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Inflammatory Bowel Disease Treatment Publications

1: Goettel JA, Gandhi R, Kenison JE, Yeste A, Murugaiyan G, Sambanthamoorthy S,

Griffith AE, Patel B, Shouval DS, Weiner HL, Snapper SB, Quintana FJ. AHR

Activation Is Protective against Colitis Driven by T Cells in Humanized Mice.

Cell Rep. 2016 Oct 25;17(5):1318-1329. doi: 10.1016/j.celrep.2016.09.082. PubMed

PMID: 27783946.

2: Shouval DS, Biswas A, Kang YH, Griffith AE, Konnikova L, Mascanfroni ID, Redhu

NS, Frei SM, Field M, Doty AL, Goldsmith JD, Bhan AK, Loizides A, Weiss B,

Yerushalmi B, Yanagi T, Lui X, Quintana FJ, Muise AM, Klein C, Horwitz BH, Glover

SC, Bousvaros A, Snapper SB. Interleukin 1 Beta Mediates Intestinal Inflammation

in Mice and Patients with IL10 Receptor Deficiency. Gastroenterology. 2016 Sep

27. pii: S0016-5085(16)35035-1. doi: 10.1053/j.gastro.2016.08.055. PubMed PMID:

27693323.

3: Nelms BD, Waldron L, Barrera LA, Weflen AW, Goettel JA, Guo G, Montgomery RK,

Neutra MR, Breault DT, Snapper SB, Orkin SH, Bulyk ML, Huttenhower C, Lencer WI.

CellMapper: rapid and accurate inference of gene expression in

difficult-to-isolate cell types. Genome Biol. 2016 Sep 29;17(1):201. PubMed PMID:

27687735; PubMed Central PMCID: PMC5043525.

4: Lexmond WS, Goettel JA, Lyons JJ, Jacobse J, Deken MM, Lawrence MG, DiMaggio

TH, Kotlarz D, Garabedian E, Sackstein P, Nelson CC, Jones N, Stone KD, Candotti

F, Rings EH, Thrasher AJ, Milner JD, Snapper SB, Fiebiger E. FOXP3+ Tregs require

WASP to restrain Th2-mediated food allergy. J Clin Invest. 2016 Oct

3;126(10):4030-4044. doi: 10.1172/JCI85129. PubMed PMID: 27643438.

5: Shouval DS, Ebens CL, Murchie R, McCann K, Rabah R, Klein C, Muise AM, Snapper

SB. Large B-Cell Lymphoma in an Adolescent Patient With Interleukin-10 Receptor

Deficiency and History of Infantile Inflammatory Bowel Disease. J Pediatr

Gastroenterol Nutr. 2016 Jul;63(1):e15-7. doi: 10.1097/MPG.0000000000000532.

PubMed PMID: 27336593; PubMed Central PMCID: PMC4605893.

6: Snapper SB. Very-Early-Onset Inflammatory Bowel Disease. Gastroenterol Hepatol

(N Y). 2015 Aug;11(8):554-6. PubMed PMID: 27118953; PubMed Central PMCID:

PMC4843045.

7: Yanagi T, Mizuochi T, Takaki Y, Eda K, Mitsuyama K, Ishimura M, Takada H,

Shouval DS, Griffith AE, Snapper SB, Yamashita Y, Yamamoto K. Novel exonic

mutation inducing aberrant splicing in the IL10RA gene and resulting in

infantile-onset inflammatory bowel disease: a case report. BMC Gastroenterol.

2016 Jan 28;16:10. doi: 10.1186/s12876-016-0424-5. PubMed PMID: 26822028; PubMed

Central PMCID: PMC4730728.

8: Moran CJ, Klein C, Muise AM, Snapper SB. Very early-onset inflammatory bowel

disease: gaining insight through focused discovery. Inflamm Bowel Dis. 2015

May;21(5):1166-75. doi: 10.1097/MIB.0000000000000329. Review. PubMed PMID:

25895007.

9: Goettel JA, Biswas S, Lexmond WS, Yeste A, Passerini L, Patel B, Yang S, Sun

J, Ouahed J, Shouval DS, McCann KJ, Horwitz BH, Mathis D, Milford EL, Notarangelo

LD, Roncarolo MG, Fiebiger E, Marasco WA, Bacchetta R, Quintana FJ, Pai SY, Klein

C, Muise AM, Snapper SB. Fatal autoimmunity in mice reconstituted with human

hematopoietic stem cells encoding defective FOXP3. Blood. 2015 Jun

18;125(25):3886-95. doi: 10.1182/blood-2014-12-618363. PubMed PMID: 25833964;

PubMed Central PMCID: PMC4473116.

