhD in Cell and Molecular Biology, University of Pennsylvania

Medical School: University of Pennsylvania Raymond and Ruth Perelman School of Medicine

Residency: Boston Children's Hospital Combined Residency

Research Mentor: Scott Snapper, MD, PhD

Awards: North American Society for Pediatric Gastroenterology, Hepatology and Nutrition Teaching and Tomorrow Grant 2012; T32 Bacteriology Training Grant 2007-2008, Dr. and Mrs. David M. Mumford Health Professions Leadership Award 2004.


  1. Tsou, A.M., and J. Zhu. 2012. Quorum sensing regulation of pathogenesis and environmental survival in foodborne Vibrios. In Stress Responses in Foodborne Microorganisms.
  2. Tsou, A. M., Z. Liu, T. Cai, and J. Zhu. 2011. The VarS/VarA two-componentsystem modulates the activity of the Vibrio cholerae quorum-sensing transcriptional regulator HapR. Microbiology 157:1620-1628.
  3. Liu, Z., M. Yang, G. L. Peterfreund, A. M. Tsou, N. Selamoglu, F. Daldal, Z. Zhong, B. Kan, and J. Zhu. 2011. Vibrio cholerae anaerobic induction of virulence gene expression is controlled by thiol-based switches of virulence regulator AphB. Proc Natl Acad Sci U S A 108:810-815.
  4. Tsou, A. M., and J. Zhu. 2010. Quorum sensing negatively regulates hemolysin transcriptionally and posttranslationally in Vibrio cholerae. Infect Immun 78:461- 467.
  5. Tsou, A. M., T. Cai, Z. Liu, J. Zhu, and R. V. Kulkarni. 2009. Regulatory targets of quorum sensing in Vibrio cholerae: evidence for two distinct HapR-binding motifs. Nucleic Acids Res 37:2747-2756.
  6. Chavez, A., A. M. Tsou, and F. B. Johnson. 2009. Telomeres do the (un)twist: helicase actions at chromosome termini. Biochim Biophys Acta 1792:329-340.
  7. Cai, T., W. Cai, J. Zhang, H. Zheng, A. M. Tsou, L. Xiao, Z. Zhong, and J. Zhu. 2009. Host legume-exuded antimetabolites optimize the symbiotic rhizosphere. Mol Microbiol 73:507-517.
  8. Tsou, A. M., E. M. Frey, A. Hsiao, Z. Liu, and J. Zhu. 2008. Coordinated regulation of virulence by quorum sensing and motility pathways during the initial stages of Vibrio cholerae infection. Commun Integr Biol 1:42-44.
  9. Liu, Z., T. Miyashiro, A. Tsou, A. Hsiao, M. Goulian, and J. Zhu. 2008. Mucosal penetration primes Vibrio cholerae for host colonization by repressing quorum sensing. Proc Natl Acad Sci U S A 105:9769-9774.
  10. Wang, Y., M. R. Spitz, A. M. Tsou, K. Zhang, N. Makan, and X. Wu. 2002. Sulfotransferase (SULT) 1A1 polymorphism as a predisposition factor for lung cancer: a case-control analysis. Lung Cancer 35:137-142.

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