Enrique Cobos del Moral PhD

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Research Fellow

Background and Research Interests
I received my B.Sc. in Biology (1999) at the University of Jaén (Spain), and a B.Sc. in Biochemistry (2001) at the University of Granada (Spain). I obtained my PhD in Pharmacology (2006), under the supervision of Prof. Baeyens and Dr. del Pozo in the Faculty of Medicine of the University of Granada.

As part of my doctoral thesis, I studied the binding properties of several drugs to sigma-1 receptors (Cobos et al., 2005, 2006 and 2007). After finishing my PhD studies, I continued my research activities in the group of Prof. Baeyens, studying the involvement of sigma-1 receptors in pain. We found that sigma-1 receptors appear to be a promising new target for the treatment of mechanical allodynia (pain induced by normally innocuous stimulation) (Entrena et al., 2009a and b).

I joined Prof. Clifford Woolf’s lab in May 2009 as a postdoctoral fellow. My current research interests focus on: (i) identifying genes of interest that play a major role in the development of neuropathic pain (together with Dr. Michael Costigan); (ii) studying the involvement of heat shock protein (Hsp) 27 (together with Dr. Eddie Ma) and the transcription factor ATF-3 (together with Dr. Rhona Seijffers) in functional recovery after peripheral nerve injury; and (iii) developing new behavioral phenotyping tools for the study of chronic (inflammatory and neuropathic) pain and functional recovery after peripheral nerve injury.

Publications
Contreras-Jurado C, González-Martínez MT, Cobos EJ and Soler Díaz A. Fluorometric evidence for different stoichiometries for the Na+/Mg2+ exchange in Mg-loaded thymocytes. Front Biosci. 2004; 9:1843-8.

Cobos EJ, Baeyens JM and Del Pozo E. Phenytoin differentially modulates the affinity of agonist and antagonist ligands for σ1 receptors of guinea pig brain. Synapse. 2005; 55(3):192-5.

Cobos EJ, Lucena G, Baeyens JM and Del Pozo E. Differences in the allosteric modulation by phenytoin of the binding properties of the σ1 ligands [3H](+) pentazocine and [3H]NE-100. Synapse. 2006; 59(3):152-161.

Cobos EJ, Del Pozo E and Baeyens JM. Irreversible blockade of sigma-1 receptors by haloperidol and its metabolites in guinea pig brain and SH-SY5Y human neuroblastoma cells. J. Neurochem. 2007; 102: 812-825.

Entrena JM, Cobos EJ, Nieto FR, Cendán CM, Baeyens JM and Del Pozo E. Antagonism by haloperidol and its metabolites of mechanical hypersensitivity induced by intraplantar capsaicin in mice: role of sigma-1 receptors. Psychopharmacol. 2009; 205(1):21-33.

Entrena JM*, Cobos EJ*, Nieto FR, Cendán CM, Gris G, Del Pozo E, Zamanillo D and Baeyens JM. Sigma-1 receptors are essential for capsaicin-induced mechanical hypersensitivity: studies with selective sigma-1 ligands and sigma-1 knockout mice. Pain 2009; 143(3):252-261. [*contributed equally to this work].

Patents
Nieto FR, Baeyens JM, García-Granados A, Entrena JM, Cobos EJ, Martínez-Rodríguez A, Parra-Sánchez, A and Rivas-Sánchez F. Use of maslinic acid for the treatment of pain from nociceptive, inflammatory or neurogenic origin. Publication number: ES 2 333 638 (Spain, 2010).

Reviews
Ocaña M, Cendán CM, Cobos EJ, Entrena JM and Baeyens JM. Potassium channels and pain: present realities and future opportunities. Eur J Pharmacol. 2004; 500(1-3):203-19.

Cobos EJ, Entrena JM, Nieto FR, Cendan CM and Del Pozo E. Pharmacology and Therapeutic Potential of Sigma-1 Receptor Ligands. Curr. Neuropharmacol. 2008; 6(4): 344-366.

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