Research by Benjamin Matthews

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Microfluidic Cell Videos

Rapid Air into Liquid

DIC timelapse liquid into air

Cell initially compressed while in air, reexpands once liquid passes over

936 Kb, 0:07 min

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DIC Videos Air and Liquid

DIC timelapse air into liquid then trapped liquid

DIC timelapse air into liquid then trapped liquid

 
47.7 Mb, 0:20 min

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trapped liquid pushing into air

trapped liquid pushing into air

48.4 Mb, 0:20 min

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DIC air into liquid at 25 ul per min

DIC air into liquid at 25 ul per min

 
5.06 Mb, 0:02 min

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Phase Air into Liquid

Phase contrast timelapse images of air bubble passing over airway epithelial cells cultured on fibronectin coated coverslip inside microfluidic device

Phase contrast timelapse of airway epithelial cells cultured on the bottom of a fibronectin coated microfluidic device (500 um x X um) and exposed to a semi-infinite bubble travelling at a speed of 5 ul per minute. Note that pressures were not transduced. As air passes over the cells (traveling from bottom to top of image), the entire cytoplasm and nucleus are uniformly compressed, which causes the cell cytoplasm to be immediately (within 100 ms) expelled into newly formed blebs.

Phase contrast timelapse of air into liquid at 5 ul per minute

Air into liquid results in cell compression and blebbing

23.5 Mb, 0:08 min

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Phase contrast timelapse showing the sequential effect of the force gradient generated by the moving air bubble (black shadow) on the cells. Cells at the bottom respond earlier than cells in the middle of the image, which in turn respond earlier than cells at the top of the image.

Air into liquid high speed lower resolution

Air into liquid high speed lower resolution

10.2b Mb, 0:12 min

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