Research

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Faculty

P. Ellen Grant, MD
Director, FNNDSC
Associate Professor of Radiology

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Department

Newborn Medicine and Radiology

Hospital Title

Director, FNNDSC

Academic Title

Associate Professor of Radiology, HMS

Phone

857-218-5111

Fax

617-730-4671

Email

Ellen Grant

Location

1 Autumn Street
Boston, MA 02215

Dr. Grant is the Founding Director of the Fetal-Neonatal Neuroimaging and Developmental Science Center. She holds a Master of Science degree in physics and an MD from the University of Toronto. She did her radiology residency at Vancouver General Hospital in British Columbia, Canada, and her fellowship in adult and pediatric neuroradiology at the University of California, San Francisco. She is now an associate professor of radiology at the Harvard Medical School.

Dr. Grant headed the Division of Pediatric Radiology at Massachusetts General Hospital for five years before moving to Boston Children's Hospital to become the founding director of the Fetal-Neonatal Neuroimaging and Developmental Science Center and the first incumbent of Boston Children's Hospital Chair in Neonatology. At Children's she holds appointments in the Division of Newborn Medicine and the Department of Radiology.

Dr. Grant is a co-author of two popular textbooks for clinical neuroradiology and has won a number of awards for her research efforts as well as recognition for her clinical excellence.

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Stephanie Jones, PhD
Associate Scientific Research Staff
Instructor in Pediatrics

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Department

Newborn Medicine and Radiology

Hospital Title

Instructor in Pediatrics

Academic Title

Associate Scientific Research Staff

Phone

617-724-2384
617-921-2412 (cell)

Fax

Fax 617-730-4671

Email

Stephanie Jones

Location

1 Autumn Street
Boston, MA 02215

Dr. Jones uses her background in dynamical systems theory mathematics and computational neural modeling to study neural dynamics in health and disease. She is trained in MEG/EEG imaging and currently uses computational modeling techniques to bridge the critical gap between the non-invasive imaging observables and the underlying microscopic cellular and network level mechanisms.

Her current projects and interest include:

  • Investigating the neural dynamics underlying normal development in children ages 0-6 as well as neural abnormalities in children with encephalopathy of prematurity (EP). In collaboration with Drs. Ellen Grant and Yoshio Okada at CHB, we are studying development with a powerful combination of techniques including mathematical modeling, MR diffusion tensor imaging, MEG imaging,
  • Studying the mechanisms and functions of neural rhythms including their role in sensory perception, attentional processes, and healthy aging. We are also investigating the source of disruption in brain rhythms in diseases such as Parkinson’s Disease, Obsessive Compulsive Disorder, and Attention Deficit Disorder.
  • Investigating plasticity induced by training in perceptual attention. In collaboration with Dr. Cathy Kerr at HMS we are studying neurodynamics underlying Mindfulness Medidation Practice.
  • Combing computational modeling and optogenetic techniques, in collaboration with Dr. Chris Moore at Brown University, to study neural dynamics. We are currently delineating the role of specific cell types in controlling neocortical rhythmicity and investigating the impact of these rhythms on sensory perception.

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Yoshio Okada, PhD
MEG Program Director, FNNDSC
Clinical Professor of Neurology

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Department

Neurology

Hospital Title

MEG Program Director, FNNDSC

Academic Title

Clinical Professor of Neurology

Phone

781-216-1143

Fax

617-730-4671

Email

Yoshio Okada

Location

1 Autumn Street
Boston, MA 02215

Dr. Okada’s research interest is in the area of human brain development, especially functional development. He uses magnetoencephalography (MEG) and electroencephalography (EEG) to study the electrophysiology, electroculography and infrared eye movement monitor to study control of eye movements by the brain, magnetic resonance imaging (MRI) to study the anatomical development accompanying the functional development, mathematical techniques to image activities in the brain and mathematical models of the cortical circuit to interpret MEG and EEG signals. He uses these techniques to understand the normal development of the human brain in the area of perception and cognition, and also to understand how the normal development is altered in patients with various neurological disorders including cerebral palsy, autism, epilepsy, Down Syndrome, hearing impairment and deafness, visual impairment and blindness. He is also interested in developing methods of rehabilitation to help children with movement impairments due to trauma or cerebral palsy.

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Christos Papadelis, PhD
MEG Lab Manager
Instructor in Neurology

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Department

Neurology

Hospital Title

Research Associate

Academic Title

Instructor in Neurology

Phone

781-216-1128

Fax

781-216-1172

Email

Christos Papadelis

Location

9 Hope Avenue
Waltham, MA 02453

Christos Papadelis is Instructor in Neurology at Harvard Medical School, Research Associate at Boston Children’s Hospital, and Manager of BabyMEG laboratory.  He received the diploma in Electrical Engineering from the Aristotle University of Thessaloniki, Greece, in 1998, and his MSc and PhD in Medical Informatics, in 2001 and 2005 respectively, from the same institution.  During his graduate studies, he worked on a number of research projects funded from the European Union, and the Greek Secretariat for Research and Technology.  After his PhD graduation, he worked as Post-Doc Researcher in the Laboratory of Human Brain Dynamics at Brain Science Institute (BSI) of RIKEN, Japan, from June 2005 to August 2008, and in the Center for Mind/Brain Sciences (CIMeC) at University of Trento, Italy, from September 2008 to August 2011.

