The Asthma Clinical Research Center at Boston Children’s Hospital is studying whether the wheezing and lower respiratory tract illnesses that lead to asthma can be prevented. The goal of the study is to find if a medication called Broncho-Vaxom® can prevent wheezing lower respiratory infections and asthma in young children. Broncho-Vaxom® contains no live germs and is a mix of components of different germs that cause respiratory infections. It may work like an immunization to stimulate a child’s immune system in order to increase the body’s natural defenses against a wide number of germs that cause children to have respiratory illnesses.
Eligibility for Participation
• Babies who are 5-17 months old
• Diagnosis of eczema or atopic dermatitis
• Parental history of asthma
The study consists of a two year treatment period, followed by one year of observation. We’ll ask you to come in for a total of 12 clinic visits over the three years of the study. We will also ask you to complete telephone calls about once a month and respond to weekly text messages.
We will give you a packet of capsules at your clinic visits. Your child will randomly (like flipping a coin) be assigned to the treatment phase of the study, where he/she will receive Broncho-Vaxom® or placebo (looks and feels like study drug but doesn’t have any medication). We’ll ask you to pull the capsule apart and pour the powder into something your child will drink, and give your child the capsules for 10 days each month over two years.