Infectious Diseases Research Center

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Research in the Division of Infectious Diseases includes both basic investigation and clinical research. The bench research in the division has the broad objective of elucidating basic mechanisms of microbial pathogenesis and the related host responses that mediate susceptibility to infection, host injury, and protective immunity. Investigation targets viral, bacterial, fungal, and parasitic pathogens of major significance in community acquired infections in the United States, in infections of immunocompromised hosts, and in global public health. Current projects include:

  • Pathogen-host signaling in streptococcal infection
  • Novel strategies for pneumococcal vaccines
  • Enhancing innate and adaptive immunity in neonates
  • Regulation of bacterial virulence gene expression
  • Modeling cholera infection and host responses in Drosophila
  • HIV pathogenesis, immune response, and vaccine development
  • Regulation of morphogenesis in Candida albicans
  • Molecular approaches to malaria pathogenesis

Clinical research is focused in two broad areas: clinical trials in pediatric HIV and clinical epidemiology/clinical decision-making.

Researchers in the Division of Infectious Diseases hold faculty appointments at Harvard Medical School.

Latest Research in Infectious Diseases:


Asim A. Ahmed
Molecular mechanisms of viral entry, Host determinants of viral entry, Mosquito-borne viruses, Encephalitis, Emerging viruses
Anna Aldovini, MD HIV biology
Sandra Burchett, MD, MS Viral infections
Simon Dove, PhD Transcription regulation
Jeffrey Dvorin, MD, PhD Malaria, Parasitology, Tropical Medicine
Elizabeth Egan, MD, PhD Host Determinants of Malaria Pathogenesis
Courtney Gidengil, MD, MPH Pediatric Health Services Research
Donald Goldmann, MD Bacterial Infection
Robert N. Husson, MD Molecular pathogenesis of mycobacterial infection
Julia R. Koehler, MD Infectious Diseases
Grace M. Lee, MD, MPH Vaccine policy, Infectious disease epidemiology
Katherine P. Lemon, MD, PhD Human Upper Respiratory Tract, Human Microbiome (nose, throat, and skin), Bacterial Interspecies Interactions
Ofer Levy, MD, PhD Innate immunity of the human newborn
Yingjie Lu, PhD vaccine development for infectious disease
Richard Malley, MD Pneumococcal pathogenesis and immunity, vaccine development
Kenneth McIntosh, MD HIV and viral infections
John N. Misasi, MD Emerging virus entry mechanisms and pathogenesis
Kristin Moffitt, MD Host bacterial pathogen interactions, Bacterial vaccine development
Mari Nakamura, MD, MPH Vaccine health services research, Health information technology
Gregory Priebe, MD
Gregory Priebe, MD
Gregory Priebe, MD
Pseudomonas aeruginosa infections

Thomas J. Sandora, MD, MPH Hospital epidemiology, Hand hygiene, Healthcare-Associated Infections, Infection Prevention & Hospital Epidemiology
Tanvi Sharma, MD Pediatric HIV, Immunocompromised infectious diseases
 Michael Silverman, MD, PhD Immunology, Microbiome, Autoimmunity, Mucosal Immunity, Diabetes, Immunocompromised Host
 Jorge Velarde, MD, PhD  Pediatric Infectious Diseases
Paula I. Watnick, MD, PhD Bacterial adhesion to surfaces; enteric pathogens
Michael R. Wessels, MD Streptococcus infection
 Fan Zhang, PhD  Vaccine Development; Immune Mechanism of Protection Against Human Pathogens
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The future of pediatrics will be forged by thinking differently, breaking paradigms and joining together in a shared vision of tackling the toughest challenges before us.”
- Sandra L. Fenwick, President and CEO