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News About TNC Faculty

TNC Newsletters:
Volume 1: January 2015
Volume 2: July 2015
Volume 3: February 2016
Volume 4: September 2016

Impaired Recycling of Mitochondria in Autism: October 2016
Medical Press - 
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Advances and Future Directions for Tuberous Sclerosis Complex Research: 2016
Pediatric Neurology
Recommendations from the 2015 Strategic Planning Conference - Read More

The Genetics of Early-Onset Psychosis: Could it Aid Understanding of Schizophrenia? 
Vector Blog
Delving Into DNA (Robin Kleiman, PhD) - Read More

Sturge-Weber Foundation Research Award: May 11, 2016 -- The Sturge-Weber Foundation has named Lan Huang, PhD, of Boston Children's Hospital the recipient of the inaugural Lisa's Sturge-Weber Research Fellowship Award. Read More

Data Gaps Limit The Translational Potential of Pre-clinical Research: 
Science Translational Medicine
Robin Kleiman, PhD and colleague Michael D. Ehlers, MD, PhD, Chief Scientific Officer of the Neuroscience & Pain Research Unit, Pfizer Inc., review the lack of published preclinical data regarding the selection of dosing regimens in neuroscience and propose alternatives to current study designs. Read More

Emerging Knowledge In Neurodevelopmental Disorders:
Mustafa Sahin, MD, PhD and colleague Mriganka Sur, PhD, Director of the Simons Center for the Social Brain at MIT, discuss the progress made and obstacles faced in neurodevelopmental disorders research and the importance of addressing the neural circuitry, cell types and common signaling pathways in order to leverage the heterogeneity of these disorders into precision medicine. Read More 

Tuberous Sclerosis: Clinical Trial May Be What Halted Charlotte’s Seizures:
Thriving, Boston Children's Hospital's Pediatric Health Blog
A profile of a child with tuberous sclerosis complex involved in a Boston Children’s clinical trial to investigate the effect of a study drug (everolimus) on seizures. Read More

A Drug for Autism?
The Boston Globe
Profiles of children with tuberous sclerosis complex involved in a Boston Children’s clinical trial to investigate whether the study drug (everolimus) can improve neurocognition. Read More

Boston Children’s Hospital Launches New Multi-disciplinary Translational Neuroscience Center (TNC):
Autism Consortium (blog)
Leading physicians and scientists at Boston Children’s Hospital (BCH) formed the collaborative Translational Neuroscience Center (TNC) in January to improve the lives of children and adolescents with brain and other nervous system disorders. Mustafa Sahin, MD, PhD, an autism researcher and director of the TNC, told the Autism Consortium recently that one of the Center’s first goals will be accelerating the discovery of drugs and other new interventions for children with autism spectrum disorder.

Autism’s Unexpected Link to Cancer Genes:
The New York Times
Mutations in rare disease genes, PTEN and TSC, can cause the development of tumors as well as autism. Research is actively underway to discover treatments for both conditions. Read More

Selectively Silencing Itch: Itch-specific Nerves Let In Relief:
Vector, Boston Children’s Hospital’s Science and Clinical Innovation Blog
The lab of Clifford Woolf, MB, BCh, PhD, has found distinct sets of itch-generating neurons, explaining why current itch therapies often fail and suggesting new ways to curb itch selectively. Read More

Scientists Begin To Unravel Long-term Effects of Early Adversity:
The Boston Globe
Researchers are making new findings as to how social isolation early in life not only affects behavioral development but cognitive development as well. Read More

Genetic Studies Find Root Causes of Epilepsy:
Vector, Boston Children’s Hospital’s Science and Clinical Innovation Blog
Ann Poduri, MD, is mapping genetic causes of hemimegalencephaly, Ohtahara syndrome and other rare epilepsy conditions. Her findings suggest new treatment approaches, perhaps for more common forms of epilepsy. Read More

A New Era in Spinal Muscular Atrophy:
Nature Medicine
Basil Darras, MD, is leading the Boston Children’s arm of a Phase I clinical trial of a targeted treatment for SMA: ISIS-SMNRx. The drug, administered intrathecally, compensates for loss or damage to the SMN1 gene by boosting activity of a backup copy of SMN2. Read More

Visionary Research on Rett Syndrome:
Vector, Boston Children’s Hospital’s Science and Clinical Innovation Blog
Animal studies suggest a target for undoing damage to brain circuits in Rett syndrome and raise the question of whether vision could serve as proxy for evaluating brain function. Read More

Using Stem Cells to Find Autism Treatments:
Vector, Boston Children’s Hospital’s Science and Clinical Innovation Blog
In a four-way collaboration between Boston Children’s, the Harvard Stem Cell Institute, Harvard Medical School and Roche, skin cells from patients with autism will be used to make pluripotent stem cells, which will in turn be made into neurons for clinical evaluation and drug testing. Read More

A Better Test for Finding Autism Genes?
Results from a joint study conducted by the Autism Consortium and Boston Children’s reveal that a secondary approach to testing for autism may be more efficient than the current primary approaches. The test, called chromosomal microarray analysis, has detected the underling genetic cause of 7 percent of autism cases. Read More

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