The Woolf Laboratory

LIke ThisLIke ThisLIke ThisLIke ThisLIke This

Boston Children's Hospital
300 Longwood Avenue
CLS 12260
Boston, MA 02115

Neural Plasticity Research Group

This group is devoted to investigating the way in which functional, chemical and structural plasticity of neurons contributes to adaptive and maladaptive function of the mammalian nervous system. Our major efforts are devoted to the study of pain, the formation of neural circuits during development, and failure of regeneration of the adult CNS. Most of our work is concentrated on primary sensory and spinal cord neurons using a multidisciplinary approach spanning, molecular and cell biology, bioinformatics, synaptic electrophysiology, neuroanatomy, integrative systems biology and behavior. The group works closely with a wide number of academic groups and the pharmaceutical and biotechnology industry to identify and validate molecular targets for novel analgesics and axonal growth determinants.

Some of the major research interests of the group include:

  • The role of the DRAGON/RGM family of membrane associated proteins.
  • Role of tetrahydrobiopterin in pain.
  • Neuro-immune interactions.
  • Post-translational processing and transcriptional control of membrane receptors and ion channels mediating pain hypersensitivity.
  • Intracellular signal transduction cascade and transcription factor activation in neurons.
  • Mechanisms responsible for cell survival in injured sensory and motor neurons.
  • Relative contributions of intrinsic growth determinants and extrinsic growth inhibitors in establishing regenerative capacity in the central nervous system.
  • Role of cell death in producing neuropathic pain.
  • Central sensitization, it's mechanism and contribution to pain.
  • Clinical trials to establish the mechanisms responsible for producing pain.
Request an Appointment

If this is a medical emergency, please dial 9-1-1. This form should not be used in an emergency.

Patient Information
Date of Birth:
Contact Information
Appointment Details
Send RequestIf you do not see the specialty you are looking for, please call us at: 617-355-6000.International visitors should call International Health Services at +1-617-355-5209.
Please complete all required fields

This department is currently not accepting appointment requests online. Please call us at: 617-355-6000. International +1-617-355-6000.

This department is currently not accepting appointment requests online. Please call us at: 617-355-6000. International +1-617-355-6000.

Thank you.

Your request has been successfully submitted

You will be contacted within 1 business day.

If you have questions or would like more information, please call:

617-355-6000 +1-617-355-6000
Find a Doctor
Search by Clinician's Last Name or Specialty:
Select by Location:
Search by First Letter of Clinician's Last Name: *ABCDEFGHIJKLMNOPQRSTUVWXYZ
Condition & Treatments
Search for a Condition or Treatment:
View allSearch
The future of pediatrics will be forged by thinking differently, breaking paradigms and joining together in a shared vision of tackling the toughest challenges before us.”
- Sandra L. Fenwick, President and CEO