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Clinical Cores

Human Neurobehavioral Core Service

The goal of the Neurobehavioral Core is to improve access to and expand behavioral assessment resources for translational neuroscience research at Boston Children’s Hospital. The core represents a collaboration between the Laboratories of Cognitive Neuroscience in the Division of Developmental Medicine and the Clinical Behavioral Science Core in the Department of Psychiatry. This TNC core aims to offer a standardized set of state-of-the-art assessments of children—from infancy to young adults. 

The core directors will also provide guidance for researchers on:

  • which standardized tests are likely to provide the best information for a particular clinical research study
  • which specialized laboratories at Boston Children’s might provide novel tests 
  • which specialized tests are available at other local institutions in Boston
  • how to approach the development of a new test
  • which tests might provide the best translation from animal studies to human studies

Repository Core for Neurological Disorders: (Click Here For More Information)
The Repository Core for Neurological Disorders is a Children’s Hospital Boston database and biological specimen bank that pairs biological samples with phenotypic data for translational research and clinical trials. To better understand causes and create new therapies for neurological disorders, it is often necessary for researchers to investigate various patients with the same or similar conditions. Therefore, such studies can benefit immensely from access to a database of high-quality clinical data and paired DNA and protein samples from affected individuals. This database and bio-specimen bank can save both time and resources that would be required to collect these data independently. As a result, all data, DNA and other bio-samples will be stored indefinitely and will potentially be used by multiple investigators for future studies of the causes and/or treatment of neurological disorders. The Core is anticipated to lead to new and enhanced collaborations among users, including collaborations between those who submit and those who access the data, between those who analyze the data with different primary goals, and between those using this and other Cores. Any patient with a neurological disorder and their family members are eligible to participate.

Neuromuscular Clinical Evaluation
The Neuromuscular Clinical Evaluation Service builds upon the Boston Children’s Neuromuscular Center clinical research efforts including participation in the NINDS Network for Excellence in Neuroscience Clinical Trials (NeuroNEXT) and the Pediatric Neuromuscular Clinical Research Network (PNCR).  The TNC’s Neuromuscular Clinical Evaluation Service provides expertise in the development and administration of numerous motor function measures including  Myometry, North Star Ambulatory Assessment, walk tests and upper limb assessments. In addition, the service provides consultation and services on quantitative outcome measures including Compound Motor Action Potential (CMAP), Motor Unit Number Estimation (MUNE), Electrical Impedance Myography (EIM), Quantitative Ultrasound and Biochemical Biomarkers of SMA.

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