Innovation

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Startups & Products

Over the years, Boston Children's TIDO has developed relationships with pharmaceutical, biotechnology, medical device, drug discovery and diagnostic companies to develop and launch products based on Boston Children's intellectual property and biomedical innovations. Boston Children's TIDO also works with venture capital and angel investors, nonprofit organizations, disease foundations, government agencies and contract research organizations (CRO's) to establish collaborations and relationships at all stages of innovation and development (e.g. research and development, pre-clinical and clinical testing) to facilitate the translation of our world-class, cutting edge research into new therapies, drugs, vaccines, diagnostics and devices. 

Click here for selected videos, interviews, and articles about successful Boston Children's innovations and researchers that have made inroads toward, or have already resulted in breakthrough products or improved the quality of healthcare and patient outcomes.

Startup Companies

  1. Emulate
  2. Neuro'motion
  3. Quartet Medicine
  4. Etiometry
  5. Affinivax
  6. Act.md
  7. Wired Informatics
  8. Scholar Rock
  9. Claritas Genomics
  10. DecImmune
  11. Epidemico → Booz Allen Hamilton
  12. Rebiscan - Founded in 2009
  13. CoStim Pharmaceuticals → Novartis
  14. Premacure → Shire
  15. ModeRNA - Founded 2010
  16. Fate Therapeutics - Founded in 2007 - ARCH Venture Partners and Polaris Venture Partners
  17. InVivo Therapeutics - Went public in October 2010
  18. Plureon Corporation - Founded in 2002
  19. Hydra Biosciences - Founded in 2001 - Polaris Venture Partners, Abingworth, New Enterprise Associates, Lilly Ventures, BioVentures, Biogen IDEC New Ventures, Advanced Technology Ventures
  20. Sopherion Therapeutics, Inc. - Founded 2001 - TL Ventures
  21. Effective Pharmaceuticals, Inc. → Pipex Pharmaceuticals → Synthetic Biologics, Inc.
  22. Genica Pharmaceuticals Corporation → Athena Neurosciences, Inc. → Elan Corporation (ELN)
  23. NeoMorphics, Inc. → Advanced Tissue Sciences, Inc. (ATIS) → Smith & Nephew
  24. OraPharma, Inc. (OPHM) → Johnson & Johnson (JNJ)
  25. Syntonix Pharmaceuticals, Inc. → Biogen IDEC (BIIB)
  26. w3health, Inc.
  27. Correlagen, Inc → LabCorp

Licensed Products

Clinical Trials

Product

Company

Boston Children's Inventor

Clinical Phase

GEN-004 Baxter Stuart Orkin, MD Phase III
Omegaven (Parenteral Nutrition Associated Liver Disease) Fresenius Kabi Mark Puder, MD, PhD Phase II/III
dmPGE2 Fate Therapeutics Leonard Zon, MD Phase II
IgF-I Shire Lois Smith, MD, PhD Phase II
NeoSTX Grunenthal Maria Rupnick, MD, PhD Phase IIa
Neuro-Spinal Scaffold for spinal cord injury InVivo Therapeutics Yang Dong (Ted) Teng, MD, PhD and Joseph Vicanti, MD Phase I

On the Market

Product

Company

Boston Children's Inventor

Therapeutics
Alprolix Biogen IDEC Wayne Lencer, MD
Eloctate Biogen IDEC Wayne Lencer, MD
Pomalyst Celgene Robert D'Amato, MD, PhD
Revlimid Celgene Robert D'Amato, MD, PhD
Thalomid Celgene Robert D'Amato, MD, PhD
Memantine Merz
Forest Laboratories
Stuart Lipton, MD, PhD
Neumega (Interleukin 11) Pfizer David Williams, MD
Stephan Paul, MD
 Vonvendi  Baxalta  Stuart Orkin, MD
Diagnostics
Muscular dystrophy diagnostic Athena Diagnostics, Inc. Louis Kunkel, PhD
INF2 DNA Sequencing Test Athena Diagnostics, Inc. Elizabeth Brown, MD
Merge EchoIMS for pediatric echocardiograph Merge Healthcare Steve Colan, MD
Devices
Plagio Cradle Boston Brace Gary Rogers, MD
Surgical Sam, fully operable infant surgical team trainer The Chamberlain Group Peter Weinstock, MD, PhD
Tracking, Trajectory, Trigger (T3) Intensive Care Unit monitoring system Etiometry Peter Laussen, MD, and Melvin C. Almodovar, MD
Research Tools
QuikChange® Mutagenesis Kits Agilent Technologies Raif Geha, MD 
Dowain Wright, MD, PhD
Other
TeachMate365 educational platform to create, manage and deliver modified instructional content SpecialNeedsWare Howard Shane, PhD
Autismate365, a comprehensive, autism app, mobile platform SpecialNeedsWare Howard Shane, PhD
Patient Communication Board Vidatak, LLC John Costello, MD, MPH