His main research goal is to understand how different sensory and motor processes of the cerebral cortex are integrated to achieve goal-directed behaviors using distributed synchronized neural networks of oscillatory activity.  He is currently working on understanding how large-scale cortical networks are formed during human development.

Dr. Papadelis is an Associate Editor for the Journal of Information Technology Research (JITR), Guest Editor for Biomedical Signal Processing and Control, and reviewer for more than ten peer-reviewed journals such as Neuroimage, Brain Research, Journal of Sleep Research, and others.  He has published more than 20 papers in peer-reviewed journals, and figures of his work have been selected as covers for multiple scientific journals.

Dr. Papadelis is married to Yulia Kotelnikova, and has a daughter.

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Rudolph Pienaar, PhD
Technical Director, FNNDSC
Instructor in Radiology

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Department

Radiology

Hospital Title

Technical Director and Staff Scientist, FNNDSC

Academic Title

Instructor in Radiology, HMS

Phone

857-218-5139

Fax

617-730-4671

Email

Rudolph Pienaar

Location

1 Autumn Street
Boston, MA 02215

Dr. Pienaar received his Bachelors and Masters Degrees in Electronic Engineering at the University of Pretoria, South Africa before completing a Doctoral Degree in Applied Biomedical Engineering at the Cleveland Clinic Foundation / Cleveland State University. As Technical Director of the FNNDSC, he is responsible for the neuro-radiological computational research infrastructure, which includes the first high performance compute cluster established at the CHB. He is interested in understanding the normal development of the brain as expressed in its folding and complex internal connectivity architecture. Rudolph also works actively to try to bridge the gap between the research and clinical worlds by helping design and deploy web-based research imaging tools.

His Research Interests include:

  • Cortical surface reconstructions from structural MRI
  • Curvature and shape analysis
  • Connectivity and relationships with physical shape of brain
  • High performance scientific computing tool development and deployment

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Emi Takahashi, PhD
Associate Scientific Research Staff
Assistant Professor in Pediatrics

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Department

Newborn Medicine

Hospital Title

Associate Scientific Research Staff

Academic Title

Assistant Professor in Pediatrics

Phone

857-218-5141

Fax

617-730-4671

Email

Emi Takahashi

Location

1 Autumn Street
Boston MA 02215

Dr. Takahashi trained as a medical student for five years and then received her Ph.D. in Neuroscience from Chiba University School of Medicine in Japan. She began pursuing interests in non-invasive imaging of brain function and anatomical connectivity at Boston University School of Medicine. During this time, she studied whole brain anatomical connectivity related to long-term memory systems using diffusion tractography and functional imaging. She then pursued an interest in high-resolution diffusion imaging of whole brain connectivity, especially of the developing brain at Massachusetts General Hospital and Boston Children's Hospital.

Dr. Takahashi is currently working on an analysis of connectivity in the developing brains of humans and animals, from the fetus to the young adult. She is also examining the relationship of this connectivity to emerging gyral morphometry, and using histological techniques to confirm her results. Her long-term research goal is to understand the uniqueness of human brain development, mainly by applying and further improving diffusion MRI techniques with combining additional methods.

  • Application of diffusion tractography to the study of brain connectivity in humans and animals.
  • Development of brain connectivity ranging from the fetus to young adult.
  • Relationships between white matter development and emerging brain functions.
  • Comparative brain connectivity study on developing brains across species.

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Mathieu Dehaes, PhD
Associate Scientific Research Staff
Instructor in Pediatrics

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Department

Newborn Medicine

Hospital Title

Research Associate

Academic Title

Instructor in Neurology

Phone

857-218-5142

Fax

617-730-4671

Email

Mathieu Dehaes

Location

1 Autumn Street
Boston MA 02215

Dr. Dehaes' research interests include:

  • Brain imaging, brain development, brain injury, cerebral oxygen consumption and metabolism
  • Hypoxic ischemic encephalopathy, prematurity, congenital heart disease and cerebral palsy

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    Kiho Im, PhD
    Associate Scientific Research Staff
    Instructor in Pediatrics

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    Department

    Neurology

    Hospital Title

    Research Associate

    Academic Title

    Instructor in Neurology

    Phone

    781-216-1128

    Fax

    781-216-1172

    Email


    Location

    9 Hope Avenue
    Waltham, MA 02453

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