10: Uhlig HH, Schwerd T, Koletzko S, Shah N, Kammermeier J, Elkadri A, Ouahed J,

Wilson DC, Travis SP, Turner D, Klein C, Snapper SB, Muise AM; COLORS in IBD

Study Group and NEOPICS.. The diagnostic approach to monogenic very early onset

inflammatory bowel disease. Gastroenterology. 2014 Nov;147(5):990-1007.e3. doi:

10.1053/j.gastro.2014.07.023. Review. PubMed PMID: 25058236.

11: Wurbel MA, Le Bras S, Ibourk M, Pardo M, McIntire MG, Coco D, Geha RS,

Fiebiger E, Snapper SB. CCL25/CCR9 interactions are not essential for colitis

development but are required for innate immune cell protection from chronic

experimental murine colitis. Inflamm Bowel Dis. 2014 Jul;20(7):1165-76. doi:

10.1097/MIB.0000000000000059. PubMed PMID: 24874458.

12: Shouval DS, Biswas A, Goettel JA, McCann K, Conaway E, Redhu NS, Mascanfroni

ID, Al Adham Z, Lavoie S, Ibourk M, Nguyen DD, Samsom JN, Escher JC, Somech R,

Weiss B, Beier R, Conklin LS, Ebens CL, Santos FG, Ferreira AR, Sherlock M, Bhan

AK, Müller W, Mora JR, Quintana FJ, Klein C, Muise AM, Horwitz BH, Snapper SB.

Interleukin-10 receptor signaling in innate immune cells regulates mucosal immune

tolerance and anti-inflammatory macrophage function. Immunity. 2014 May

15;40(5):706-19. doi: 10.1016/j.immuni.2014.03.011. PubMed PMID: 24792912; PubMed

Central PMCID: PMC4513358.

13: Murugan D, Albert MH, Langemeier J, Bohne J, Puchalka J, Järvinen PM, Hauck

F, Klenk AK, Prell C, Schatz S, Diestelhorst J, Sciskala B, Kohistani N,

Belohradsky BH, Müller S, Kirchner T, Walter MR, Bufler P, Muise AM, Snapper SB,

Koletzko S, Klein C, Kotlarz D. Very early onset inflammatory bowel disease

associated with aberrant trafficking of IL-10R1 and cure by T cell replete

haploidentical bone marrow transplantation. J Clin Immunol. 2014 Apr;34(3):331-9.

doi: 10.1007/s10875-014-9992-8. PubMed PMID: 24519095.

14: Shouval DS, Ouahed J, Biswas A, Goettel JA, Horwitz BH, Klein C, Muise AM,

Snapper SB. Interleukin 10 receptor signaling: master regulator of intestinal

mucosal homeostasis in mice and humans. Adv Immunol. 2014;122:177-210. doi:

10.1016/B978-0-12-800267-4.00005-5. Review. PubMed PMID: 24507158; PubMed Central

PMCID: PMC4741283.

15: Zitomersky NL, Atkinson BJ, Franklin SW, Mitchell PD, Snapper SB, Comstock

LE, Bousvaros A. Characterization of adherent bacteroidales from intestinal

biopsies of children and young adults with inflammatory bowel disease. PLoS One.

2013;8(6):e63686. doi: 10.1371/journal.pone.0063686. PubMed PMID: 23776434;

PubMed Central PMCID: PMC3679120.

16: Garber JJ, Takeshima F, Antón IM, Oyoshi MK, Lyubimova A, Kapoor A, Shibata

T, Chen F, Alt FW, Geha RS, Leong JM, Snapper SB. Enteropathogenic Escherichia

coli and vaccinia virus do not require the family of WASP-interacting proteins

for pathogen-induced actin assembly. Infect Immun. 2012 Dec;80(12):4071-7. doi:

10.1128/IAI.06148-11. PubMed PMID: 22966049; PubMed Central PMCID: PMC3497443.

17: Nguyen DD, Wurbel MA, Goettel JA, Eston MA, Ahmed OS, Marin R, Boden EK,

Villablanca EJ, Paidassi H, Ahuja V, Reinecker HC, Fiebiger E, Lacy-Hulbert A,

Horwitz BH, Mora JR, Snapper SB. Wiskott-Aldrich syndrome protein deficiency in

innate immune cells leads to mucosal immune dysregulation and colitis in mice.

Gastroenterology. 2012 Sep;143(3):719-29.e1-2. doi: 10.1053/j.gastro.2012.06.008.

PubMed PMID: 22710191; PubMed Central PMCID: PMC3760724.

18: Westerberg LS, Dahlberg C, Baptista M, Moran CJ, Detre C, Keszei M, Eston MA,

Alt FW, Terhorst C, Notarangelo LD, Snapper SB. Wiskott-Aldrich syndrome protein

(WASP) and N-WASP are critical for peripheral B-cell development and function.

Blood. 2012 Apr 26;119(17):3966-74. doi: 10.1182/blood-2010-09-308197. PubMed

PMID: 22411869; PubMed Central PMCID: PMC3350364.

