Marcus Gunn syndrome

LIke ThisLIke ThisLIke ThisLIke ThisLIke This

Marcus Gunn Jaw Winking Syndrome consists of elevation or depression of the eyelid on chewing/suckling and may occur either in one or both eyes, with or without congenital ptosis. It is hypothesized that axons, intended to travel within the motor branch of the trigeminal nerve (Cranial Nerve V) to innervate the ipsilateral pterygoid muscle, aberrantly (deviating from the normal course) innervate myofibers of the Levator Palpebrae Superioris (LPS)-the muscle that elevates and retracts the upper eyelid, which is normally innervated by a branch of Cranial Nerve III.

Individual with CFEOM1 and Marcus Gunn Syndrome-he controls his left eye position using his mouth position.

Marcus Gunn Jaw Winking Syndrome can occur in association with complex strabismus conditions such as Duane syndrome and CFEOM1,2. The boy to the right has bilateral congenital ptosis, upgaze limitation and, prior to extrocular muscle surgery, exhibited the Marcus Gunn phenomenon.

The majority of cases of this disorder are reported to be sporadic (isolated), although there are a few reports in the scientific literature of familial Marcus Gunn syndrome3

Please contact Caroline Andrews to obtain further information on the genetic studies that we are undertaking and if you are interested in enrolling a patient or participating yourself.

References

Online Mendelian Inheritance in Man (OMIM). Victor A. McKusick, Editor, Johns Hopkins University, last updated 11/6/1994 (entry number #154600) Home page: http://www3.ncbi.nlm.nih.gov/Omim/.

  1. Brodsky, M. Hereditary external ophthalmoplegia synergistic divergence, jaw winking, and oculocutaneous hypopigmentation: a congenital fibrosis syndrome caused by deficient innervation to extraocular muscles. Ophthalmology 105, 717-725 (1998).
  2. Abeloos, M.-C. et al. Fibrose Congenitale des muscles oculaires: un diagnostic pour plusieurs tableaux cliniques. Bull Soc Belge Ophtalmol 239, 61-74 (1990).
  3. Kirkham, T. H. Familial Marcus Gunn phenomenon. Brit. J. Ophthal. 53: 282-283, 1969.

Request an Appointment

If this is a medical emergency, please dial 9-1-1. This form should not be used in an emergency.

Patient Information
Date of Birth:
Contact Information
Appointment Details
Send RequestIf you do not see the specialty you are looking for, please call us at: 617-355-6000.International visitors should call International Health Services at +1-617-355-5209.
Please complete all required fields

This department is currently not accepting appointment requests online. Please call us at: 617-355-6000. International +1-617-355-6000.

This department is currently not accepting appointment requests online. Please call us at: 617-355-6000. International +1-617-355-6000.

Thank you.

Your request has been successfully submitted

You will be contacted within 1 business day.

If you have questions or would like more information, please call:

617-355-6000 +1-617-355-6000
close
Find a Doctor
Search by Clinician's Last Name or Specialty:
Select by Location:
Search by First Letter of Clinician's Last Name: *ABCDEFGHIJKLMNOPQRSTUVWXYZ
BrowseSearch
Condition & Treatments
Search for a Condition or Treatment:
Show Items Starting With: *ABCDEFGHIJKLMNOPQRSTUVWXYZ
View allSearch
Locations
The future of pediatrics will be forged by thinking differently, breaking paradigms and joining together in a shared vision of tackling the toughest challenges before us.”
- Sandra L. Fenwick, President and CEO
Close