Research

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Centers of Excellence

The Center for Inflammatory Bowel Disease

The Center for Inflammatory Bowel Disease at Boston Children's Hospital, directed by Dr. Richard Grand, is an integrated, multidisciplinary research, teaching, and care program that aims to address the unique features of childhood-onset inflammatory bowel disease (IBD). The Center is comprised of seven core programs: basic research in epithelial cell and molecular biology and the molecular biology of the immune response, clinical research, pharmacology, nutrition, cancer biology and surveillance, outcomes research, and health care policy. The goals of Center activities are to stimulate interactions between investigative units at Children's Hospital currently working in areas relevant to IBD, and to initiate new projects in laboratories not yet studying IBD. In addition to data sessions and conferences already ongoing in the individual laboratories, a twice monthly conference on Wednesday afternoons focuses on discussions of projects, protocols, and plans for the Center, and it provides an opportunity for fellows and staff to participate actively in IBD research. This center is in part supported by core facilities and pilot feasibility funding by the Harvard Digestive Diseases Center at Children's Hospital (PI: Dr. Wayne I. Lencer).


The Celiac Disease Program and Support Group

The Celiac Disease Program at Boston Children's Hospital offers diagnosis, and treatment of celiac disease. Our experts are some of the best in the country in diagnosing and helping families manage celiac disease with a gluten-free lifestyle. We also have a support group for families and a Celiac Family Health Education resource.

Celiac disease is an autoimmune disorder that results in damage to the small intestine, keeping it from properly absorbing food and nutrients. Celiac disease is treated with a permanent gluten-free diet.


Center for Motility and Functional Gastrointestinal Disorders

The Motility Center at Boston Children's Hospital is a subspecialty program within the Division of Gastroenterology. Our mission is to provide state of the art care and evaluation to children with motility and functional bowel disorders, and to their families. We evaluate and manage infants, children, adolescents and young adults with a wide variety of disorders resulting from abnormal motility or sensation of the gastrointestinal tract. Patients with motility disorders are referred to our center from New England, all of the United States and from around the world. The Center also has a large educational and research component.


Gastroenterology Procedure Unit

The Gastroenterology Procedure Unit (GPU) at Children?s Hospital Boston is a full-service unit providing an array of diagnostic and therapeutic endoscopy procedures in a safe, comfortable environment.

Our expert team works closely with other departments and divisions in the hospital, accommodating both routine and urgent care in a timely fashion. Patients are generally referred to the GPU through Children?s Department of Gastroenterology.

The digestive disorders program was recently ranked #1 in the country by U.S.News & World Report.


Liver Transplant Program

The Pediatric Liver Transplant Program at Boston Children's Hospital evaluates children who are potential candidates for transplantation, and manages the care of children who have received transplanted livers. A liver transplant is an operation performed to replace a diseased liver with a healthy one from another person.

Since the program's inception in 1984, Children's has performed more than 140 liver transplants and offers expertise in deceased whole organ transplants, reduced-size liver transplants, split liver transplants and related living donor transplants.


Center for Continence of Urine and Bowel (CUB)

The Continence of Urine and Bowel (CUB) Program at Boston Children's Hospital is a unique multidisciplinary program designed to coordinate the care of children with urine and bowel incontinence resulting from congenital anomalies, such as anorectal, spinal, neuromuscular or urological malformations.

The CUB program takes a multidisciplinary approach to treating these complex issues, which often require a child to be under the care of many specialists at one time.

Through the CUB program, each patient is evaluated by a team of specialists from various departments, including Gastroenterology, General Surgery, Neurosurgery and Urology, all in one visit. Other departments, such as Behavioral Medicine, Radiology and Orthopedics, are frequently consulted as well. The specialists then meet collectively to assess, diagnose and evaluate the children, and implement a multi-faceted care plan that addresses each patient's needs, and ensures the highest level of care for every child. State of the art diagnostic testing and therapy is provided. The CUB Program has extensive experience in the treatment and follow up of children that have undergone appendicostomies.


Clinical Nutrition Service

The Clinical Nutrition Service (CNS) at Boston Children's Hospital provides comprehensive nutrition consultation services for patients of all ages in both the inpatient and ambulatory (outpatient) settings. Using innovative diagnostic and evaluation techniques, our staff develops appropriate nutrition plans for infants, children and adolescents who suffer from a variety of disorders.


Growth and Nutrition Program

The Growth and Nutrition Program at Children's was established in July of 1984. It was one of the first multidisciplinary team programs in the country to address the problem of childhood malnutrition, formerly known as Failure to Thrive. Our current Growth and Nutrition Program has been in continuous operation for twenty-three years with great successes. Our program is supported through a contract with the Department of Public Health which funds specific Growth and Nutrition sites throughout Massachusetts.


Center for Aero-Digestive Disorders (CADD)

The Center for Aero-Digestive Disorders (CADD) provides long-term care and state-of-the-art medical and surgical treatment to children with complex problems involving the airway, pulmonary and upper digestive tract.

The center is staffed by a multidisciplinary team of specialists from various fields who provide comprehensive assessment, treatment and follow-up.


Center for Advanced Intestinal Rehabilitation

The Center for Advanced Intestinal Rehabilitation (CAIR) at Boston Children's Hospital is one of the world's premier programs for the treatment of short bowel syndrome, a complex and often devastating disorder caused by the loss of part of the small bowel. Treatment options may include nutritional management, medical services or surgical services.

Intestine and Multivisceral Transplant Program

The Intestine and Multivisceral Transplant Program at Boston Children's Hospital evaluates children who are potential candidates for small intestine transplantation, small intestine/liver transplantation, and multivisceral transplanation and manages the care of children who have received these transplants.

A multivisceral transplant is an operation in which multiple organs are transplanted, such as the stomach, pancreas, liver and small intestine.

General Clinical Research Center (GCRC)

The General Clinical Research Center, continuously funded by the National Institutes of Health since 1964, serves as the central focus of clinical research at Boston Children's Hospital. Its mission is to provide an optimal setting for multidisciplinary clinical research, therefore ensuring the timely translation of scientific knowledge into effective patient care. Centrally located on the CHB campus in the Main Building (6 East), the GCRC is an eight-bed unit organized to support the care of children involved in clinical research. All patient rooms have accommodations for one parent to stay overnight with their child. The unit has a well-equipped treatment room, medication room, play-activity area, dining room and nourishment center. A metabolic kitchen that supports our protocol needs is also located on 6 East. Ambulatory GCRC for outpatient research visits is located adjacent to the inpatient unit on Pavilion 6. Support provided by the GCRC includes a Core Laboratory, and Informatics, Biostatistics, Nutrition, and Phenotype/Genotype Core Programs.

Currently, the GCRC supports 140 active protocols involving 75 different investigators representing 21 of the Hospital's departments and divisions. There is a major effort to train and mentor young clinical investigators.

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