Do you know someone who has made extraordinary and sustained leadership contributions throughout their career to improve pediatric health care? Or, an innovator who solves problems in new ways to benefit patients? Recognize your peer before nomination close Aug. 31.
On Nov. 9 + 10, 2015, join clinicians, health care leaders, investors, engineers, biopharm and device companies, IT executives, policy professionals, venture capitalists, payers and other stakeholders as we partner to address unmet needs, solve problems and seize opportunities in pediatric health care. This year’s theme is precision pediatrics.
Disease-modifying autism treatments, preventing blinding eye diseases and genetic sickle-cell therapies: Three examples of NIH tax dollars at work.
Boosting migration of donor stem cells could make cord blood transplant more viable for cancer and blood disorders, helping patients find a match.
Magnetized robots, guided by the magnetic field of an MRI scanner, could swim through body fluids to drive needles, puncture tissues or deliver drugs.
Telomeres tip our chromosomes and keep them from degrading. A new study finds shortened telomeres in families with autism--now the question is why.
Deaf mice receiving gene therapy to provide a working TMC1 gene began to hear for the first time.
At the Boston Children’s Hospital Cardiovascular Research Center, researchers were able to effectively reverse the phenotype for cardiomyopathy by intervening early in the genetic coding process for the disease.
Computational epidemiologist John Brownstein talks about how "digital phenotypes" can open new windows into people's health.
Tests for detecting Ebola in the blood can take anywhere from 12 hours to four days to yield results. But a recent study published in The Lancet reveals a new test can accurately determine results in mere minutes.
A mouse study suggests that omega-3 fatty acids, like those found in fish oil, may reduce inflammation in sickle cell disease.
Non-narcotic treatments for chronic pain that work well in people, not just mice, are sorely needed. Drawing from human pain genetics, an international team demonstrates a way to break the cycle of pain hypersensitivity without the development of addiction, tolerance or side effects.
Observing mating behavior in male fruit flies is an easy way to observe motivation. Moreover, the brain circuitry behind fly mating has already been characterized, thanks to the creature’s very small brain.
According to research by Denisa Wagner, PhD, of Boston Children’s Hospital’s Program in Cellular and Molecular Medicine, a poorly understood feature of our immune system’s neutrophils may be one more ingredient in the storm.
While traditional global health programs have focused on curbing infectious disease, low-resource settings like Dhaka are also coming to be seen as “living laboratories” for investigating how adversity affects children’s brain development.
Ten mothers of children with neuromuscular disorders were interviewed about their diagnostic odyssey. The results highlight the distress that can be caused by even minor medical procedures and the benefits to the family of obtaining a diagnosis.
The care and feeding of more than 250,000 zebrafish just got better, thanks to a $4 million grant from the Massachusetts Life Sciences Center to upgrade Boston Children’s Hospital’s Karp Aquatics Facility. Aside from the fish, patients with cancer, blood diseases and more stand to benefit.
Research on cancer immunotherapy—treatments that spur an immune response against cancer cells—has boomed in recent years. And one of the more recent methods—called chimeric antigen receptor (CAR) T-cell therapy—is now in a clinical trial.
A recent study conducted by Boston Children’s Hospital urologist Carlos Estrada, MD and bioengineer Joshua Mauney, PhD, shows two-layer, biodegradable silk scaffolds to be a promising cell-free, “off-the-shelf” alternative to traditional implants for the reconstruction.
Researchers at Boston Children's have found a noninvasive alternative method to measure children’s intracranial pressure in the ear.
Edda Fiebiger, PhD, has been studying IgE and allergies for years, and has noticed a curious association in several epidemiologic studies: people with high levels of IgE in their blood (as in people with allergies) have a lower risk of certain cancers.
Some great inventions were on view at the second annual Boston Children’s Hospital Innovators Showcase. Hosted by the hospital’s Innovation Acceleration Program and Technology & Innovation Development Office, the event featured everything from virtual reality goggles with gesture control to biomedical technologies.
It’s long been known that a master clock in the hypothalamus, deep in the center of our brain, governs our bodily functions on a 24-hour cycle.
David Hunter, MD, PhD, chief of Ophthalmology at Boston Children’s Hospital, gets a lot of questions from parents, but the number one question is: “What can my baby see?”
Can sequencing of newborns’ genomes provide useful medical information beyond what current newborn screening already provides? What results are appropriate to report back to parents? What are the potential risks and harms? How should DNA sequencing information be integrated into patient care?
Children with Rett syndrome display distinctive hand movements or stereotypies, including hand wringing, clasping and other repetitive hand movements. With help from a grant from Boston Children’s Hospital’s Innovation Acceleration Program, researchers are transforming these hand movements into an assessment tool.
Boston Children’s Hospital received nearly $2.2 million from the Massachusetts Life Sciences Center (MLSC) to create a Human Neuron Core. The facility will allow researchers at Boston Children’s and beyond to study neurodevelopmental, psychiatric and neurological disorders directly in living, functioning neurons made from patients with these disorders.
Our genes can mutate at any point in our lives. In rare cases, a mutation randomly occurs in a single cell of an embryo and gets carried forward only in the descendants of that particular cell, leaving its mark in some tissues, but not in others. This pattern of mutation, called somatic mosaicsm, can have complicated consequences down the road.
Life teems with interactions. Proteins bind. Bonds form between atoms, and break. Enzymes cut. Drugs attach to cell receptors. DNA hybridizes. Those interactions make the processes of life work, and capturing them has led to many medical advances.
“This ground-breaking paper shows that with encapsulated, frozen donor stool, fecal transplantation can be used to successfully treat recurring C-diff infection in 90 percent of cases,” says George H. Russell, MD, MS, pediatric gastroenterologist in the Inflammatory Bowel Disease Center at Boston Children’s Hospital and co-author of the Massachusetts General Hospital-sponsored study.