19: Ramasamy S, Nguyen DD, Eston MA, Alam SN, Moss AK, Ebrahimi F, Biswas B,

Mostafa G, Chen KT, Kaliannan K, Yammine H, Narisawa S, Millán JL, Warren HS,

Hohmann EL, Mizoguchi E, Reinecker HC, Bhan AK, Snapper SB, Malo MS, Hodin RA.

Intestinal alkaline phosphatase has beneficial effects in mouse models of chronic

colitis. Inflamm Bowel Dis. 2011 Feb;17(2):532-42. doi: 10.1002/ibd.21377. PubMed

PMID: 20645323; PubMed Central PMCID: PMC3154118.

20: Westerberg LS, Meelu P, Baptista M, Eston MA, Adamovich DA, Cotta-de-Almeida

V, Seed B, Rosen MK, Vandenberghe P, Thrasher AJ, Klein C, Alt FW, Snapper SB.

Activating WASP mutations associated with X-linked neutropenia result in enhanced

actin polymerization, altered cytoskeletal responses, and genomic instability in

lymphocytes. J Exp Med. 2010 Jun 7;207(6):1145-52. doi: 10.1084/jem.20091245.

PubMed PMID: 20513746; PubMed Central PMCID: PMC2882832.

21: Lyubimova A, Garber JJ, Upadhyay G, Sharov A, Anastasoaie F, Yajnik V,

Cotsarelis G, Dotto GP, Botchkarev V, Snapper SB. Neural Wiskott-Aldrich syndrome

protein modulates Wnt signaling and is required for hair follicle cycling in

mice. J Clin Invest. 2010 Feb;120(2):446-56. doi: 10.1172/JCI36478. PubMed PMID:

20071778; PubMed Central PMCID: PMC2810069.

22: Glocker EO, Kotlarz D, Boztug K, Gertz EM, Schäffer AA, Noyan F, Perro M,

Diestelhorst J, Allroth A, Murugan D, Hätscher N, Pfeifer D, Sykora KW, Sauer M,

Kreipe H, Lacher M, Nustede R, Woellner C, Baumann U, Salzer U, Koletzko S, Shah

N, Segal AW, Sauerbrey A, Buderus S, Snapper SB, Grimbacher B, Klein C.

Inflammatory bowel disease and mutations affecting the interleukin-10 receptor. N

Engl J Med. 2009 Nov 19;361(21):2033-45. doi: 10.1056/NEJMoa0907206. PubMed PMID:

19890111; PubMed Central PMCID: PMC2787406.

23: Adamovich DA, Nakamura F, Worth A, Burns S, Thrasher AJ, Hartwig JH, Snapper

SB. Activating mutations of N-WASP alter Shigella pathogenesis. Biochem Biophys

Res Commun. 2009 Jul 3;384(3):284-9. doi: 10.1016/j.bbrc.2009.04.050. PubMed

PMID: 19379711; PubMed Central PMCID: PMC2697925.

24: Nguyen DD, Snapper SB. Targeting Smads to restore transforming growth

factor-beta signaling and regulatory T-cell function in inflammatory bowel

disease. Gastroenterology. 2009 Apr;136(4):1161-4. doi:

10.1053/j.gastro.2009.02.024. PubMed PMID: 19236965.

25: Boden EK, Snapper SB. Regulatory T cells in inflammatory bowel disease. Curr

Opin Gastroenterol. 2008 Nov;24(6):733-41. Review. PubMed PMID: 19125486.

26: Westerberg LS, Klein C, Snapper SB. Breakdown of T cell tolerance and

autoimmunity in primary immunodeficiency--lessons learned from monogenic

disorders in mice and men. Curr Opin Immunol. 2008 Dec;20(6):646-54. doi:

10.1016/j.coi.2008.10.004. Review. PubMed PMID: 18955138; PubMed Central PMCID:

PMC2605935.

27: Stenson WF, Snapper SB. Challenges in IBD research: Assessing progress and

rethinking the research agenda. Inflamm Bowel Dis. 2008 May;14(5):687-708. doi:

10.1002/ibd.20371. Review. PubMed PMID: 18260124.

28: Cotta-de-Almeida V, Westerberg L, Maillard MH, Onaldi D, Wachtel H, Meelu P,

Chung UI, Xavier R, Alt FW, Snapper SB. Wiskott Aldrich syndrome protein (WASP)

and N-WASP are critical for T cell development. Proc Natl Acad Sci U S A. 2007

Sep 25;104(39):15424-9. PubMed PMID: 17878299; PubMed Central PMCID: PMC2000553.

