At Boston Children's Hospital, our ultimate goal is to ensure long-term graft survival following solid organ transplantation. This goal is achieved through the use of innovative new surgical techniques and new immunosuppressive medications that preserve organ function while allowing children to grow and develop as healthy adolescents and adults following transplantation. The Pediatric Transplant Center is home to world-class transplant teams who perform cutting-edge clinical trials to evaluate the effectiveness of new treatments and approaches to care.
To maximize our potential to accelerate discovery and ultimately to improve care, the Department of Medicine at Children's launched a Transplant Research Program. The focus of the program is to perform basic research to further understand the molecular basis for chronic allograft rejection in children, the leading cause of graft failure following transplantation.
Members of the Transplant Research Program have opportunities to interact with clinical programs, both locally and nationally, which allow the development of candidate biomarkers as a new tool to monitor for early signs of chronic rejection, before it is too late to treat. Faculty within the Program are also assessing new avenues of research that challenge existing paradigms and some have discovered roles for new cells and molecules that have potential to change our approaches to therapy.
To learn about the research each of faculty within the program are doing, see our Faculty Research page or read either Dr. Briscoe's article or Dr. Daly's article on TransplantTalk.
Principal investigators in the Transplant Research Program
Front row: Natasha Frank, MD; Kevin Daly, MD; Soumitro Pal, PhD
Back row: Gary Visner, DO; David Briscoe, MB, ChB; Markus Frank, MD (not shown: Paolo Fiorina, MD, PhD)