Leber's Hereditary Optic Neuropathy, or LHON, causes a painless loss of central vision in people with the condition when they’re between 12 and 30 years old. It’s associated with a mutation in mitochondrial DNA, which is inherited only from a child’s mother.
- LHON was the first human disease associated with a mutation in mitochondrial DNA.
- Both eyes are affected at the same time.
- Males will not pass the gene to any of their children, but females with the mutation will pass it to all of their children, regardless of whether they are sons or daughters.