Obesity

LIke ThisLIke ThisLIke ThisLIke ThisLIke This

Fat, or adipose tissue, is one of the few tissues in the body that can grow and regress throughout life. To researchers in the Folkman lab, it seemed likely that angiogenesis had to be taking place as body fat increased, and that the new fat cells would die if angiogenesis were inhibited.

To test this hypothesis, Maria Rupnick, MD, PhD, and colleagues gave angiogenesis inhibitors to a strain of severely obese mice and to mice of normal weight. The new blood vessels in obese mice regressed and, in the process, fat cells died. As a result, the obese mice shed a significant percentage of their weight while on the angiogenesis inhibitors, but they regained it when the drugs were stopped. The angiogenesis inhibitors had little effect on the normal mice.

Rupnick's research established for the first time that the growth of at least one type of healthy tissue is controlled by angiogenesis. And, although preliminary, it may suggest a new approach to combating obesity. 

Request an Appointment

If this is a medical emergency, please dial 9-1-1. This form should not be used in an emergency.

Patient Information
Date of Birth:
Contact Information
Appointment Details
Send RequestIf you do not see the specialty you are looking for, please call us at: 617-355-6000.International visitors should call International Health Services at +1-617-355-5209.
Please complete all required fields

This department is currently not accepting appointment requests online. Please call us at: 617-355-6000. International +1-617-355-6000.

This department is currently not accepting appointment requests online. Please call us at: 617-355-6000. International +1-617-355-6000.

Thank you.

Your request has been successfully submitted

You will be contacted within 1 business day.

If you have questions or would like more information, please call:

617-355-6000 +1-617-355-6000
close
Find a Doctor
Search by Clinician's Last Name or Specialty:
Select by Location:
Search by First Letter of Clinician's Last Name: *ABCDEFGHIJKLMNOPQRSTUVWXYZ
BrowseSearch
Condition & Treatments
Search for a Condition or Treatment:
Show Items Starting With: *ABCDEFGHIJKLMNOPQRSTUVWXYZ
View allSearch
Locations
The future of pediatrics will be forged by thinking differently, breaking paradigms and joining together in a shared vision of tackling the toughest challenges before us.”
- Sandra L. Fenwick, President and CEO
Close