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Press Room
FOR IMMEDIATE RELEASE
Monday, December 6, 2004, 5 a.m. EST
Press Availability: Noon on Monday, Dec. 6
For Further Information:
Susan Craig
617-355-6420
susan.craig@childrens.harvard.edu
Children's Hospital Boston Surgeons Perform First Multivisceral (quadruple-organ) Transplant in New England
Infant receives New Liver, Pancreas, Intestine and Stomach at 8 months old
Now Healthy Infant Celebrates First Birthday, Heads Home from Hospital
Eleven-month-old Abdullah Alazemi of Kuwait may be from a foreign country, but ''firsts'' are not foreign to him. Alazemi is New England's first recipient of a multivisceral transplant, an operation in which the stomach, pancreas, liver and small intestine are transplanted, and he will celebrate his first birthday Sunday, Dec. 12. After an early birthday celebration on Monday, Dec. 6, Alazemi will be discharged from Children's Hospital Boston.

Alazemi was born with severe Hirschsprung's disease, a condition in which a lack of nerve cells in the intestine prevent it from receiving signals from the brain to move food forward in the intestinal tract. This can cause obstruction or blockage, an inability to tolerate feeding and ultimately liver failure, which can lead to a need for transplantation of organs for survival.

Alazemi, who was born in Kuwait on Dec. 12, 2003, was diagnosed with long segment Hirschsprung's disease involving nearly all of the small and large intestine shortly after birth. He became very sick very quickly. It was determined he would need an intestinal transplant in order for him to live. Officials in his country determined he should come to Boston for surgery and agreed to assist with medical costs and living expenses.

The Alazemi family arrived in Boston last February with Abdullah only weighing 4 kilos (8.8 lbs.). The Short Bowel Program, run by Drs. Tom Jaksic and Christopher Duggan, treated Abdullah so that he would gain weight and be healthy enough to undergo the transplant. He was placed on the transplant waiting list in April in hopes that small enough organs would become available before he got sicker.

On Aug. 31, Dr. Heung Bae Kim, the Surgical Director of the newly formed Liver, Intestine & Multivisceral Transplantation Center at Children's Hospital Boston, got an early morning phone call that a set of organs had become available. Kim rushed to the hospital where the donor was to procure the stomach, pancreas, liver and small intestines. At the same time, Children's Transplant Surgeon Jaksic and Roger Jenkins, Chief of Surgery at the Lahey Clinic, prepared Abdullah for his surgery.
In a six-hour, complicated procedure, the surgical team lead by Kim, carefully removed Abdullah's abdominal organs and replaced them with a donor's non-diseased stomach, pancreas, liver and small intestine. Anesthesiologists Drs. Laura B. Myers and Norichika Okada worked diligently to keep Abdullah alive during the difficult procedure, allowing the surgical team to complete the delicate operation. All went very well and the operation took less time than expected.

''The organs are really treated as one,'' says Dr. Kim. ''All the organs are kept connected and transplanted all at once. In this case, the patient needed the intestine and the liver. The stomach and pancreas came along for the ride. Since the baby is so small, it is easier to leave the organs together for transplant.''

Surgeons need only to connect one artery (the aorta - the body's main artery) and one vein when reattaching the organs into the patient, as opposed to all the blood vessels that would be involved with each organ separately.

''We were pleasantly surprised with how well he did after the operation,'' says Kim. ''He spent eight days in the Intensive Care Unit and has been in the hospital for three months. Now he's ready to go home.''

Despite a bout with an infection and having to take medication to fight graft-versus-host disease, a condition in which the donor organs reject the host, Abdullah has done very well after his complicated surgery. He will stay in the area for the next several months until his parents feel comfortable with the ongoing care they will need to provide for him, and until Children's doctors give the nod that he is healthy enough to head back to Kuwait.

Abdullah's parents, Ahmed and Reem, are thrilled to see their son doing so well, especially after he came to the U.S. as such a sick infant. Alazemi took leave from his job with the Kuwaiti Ministry of the Interior, where he is employed controlling the border between Kuwait and Iraq, to come to the U.S.

''What makes this hospital great and distinguished is the people here that helped Abdullah everywhere he went throughout the hospital,'' said Alazemi through an interpreter. When the family left Kuwait, his father said he was tiny, and they were afraid of losing him, like they had lost his older brother, who also had long segment Hirschsprung's disease, at the age of 6 months, six years ago. Although they had to make many sacrifices to leave their home country for treatment, Ahmed says, ''We didn't hesitate. If Abdullah had a chance somewhere, we had to make sure he would have that chance.''

The Alazemi's brought their 4-year-old daughter, Fatma, to the U.S. with them. They left their other two daughters, Afrah, 12, and Rwan, 9, with their paternal grandmother and aunt in Kuwait.

This operation was a first for Children's Hospital Boston and a first for their team of surgeons. Multivisceral transplants began in 1987 and the procedure slowly grew in popularity throughout the 1990s. The University of Pittsburgh, the University of Miami, and the University of Nebraska are the three major centers with the most experience performing this operation. The Children's team visited the University of Miami and the University of Pittsburgh to learn the operation before starting the New England program this past summer.

For more information about the center, call (888) CH-LIVER or (888) 245-4837 or locally (617) 35-LIVER (617-355-4837). For more information about Hirschsprung's disease and its treatment, visit: www.childrenshospital.org. To learn more about organ donation, call the New England Organ Bank at (800) 446-NEOB.

Children's Hospital Boston is the nation's leading pediatric medical center, the largest provider of health care to Massachusetts' children, and the primary pediatric teaching hospital of Harvard Medical School. In addition to 325 inpatient beds and comprehensive outpatient programs, Children's houses the world's largest research enterprise based at a pediatric medical center. More than 500 scientists, including eight members of the National Academy of Sciences, nine members of the Institute of Medicine and 10 members of the Howard Hughes Medical Institute comprise Children's research community.

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