Research

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Juvenile Arthritis

Biological Phenotyping of Juvenile Arthritis

What is the goal of the study? This study seeks to collect pre-treatment biosamples from patients with new-onset Juvenile Idiopathic Arthritis (JIA) to enable related translational research.

How do you participate? Patients with previously untreated JIA, other forms of arthritis that started before age 18, and healthy controls are enrolled. Prior to beginning treatment, individuals who consent to participate provide a single blood sample and synovial fluid sample that may be left over from a joint procedure. For more information, ask your Rheumatologist or contact the study coordinator.

Study Coordinator: Kacie Hoyt

Email: kacie.hoyt@childrens.harvard.edu

Phone: 617-919-2566

First-line Options in Systemic Juvenile Idiopathic Arthritis Treatment (FROST)

What is the goal of the study? This study aims to identify the safest and most effective therapy for patients who have been newly-diagnosed with Systemic Juvenile Idiopathic Arthritis (sJIA).

How do you participate? Patients with sJIA who consent to participate in the observational CARRA Registry are treated according to the most appropriate strategy recommended by their doctor. After beginning treatment, the patient’s short- and long-term outcomes are compared with patients treated differently all across the US and Canada. For families that provide additional consent, a set of blood samples is obtained for research before starting therapy and again after 6 months of therapy. For more information, ask your Rheumatologist or contact the study coordinator.

Study Coordinator: Ed Anderson

Email: edwin.anderson@childrens.harvard.edu

Phone: 617-355-6117

TMJ-Only Juvenile Idiopathic Arthritis versus Idiopathic Condylar Resorption: Are they the same?

What is the goal of the study? This study aims to compare patients with Juvenile Idiopathic Arthritis (JIA) with effects limited to the Temporomandibular Joints (TMJ) to those with Idiopathic Condylar Resorption (ICR) to determine if these represent the same disease process.

How do you participate? Patients who have TMJ-only-JIA and ICR that have sought treatment at Boston Children’s Hospital give consent for researchers to review their medical records to collect information to test for associations with their diagnosis. For more information, ask your physician or contact the study coordinator.

Study Coordinator: Carly Calabrese 

Email: carly.calabrese@childrens.harvard.edu

Phone: 617-919-1488

Identifying Predictors of Future TMJ Destruction at the Time of JIA Diagnosis

What is the goal of the study? This study aims to identify predictors associated with Temporomandibular Joint (TMJ) involvement in patients with Juvenile Idiopathic Arthritis (JIA), so that risk of TMJ involvement can be anticipated/assessed at JIA diagnosis.

How do you participate? Patients who have JIA and TMJ involvement that have been treated at Boston Children’s Hospital give consent for researchers to review their medical records to collect information that may be associated with TMJ involvement. For more information, ask your physician or contact the study coordinator.

Study Coordinator: Carly Calabrese 

Email: carly.calabrese@childrens.harvard.edu

Phone: 617-919-1488


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