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Juvenile Arthritis

Next-Generation Sequencing Reveals Restriction and Clonotypic Expansion of Treg Cells in Juvenile Idiopathic Arthritis

Authors: Henderson LA, Volpi S, Frugoni F, Janssen E, Kim S, Sundel RP, Dedeoglu F, Lo MS, Hazen MM, Beth Son M, Mathieu R, Zurakowski D, Yu N, Lebedeva T, Fuhlbrigge RC, Walter JE, Nee Lee Y, Nigrovic PA, Notarangelo LD.

Summary: Dr. Henderson and colleagues collected blood and synovial fluid samples from children with juvenile idiopathic arthritis who were seen at Boston Children’s Hospital. Next generation sequencing technology was used to study the receptors on T cells, immune cells that may drive arthritis. T cells found in the blood and joints of children with arthritis had an abnormal array of T cell receptors. This study helps us better understand the characteristics of T cells in the joints of children with arthritis and supports the hypothesis that T cells are important in driving disease.

Publication Information: Arthritis and Rheumatology, July 2016

Frequency and Morbidity of Temporomandibular Joint Involvement in Adult Patients with a History of Juvenile Idiopathic Arthritis

Authors: Resnick CM, Dang R, Henderson LA, Zander DA, Daniels KM, Nigrovic PA, Kaban LB

Summary: Dr. Resnick, an oral surgeon at Boston Children’s Hospital, worked with a team of radiologists and pediatric rheumatologists to study the frequency of jaw joint involvement in juvenile idiopathic arthritis. Adults who were once patients with juvenile arthritis and cared for at Boston Children’s Hospital were studied. These patients were found to have high rates of jaw joint involvement even though many study subjects did not have jaw pain or symptoms as a child. This study highlights the importance of screening and monitoring children with arthritis for jaw involvement.

Publication Information: Journal of Oral and Maxillofacial Surgery, December 2016

Quantifying Temporomandibular Joint Synovitis in Children with Juvenile Idiopathic Arthritis

Authors: Resnick CM, Vakilian PM, Breen M, Zurakowski D, Caruso P, Henderson L, Nigrovic PA, Kaban LB, Peacock ZS. 

Summary: Dr. Resnick, an oral surgeon at Boston Children’s Hospital, worked with a team of radiologists and pediatric rheumatologists to study a new MRI technique that can be used to quantify jaw joint arthritis. The authors found the technique to be a promising radiographic method to study the jaw.

Publication Information:  Arthritis Care and Research, December 2016


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