29: Nguyen DD, Maillard MH, Cotta-de-Almeida V, Mizoguchi E, Klein C, Fuss I,

Nagler C, Mizoguchi A, Bhan AK, Snapper SB. Lymphocyte-dependent and Th2

cytokine-associated colitis in mice deficient in Wiskott-Aldrich syndrome

protein. Gastroenterology. 2007 Oct;133(4):1188-97. PubMed PMID: 17764675; PubMed

Central PMCID: PMC2048975.

30: Maillard MH, Snapper SB. Teaching tolerance with a probiotic antigen delivery

system. Gastroenterology. 2007 Aug;133(2):706-9. PubMed PMID: 17681187.

31: Maillard MH, Cotta-de-Almeida V, Takeshima F, Nguyen DD, Michetti P, Nagler

C, Bhan AK, Snapper SB. The Wiskott-Aldrich syndrome protein is required for the

function of CD4(+)CD25(+)Foxp3(+) regulatory T cells. J Exp Med. 2007 Feb

19;204(2):381-91. PubMed PMID: 17296786; PubMed Central PMCID: PMC2118715.

32: Snapper SB, Meelu P, Nguyen D, Stockton BM, Bozza P, Alt FW, Rosen FS, von

Andrian UH, Klein C. WASP deficiency leads to global defects of directed

leukocyte migration in vitro and in vivo. J Leukoc Biol. 2005 Jun;77(6):993-8.

PubMed PMID: 15774550.

33: Cotta-de-Almeida V, Schonhoff S, Shibata T, Leiter A, Snapper SB. A new

method for rapidly generating gene-targeting vectors by engineering BACs through

homologous recombination in bacteria. Genome Res. 2003 Sep;13(9):2190-4. PubMed

PMID: 12915491; PubMed Central PMCID: PMC403727.

34: Snapper SB, Rosen FS. A family of WASPs. N Engl J Med. 2003 Jan

23;348(4):350-1. Review. PubMed PMID: 12540651.

35: Klein C, Nguyen D, Liu CH, Mizoguchi A, Bhan AK, Miki H, Takenawa T, Rosen

FS, Alt FW, Mulligan RC, Snapper SB. Gene therapy for Wiskott-Aldrich syndrome:

rescue of T-cell signaling and amelioration of colitis upon transplantation of

retrovirally transduced hematopoietic stem cells in mice. Blood. 2003 Mar

15;101(6):2159-66. PubMed PMID: 12433691.

36: Shibata T, Takeshima F, Chen F, Alt FW, Snapper SB. Cdc42 facilitates

invasion but not the actin-based motility of Shigella. Curr Biol. 2002 Feb

19;12(4):341-5. PubMed PMID: 11864577.

37: Snapper SB, Takeshima F, Antón I, Liu CH, Thomas SM, Nguyen D, Dudley D,

Fraser H, Purich D, Lopez-Ilasaca M, Klein C, Davidson L, Bronson R, Mulligan RC,

Southwick F, Geha R, Goldberg MB, Rosen FS, Hartwig JH, Alt FW. N-WASP deficiency

reveals distinct pathways for cell surface projections and microbial actin-based

motility. Nat Cell Biol. 2001 Oct;3(10):897-904. PubMed PMID: 11584271.

38: Bauch A, Alt FW, Crabtree GR, Snapper SB. The cytoskeleton in lymphocyte

signaling. Adv Immunol. 2000;75:89-114. Review. PubMed PMID: 10879282.

39: Snapper SB, Rosen FS. The Wiskott-Aldrich syndrome protein (WASP): roles in

signaling and cytoskeletal organization. Annu Rev Immunol. 1999;17:905-29.

Review. PubMed PMID: 10358777.

40: Snapper SB, Rosen FS, Mizoguchi E, Cohen P, Khan W, Liu CH, Hagemann TL, Kwan

SP, Ferrini R, Davidson L, Bhan AK, Alt FW. Wiskott-Aldrich syndrome

protein-deficient mice reveal a role for WASP in T but not B cell activation.

Immunity. 1998 Jul;9(1):81-91. PubMed PMID: 9697838.

41: Snapper SB, Syngal S, Friedman LS. Ulcerative colitis and colon cancer: more

controversy than clarity. Dig Dis. 1998 Mar-Apr;16(2):81-7. Review. PubMed PMID:

9571373.

42: Snapper SB, Melton RE, Mustafa S, Kieser T, Jacobs WR Jr. Isolation and

characterization of efficient plasmid transformation mutants of Mycobacterium

smegmatis. Mol Microbiol. 1990 Nov;4(11):1911-9. PubMed PMID: 2082148.

43: Snapper SB, Lugosi L, Jekkel A, Melton RE, Kieser T, Bloom BR, Jacobs WR Jr.

Lysogeny and transformation in mycobacteria: stable expression of foreign genes.

Proc Natl Acad Sci USA. 1988 Sep;85(18):6987-91. PubMed PMID: 2842799; PubMed

Central PMCID: PMC282104.

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