Genetically Engineered Zebrafish

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Dr. Leonard Zon, along with postdoctoral fellow Dr. Elizabeth Patton and colleagues, genetically engineered this zebrafish to make the mutated form of human BRAF, which caused the fish to develop black-pigmented moles on its skin. 

When the fish were also made to be deficient for a gene called p53, which suppresses tumor growth, the moles developed into invasive melanomas resembling human cancers. The researchers' findings appear in the February 8th, 2005 issue of Current Biology.


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