We are a cell biology and bioengineering laboratory within the Department of Cardiac Surgery at Boston Children's Hospital. We are affiliated with the Harvard Medical School. We specialize in the biology and therapeutic potential of human Endothelial Colony-Forming Cells.
Stem cell transplantation and tissue engineering hold great promise in Regenerative Medicine. However, generating tissues with stable functional vascular beds remains a major challenge. Our laboratory is interested in understanding mechanisms of vascular network formation using human stem and progenitor cells. Current projects in the lab are focused on:
- Endothelial colony-forming cells (ECFCs)
- Bioengineering vascular networks
- Genetically-engineered vasculature for protein drug delivery
Adventures in gene therapy: Getting your own blood vessels to make drugs
June 18, 2014. Juan Melero-Martin, VECTOR blog
Human endothelial colony-forming cells serve as trophic mediators for mesenchymal stem cell engraftment via paracrine signaling. Lin RZ, Moreno-Luna R, Li D, Jaminet SCS, Greene AK, Melero-Martin JM. Proc Natl Acad Sci USA 2014; 111(28):10137-10142. PDF
Decreased level of cord blood circulating endothelial colony-forming cells in preeclampsia. Muñoz-Hernandez R, Miranda ML, Stiefel P, Lin RZ, Praena-Fernandez JM, Dominguez-Simeon MJ, Villar J, Moreno-Luna R, Melero-Martin JM. Hypertension 2014; 64(1):165-171. PDF
Transdermal regulation of vascular network bioengineering using a photopolymerizable methacrylated gelatin hydrogel. Lin RZ, Chen YC, Moreno-Luna R, Khademhosseini A, Melero-Martin JM. Biomaterials 2013; 34(28):6785-96. PDF
Induction of erythropoiesis using human vascular networks genetically-engineered for controlled erythropoietin release. Lin RZ, Dreyzin A, Aamodt K, Li D, Jaminet SC, Dudley AC, Melero-Martin JM. Blood 2011; 118(20):5420-8. PDF
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HSCI/Children's researcher wins prestigious Bayer Hemophilia Award
May 19, 2014. Harvard Stem Cell Institute (HSCI)