Course participants will understand the principles of economic evaluation in health care research. We will start with a description of the different types of evaluation, existing guidelines and decision makers’ expectations for what evaluations should include. The major steps in the planning of an economic evaluation will be then discussed. The second lecture will focus entirely on the principles of cost-effectiveness analysis (CEA), measurement of health-related quality of life and quality-adjusted life years and estimation of incremental cost-effectiveness. During the third lecture participants will become familiar with various data sources that can be used for economic evaluations, and the basic principles of analysis of economic data. Participants will be introduced to economic models as an alternative to the more traditional clinical research design. Prior experience with statistical analysis is not expected. This course will be most useful to principle investigators, co-investigators, or analysts who are considering economic evaluations as part of their research.