Mesenchymal Stem Cells and Osteogenesis

LIke ThisLIke ThisLIke ThisLIke ThisLIke This

Mesenchymal Stem Cells and Osteogenesis

Osteogenesis is a fundamental bone-forming process that is central to normal skeletal growth and development, skeletal responses to injury (fracture), and pathology resulting from inflammation, ischemia, metabolic/hormonal imbalance, cancer, aging, and genetic abnormalities. Orthopaedic surgical and pharmacologic intervention is often aimed at improving the rate and extent of vascularization and osteogenesis. Osteogenesis requires a healthy population of osteoprogenitor cells that are responsive to molecular cues and able to proliferate and differentiate into bone-forming osteoblasts.

We hypothesize that the mesenchymal stem cell pool of potential osteoprogenitor cells is resident in the microvasculature of all bone tissue, and is not necessarily confined to red bone marrow and rare circulating stem cells. Medicine currently lacks the critical knowledge of how to control and stimulate this pool of precursor cells in order to improve bone healing and skeletal integrity. Osteoprogenitor cells are poorly understood but have obvious applications in skeletal repair and corrective surgery. We have recently initiated a study of the vascular pericyte, because this cell has properties of a multipotent mesenchymal stem cell, including the potential for normal osteogenesis, osteogenic wound/fracture healing, and pathological vascular calcification.

Request an Appointment

If this is a medical emergency, please dial 9-1-1. This form should not be used in an emergency.

Patient Information
Date of Birth:
Contact Information
Appointment Details
Send RequestIf you do not see the specialty you are looking for, please call us at: 617-355-6000.International visitors should call International Health Services at +1-617-355-5209.
Please complete all required fields

This department is currently not accepting appointment requests online. Please call us at: 617-355-6000. International +1-617-355-6000.

This department is currently not accepting appointment requests online. Please call us at: 617-355-6000. International +1-617-355-6000.

Thank you.

Your request has been successfully submitted

You will be contacted within 1 business day.

If you have questions or would like more information, please call:

617-355-6000 +1-617-355-6000
Find a Doctor
Search by Clinician's Last Name or Specialty:
Select by Location:
Search by First Letter of Clinician's Last Name: *ABCDEFGHIJKLMNOPQRSTUVWXYZ
Condition & Treatments
Search for a Condition or Treatment:
View allSearch
The future of pediatrics will be forged by thinking differently, breaking paradigms and joining together in a shared vision of tackling the toughest challenges before us.”
- Sandra L. Fenwick, President and CEO