As Epilepsy Awareness month closes out and we embark upon the holiday season, we’re pleased to see an innovation initiated here at Boston Children’s Hospital move toward commercial development.
Evolution is a strange thing: sometimes it favors keeping a mutation in the gene pool, even when a double dose of it is harmful—even fatal. Why? Because a single copy of that mutation is protective in certain situations.
A major theme at Taking on Tomorrow 2014 was the difficulty in making the business case for innovation in pediatrics, since the market size is small relative to the adult market. Muna AbdulRaqqaq Tahlak, MD, CEO of Latifa Hospital in Dubai, was among many who urged innovators to collaborate and aggregate their data to make the most impact.
An alternative method to measure intracranial pressure
BabySee: Mobile app lets you see through an infant’s eyes
Can rare disease genes be protective?
John Brownstein, PhD
Boston Children’s Hospital’s new chief innovation officer is an epidemiologist by training and a founding father of the growing field of digital epidemiology—the use of digital data from a variety of sources to detect and track disease and promote health.
Bruce Zetter, PhD
Though he has had a lifelong passion for science, he once toyed with an acting career. But he stuck with science and pursued a career in academic medicine. Countless patients, students, business partners and mentees have benefitted.
Michael J. Docktor, MD,
Boston Children’s Hospital’s clinical director of Innovation and director of Clinical Mobile Solutions, is also a practicing gastroenterologist, a proud father of two and a passionate mobile-and-digital health trailblazer.
Gena Koufos, RN, MS, MBA, is program manager in Boston Children’s Hospital’s Innovation Acceleration Program. Her role entails designing new programs to support innovation acceleration across the institution
David G. Hunter, MD, PhD, dreamed of a career as a rock star. Instead, he became Boston Children’s Hospital’s ophthalmologist-in-chief and invented the Pediatric Vision Scanner.
Martha Murray, MD has been on a 30-year quest to devise a better way to treat anterior cruciate ligament (ACL) tears.
With all of the recent buzz about precision medicine, it’s no wonder that William Pu, MD is gaining recognition for his innovative application of stem cell science and gene therapy to study Barth syndrome, a type of heart disease that severely weakens heart muscle. Pu’s research was recently recognized by the American Heart Association as one of the top ten cardiovascular disease research advances of 2014.
He’s a big thinker focused on harnessing the hyper-small. Daniel Kohane, MD, PhD, is a leading drug delivery and biomaterials researcher, leveraging nanoparticle technology and other new vehicles to make medications safer and more effective.
Improbable as it sounds, autism researcher Susan Faja, PhD, likens her job to improv. “I really like Tina Fey’s description of her days as an improv comedian,” says Faja, who joined ...
Beggs Laboratory: Current studies are aimed at identification of new nemaline myopathy genes, understanding the basis for the variability observed, and determining how these mutations affect muscle function and lead to weakness.
The Lencer Laboratory is located in the GI Cell and Developmental Biology Laboratories in the GI Division at Boston Children's Hospital.
Sports Medicine Research Laboratory
Led by principal investigator Dr. Martha M. Murray, focuses on sports medicine injuries, including those of the anterior cruciate ligament (ACL), knee meniscus and articular cartilage.
Utilizing rare and common human genetic variation to improve our understanding of red blood cell production and globin gene regulation with application to numerous blood diseases.
The Zon Laboratory focuses on the use of the zebrafish model for research into hematopoiesis and as a screen for oncogenic genes and proteins.
The Boston Globe
Boston Business Journal
MIT Technology Review
PBS News Hour
New York Times
Boston Children's Hospital exhibit brings big technologies, promising platforms to forefront
Healthcare IT News
Vector - Boston Children's Hospital's science and clinical innovation blog
International health initiative combines clinical expertise with cloud-based social networking technologies to build pediatric medical skills
U.S.News & World Report
By Naomi Fried, PhD
Your viral history in a drop of blood: http://t.co/941L7aWL0d via @harvardmed @haleybridger
Pregnancy: Prepare for unexpected prenatal test results. http://t.co/BbDDESrYlg via @NatureNews @DianaBianchiMD
Mosaic mutations may be more common than we thought: http://t.co/ObEZE1XS0M via @TheScientistLLC #genetics #genomics http://t.co/U0ById9uXB
Deadline extended to June 25: Join CLARITY Undiagnosed to find answers for families. http://t.co/fDXSJER0lv cc @harvardmed #CLARITYChallenge
The future of #precisionmedicine: Register today for the Boston Children's Global Pediatric Innovation Summit. http://t.co/nD67yERlWS
Make #genomics history: Deadline is June 25 to apply to #undiagnosed disease challenge. http://t.co/KbVnPKYuCz cc @harvardmed
Applications close June 25: Crowd-sourcing the medical mysteries of the #undiagnosed: http://t.co/YfNiA5DQS3 cc @CatBrownstein
Neuroenhancement is a constant. History infers future brain possibilities are endless: http://t.co/rdaD3BPtxJ via @TheAtlantic @mkonnikova
How many viruses have invaded your body during your life? Now you can know: http://t.co/sOeIRjg6sm via @washingtonpost @brady_dennis
Fruit flies + #optogenetics may lift the veil of mystery on motivation: http://t.co/s1KvbkLmEe http://t.co/fF9LyoP235
Fly mating behavior could clarify brain cells' role in motivation: http://t.co/1xCzkbju7o #neuroscience
Are you on target for #PedInno15? Take advantage of our 20% off early bird pricing by 6/30: http://t.co/5MgL7w3z8F #precisionmedicine