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Boston Children's Hospital presents Vijay G. Sankaran, MD, PhD, with Rising Star Award at Global Pediatric Innovation Summit

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Recognized for innovative, all-inclusive view of the science and future treatment of red blood cell disorders


BOSTON (November 11, 2015) – Saluting his spectacular track record to date of innovative research on red blood cell disorders and his future promise as a physician/scientist, Boston Children's Hospital has selected Vijay G. Sankaran, MD, PhD, of Dana-Farber/Boston Children's Cancer and Blood Disorders Center to receive the Rising Star Award at the hospital's third annual Global Pediatric Innovation Summit, Taking on Tomorrow (#PedInno15).

The Rising Star Award recognizes the outstanding achievements of an up-and-coming innovator or team of innovators under the age of 45 in the field of pediatric health care. The award recipient receives $25,000 to be used to advance the work for which they are recognized. The presentation of the Rising Star Award and companion Lifetime Impact Award in a ceremony at the Seaport World Trade Center on November 10 marked the culmination of a two-day summit that brought together innovators and thought leaders from across the globe to examine clinical, informatics and business opportunities in pediatric innovation.

"Vijay's work exemplifies why the Rising Star was created—he's a shining example of the fact that the best in pediatric innovation is yet to come," said Boston Children's Hospital President and CEO Sandra L. Fenwick. "What makes his work with blood stem cells so significant isn't the impact that it could have on children at Boston Children's Hospital; it's the impact it could have on patients of all ages, worldwide."

Sankaran has risen remarkably quickly to become one of today's leading young scientists in hematology and oncology. He received his doctorate and medical degree from Harvard Medical School in 2009 and 2010, respectively, followed by simultaneous medical and postdoctoral research training at Boston Children's Hospital, Boston Medical Center, the Whitehead Institute for Biomedical Research and the Broad Institute. A board-certified pediatric hematologist/oncologist, Sankaran both established his laboratory at Dana-Farber/Boston Children's and was appointed an assistant professor of pediatrics at Harvard Medical School in January 2014.

"Vijay is extremely unusual for a scientist at his career stage in that he can both conceptualize an entire field of investigation and define a focused set of studies that get to the heart of a difficult problem," the Whitehead Institute's Harvey Lodish, PhD, one of Sankaran's mentors, wrote seconding him for the award. "He is a physician-scientist who is expert in fields as diverse as human genetics and computational analysis of genetic and molecular data; he is also a skilled diagnostician and is already considered a world expert in hematologic diseases."

Starting with his work with Lodish and mentors Stuart H. Orkin, MD, of Dana-Farber/Boston Children's—recipient of the hospital's 2015 Lifetime Impact Award—and Eric Lander, PhD, of the Broad Institute, Sankaran has establised an ambitious platform of research focused on the genetics, genomics, cellular biology and physiology of red blood cell development and red blood cell disorders such as Diamond-Blackfan anemia (DBA), sickle cell disease (SCD) and thalassemia. For instance, over a period of four years, Sankaran combined human genetics and whole genome mapping to identify the molecular switch BCL11A as a possible treatment target for SDC and thalassemia (both diseases related to hemoglobin mutations). His discoveries are fueling current efforts to affect the gene's activity therapeutically using gene editing tools (e.g., CRISPR).

In addition, Sankaran's molecular research on DBA (a severe, congenital form of anemia) has directly resulted in a unified model of DBA biology that integrates seemingly conflicting genetic discoveries about the condition into a comprehensive explanation of its biochemical underpinnings.

Most recently, Sankaran's laboratory found they could triple blood stem cells' production of red blood cells by shutting off the gene SH2B3, a target they identified by combing data from genome-wide association studies. His group believes their genetic approach could lead to better, cheaper methods of manufacturing red blood cells for transfusion and for use as drug delivery vehicles.

In 2015 Sankaran received a prestigious Young Investigator Award from the Society for Pediatric Research for his efforts to unravel red blood cell disorder genetics and development.

"[Vijay] has already established a vibrant laboratory that is using human genetics to provide clues to the defects and pathophysiology of hematologic disorders," Orkin wrote in support of Sankaran's nomination. "[I]t is hard to conceive of another young pediatric investigator who has accomplished so much in such a short time and is poised to make truly innovative discoveries going forward."

Contact:

Irene Sege
617-919-3110
irene.sege@childrens.harvard.edu

About Taking on Tomorrow

Boston Children’s Hospital’s Global Pediatric Innovation Summit + Awards 2015, Taking on Tomorrow (November 9-10, 2015), was designed to address unmet needs, solve problems and seize opportunities in pediatric health care. The 2015 theme was Precision Pediatrics.

Taking on Tomorrow featured IBM as its premier sponsor. Additional sponsors included Philips, Deloitte, Bain Capital Ventures, Genzyme, Zaffre Investments, Medtronic, American Well, Cerner Corporation, Siemens, Vertex Pharmaceuticals, athenahealth, Claritas Genomics, FKP Architects, Grunenthal and Shire. Association partners included the Institute for Healthcare Improvement, Institute for Pediatric Innovation, Massachusetts Biotechnology Council, Massachusetts Life Sciences Center, the Mass Technology Leadership Council (MassTLC), the Network for Excellence in Health Innovation, the New England Venture Capital Association and Springboard Enterprises. Media partners included boston.com, The Boston Globe, Modern Healthcare, Hospital of Tomorrow, WGBH, WBUR-90.9 FM, Xconomy and MIT Technology Review.

Follow Summit coverage online @BCH_Innovation #PedInno15 takingontomorrow.org.

About Boston Children’s Hospital

Boston Children’s Hospital is home to the world’s largest research enterprise based at a pediatric medical center, where its discoveries have benefited both children and adults since 1869. More than 1,100 scientists, including seven members of the National Academy of Sciences, 11 members of the Institute of Medicine and 10 members of the Howard Hughes Medical Institute comprise Boston Children’s research community. Founded as a 20-bed hospital for children, Boston Children’s today is a 404-bed comprehensive center for pediatric and adolescent health care. Boston Children’s is also the primary pediatric teaching affiliate of Harvard Medical School. For more, visit our Vector and Thriving blogs and follow us on our social media channels: @BostonChildrens, @BCH_Innovation, Facebook and YouTube
We are grateful to have been ranked #1 on U.S. News & World Report's list of the best children's hospitals in the nation for the third year in a row, an honor we could not have achieved without the patients and families who inspire us to do our very best for them. Thanks to you, Boston Children's is a place where we can write the greatest children's stories ever told.”
- Sandra L. Fenwick, President and CEO

Boston Children's Hospital 300 Longwood Avenue, Boston, MA 02115 617-355-6000 | 800-355-7944

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