Partners

Over the years, Boston Children's has developed relationships with pharmaceutical, biotechnology, medical device, drug discovery and diagnostic companies to develop and launch products based on Boston Children's innovations. Boston Children's also works with venture capital and angel investors, nonprofit organizations, disease foundations, government agencies and contract research organizations (CRO's) to establish collaborations and relationships at all stages of innovation and development (e.g. research and development, pre-clinical and clinical testing) to increase the translation of our world-class, cutting edge research into new therapies, drugs, vaccines, diagnostics and devices. Below is a listing of commercialization partners that have collaborated with Boston Children's.

Organization

PI

Description

Venture Capital Organizations
ARCH Venture Partners Leonard Zon Part of a team of investors who formed Fate Therapeutics, with Dr. Len Zon as a scientific founder, developing a new approach to stem cell medicine.
Polaris Ventures Leonard Zon Part of a team of investors who formed Fate Therapeutics, with Dr. Len Zon as a scientific founder, developing a new approach to stem cell medicine.
Companies started by VCs
Fate Therapeutics Leonard Zon Created in 2007 with Dr. Len Zon as a scientific founder, developing therapeutics to promote stem cell therapy.
Zafgen M. Judah Folkman The world's first biotechnology company focused on the treatment of obesity through the direct targeting of adipose vasculature to safely reduce the size of fat tissue.
Non-Profit Funding Sources
Center for Integration of Medicine and Innovative Technology (CIMIT) Funded multiple Boston Children's Hospital investigators for minimally invasive technologies.
Harvard Stem Cell Institute (HSCI) Boston Children's Stem Cell Program; Leonard Zon, Director; George Daley, Associate Director Led by its Executive Committee (including from Boston Children's Stem Cell program, Leonard Zon, Chair, and George Daley), the HSCI provides early stage seed grant funding, targeted disease program project grants, and research core facility support in the field of stem cell research; the HSCI supports the embryonic stem cell core facility at Boston Children's Hospital, serving Boston Children's Hospital and the Harvard community. To date, 15 Boston Children's Hospital researchers have received HSCI research grants.
Massachusetts Technology Transfer Center State funding and grants for selected Boston Children's Hospital technology development projects, professional conferences and host of the Massachusetts online technology postings site.
National Institute of Health (NIH)/Department of Defense (DoD)/Small Business Innovation Research (SBIR) program Joseph Madsen, Eugene Goldfield Provide funding for early stage and prototype development of novel biomedical devices.
PATH/Genocea Biosciences Richard Malley Funding to develop a pneumococcal vaccine.
Company Collaborators and Sponsors
Charles River Laboratories N/A Storage of Proteins and Cell Lines.
Fisher Clinical Services N/A Storage of Proteins and Cell Lines.
Idera Pharmaceuticals Ofer Levy Sponsored research in the area of toll like receptor agonists.
Infoscitex Corporation (IST) Joseph Madsen, Eugene Goldfield Collaboration with IST for the development of a number of medical device prototypes
Microfabrica Pedro del Nido Collaboration with Boston University and Microfabrica to develop miniature tools at the end of steerable needles for use in intracardiac surgery.
Optimum Technologies, Inc. Farhad Imam Several prototypes developed for Dr. Imam's transluminal catheter.
Philips Healthcare Pedro del Nido Collaboration with Harvard University, Boston University and Philips Healthcare to develop ultrasound imaging intracardiac beating heart surgery.
QinetiQ North America/Foster-Miller, Inc. (FMI) Joseph Madsen, Eugene Goldfield Collaboration with FMI for the development of a number of medical device prototypes
Symmetry Medical TNCO Pedro del Nido Worked to develop a prototype of a video-assisted cardioscopy port for beating heart intracardiac surgery.
Symmetry Medical TNCO Martha Murray Worked to develop a prototype for delivering a proprietary tissue repair material to the meniscus in the knee. The device was designed for minimally-invasive procedures to facilitate healing within the body.

Boston Children's Hospital has licensed to the following representative companies:

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