Research

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Cancer

Cancer
  • About 85-90 percent of children with ALL are cured today, but about 10 to 20 percent suffer relapses, which are much more difficult to treat. Using a genomic approach, our researchers have found that the drug everolimus may be able to circumvent relapsed ALL's treatment resistance. Read more.
  • Brain tumors like gliomas are quite adept at deceiving the immune system. A new cancer vaccine strategy that combines immunotherapy, gene therapy and antiviral therapy to unmask gliomas and make them vulnerable to attack by a patient's immune system. Read more.
  • Medulloblastoma, the most common malignant brain tumor of childhood, is actually four separate diseases, each with a unique molecular fingerprint and distinct survival curve. Our researchers have found the gene mutations responsible for the four fingerprints: a first step toward personalized therapy for these tumors. Read more.
  • For 40 years, a rare brain tumor called diffuse intrinsic pontine glioma has been impossible to biopsy, leaving researchers and doctors without any knowledge of how best to treat it. Recent advances in neurosurgery and cancer biology have led to a new clinical trial that could result in new targeted treatments for this mysterious tumor. Read more.

Cancer survivorship

  • Fertility is a concern for all survivors of childhood cancer. Our researchers are working on new biomarkers for gauging a girl's risk of infertility before treatment, and on techniques for isolating sperm stem cells from boys for potential later sperm production. Read more.
  • Children with brain tumors often face their own unique challenges after treatment. Our Stop & Shop Family Pediatric Neuro-oncology Outcomes Clinic conducts clinical studies focused on the needs of pediatric brain tumor survivors of all ages. Read more.
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