Christopher Walsh MD PhD

LIke ThisLIke ThisLIke ThisLIke ThisLIke This

Christopher Walsh, MD, PhD

Christopher Walsh, MD, PhD, is widely regarded as one of the nation's leading neurogeneticists. His research is illuminating both the causes of devastating developmental disorders, such as mental retardation and autism, and providing insight into the normal growth and functioning of the human brain. Among his laboratory's research interests is microcephaly, a condition in which the brain fails to achieve normal growth, resulting in mental retardation (MR) and other serious problems. Treatment is symptomatic and supportive; there is no treatment for the underlying condition.

The genes responsible for microcephaly are often essential for proliferation of the stem cells that give rise to neurons in the brain. Thus identification of genes that cause microcephaly will lead not only to better diagnosis and counseling for families with affected children, but also to a better understanding of human brain stem cells, which may have important relevance for developing stem cell therapies.

Dr. Walsh's laboratory has identified more than 2,000 families with different forms of MR from around the world and has found genes associated with microcephaly and similar disorders. Among the half-dozen genes associated with microcephaly are some that are also linked with an elevated risk of developing cancer and immune system disorders.

Once an MR gene is identified, it is vital to develop clinical DNA tests and prenatal screening methodologies, which make it possible for physicians to offer better genetic counseling for families. In addition to their gene-finding studies, Dr. Walsh and colleagues carry out painstaking studies to understand the basic biological functions of the genes they have identified, with the aim of applying this knowledge in the development of new therapies for troubling disorders.

A Howard Hughes Institute Investigator, Dr. Walsh has received many awards, including the Research Award from the American Epilepsy Society, the Dreifuss Penry Award from the American Academy of Neurology and the Derek Denny-Brown and Jacoby Awards from the American Neurological Association.

To learn more about the science behind Dr. Walsh's work, go to the Children's interactive feature The Neuron
Request an Appointment

If this is a medical emergency, please dial 9-1-1. This form should not be used in an emergency.

Patient Information
Date of Birth:
Contact Information
Appointment Details
Send RequestIf you do not see the specialty you are looking for, please call us at: 617-355-6000.International visitors should call International Health Services at +1-617-355-5209.
Please complete all required fields

This department is currently not accepting appointment requests online. Please call us at: 617-355-6000. International +1-617-355-6000.

This department is currently not accepting appointment requests online. Please call us at: 617-355-6000. International +1-617-355-6000.

Thank you.

Your request has been successfully submitted

You will be contacted within 1 business day.

If you have questions or would like more information, please call:

617-355-6000 +1-617-355-6000
Find a Doctor
Search by Clinician's Last Name or Specialty:
Select by Location:
Search by First Letter of Clinician's Last Name: *ABCDEFGHIJKLMNOPQRSTUVWXYZ
Condition & Treatments
Search for a Condition or Treatment:
View allSearch
The future of pediatrics will be forged by thinking differently, breaking paradigms and joining together in a shared vision of tackling the toughest challenges before us.”
- Sandra L. Fenwick, President and CEO