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Pressroom:
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EMBARGOED FOR RELEASE:
Monday, February 3, 2003, 5 p.m. ET
For Further Information:
Susan Craig
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New Way of Analyzing Hospital Visit Data Improves Ability to Detect Bioterrorist Attacks
Approach Could Help To Quickly & Reliably Identify Outbreaks and Speed Up Response
A team of scientists at Children's Hospital Boston presents a new way to detect bioterrorist attacks by analyzing hospital visit data over time. The researchers suggest that a system built with multiple filters, each looking for a different type of outbreak over a period of days, could achieve dramatic improvements in both the timeliness and reliability of detection, in some cases more than doubling the performance of current systems. The findings have a potentially wide impact on improving the surveillance systems that are currently being built around the country on the local, state and national levels. The article, "Using Temporal Context to Improve Biosurveillance," will be published in the Proceedings of the National Academy of Science Online Early Edition (#5026) the week of Feb. 3-7, 2003.

"Due to the immediate need for treatment after a bioterrorist attack, knowing early is often as important as knowing at all," says Reis. "These systematic improvements to our detection abilities could help enable a more timely and effective response."

Currently, disease-monitoring agencies attempt to detect outbreaks by comparing daily hospital visit rates with a historic model-generated forecast for each day. A suspicious increase in the daily visit rate over the predicted forecast for the day could be the first sign of a covert bioterrorist attack. However, this single-day approach can fail due to the unpredictable nature of normal disease patterns.

To combat this problem, Ben Y. Reis, Ph.D., first author of the paper who performed this research while he was in the Children's Hospital Informatics Program, and colleagues developed a system that uses multiple ''filters'' to analyze visit rates over a continuously shifting seven-day period. To address the fact that outbreaks can affect hospital visit rates in different ways, the researchers developed four different filters to look for different patterns: a fixed increase in visits over seven days; a week-long, steady increase; a week-long, exponential increase; and a simple one-day increase, typical of current systems.

After testing this multiple-filter approach on 10 years of hospital visit data spiked with simulated bioterror attacks, the researchers found that each of the weeklong filters worked better than the one-day approach. Researchers also found the weeklong filters detected disease outbreaks even better when working simultaneously. The researchers suggest that the detection capabilities of a multiple moving filter system could help enable a timely and effective response in the event of a deadly bioterrorist attack.

Kenneth D. Mandl, research director in the Division of Emergency Medicine, at Children's Hospital Boston and faculty member at the Children's Hospital Informatics Program, is senior author of this paper. Marcello Pagano, Ph.D., is second author. Reis is now at the Markle Foundation in New York, N.Y.

Children's Hospital Boston is home to the world's largest research enterprise based at a pediatric medical center, where its discoveries have benefited both children and adults for over 100 years. More than 500 scientists, including seven members of the National Academy of Sciences, nine members of the Institute of Medicine and nine members of the Howard Hughes Medical Institute comprise Children's research community. Founded in 1869 as a 20-bed hospital for children, Children's Hospital Boston today is a 300-bed comprehensive center for pediatric and adolescent health care grounded in the values of excellence in patient care and sensitivity to the complex needs and diversity of children and families. It is also the primary pediatric teaching affiliate of Harvard Medical School. For more information about the hospital visit: www.childrenshospital.org.

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Editor's Note: A graphic describing the four different filters that simultaneously analyze hospital visit data in search of a bioterrorist attack is available by request.

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