KidsMD Health Topics

Food Allergy

  • A food allergy is an abnormal response to a certain food; if your child has a food allergy, exposure to that food causes an immune system response, causing symptoms that range from uncomfortable to life-threatening.

    • If your child has a food allergy, an allergic reaction will occur the second time your child is exposed to that particular food (although, in some cases, the child could be sensitized through breast milk).

    • Ninety percent of food allergies are caused by the following six foods: Milk, Eggs, Wheat, Soy, Tree Nuts, and Peanuts.

    • Eight percent of children under age six have food allergies.

    How Children’s approaches food allergies

    Children’s diagnostic evaluations are supported by advanced allergy testing facilities, and an individual treatment plan is established for each child. Treatment may include education, medical management, and coordinated care with your child’s primary physician.

    Allergy and Asthma Program

    Contact 
    Boston Children's Hospital
    300 Longwood Avenue
    Boston, MA 02115
    617-355-2127
    Request an Appointment

    Celiac Disease Program

    Contact 
    Boston Children's Hospital
    300 Longwood Avenue
    Boston, MA 02115
    617-355-6117 
     888-IWHEEZE

     

  • How is a food allergy different from food intolerance?

    Food allergy affects your child’s immune system; food intolerance doesn’t. When your child ingests or is exposed to a food he or she is allergic to, antibodies react with the food and histamines are released, which can cause your child to experience the symptoms of food allergy.

    What are the symptoms? When do they occur?

    Allergic symptoms may begin anywhere between a few minutes to an hour after your child ingests the food to which he or she is allergic. Each child may experience symptoms differently, but the most common include:

    • Vomiting
    • Diarrhea
    • Cramps
    • Hives
    • Swelling
    • Eczema
    • Itching or swelling of the lips, tongue, or mouth
    • Itching or tightness in the throat
    • Difficulty breathing
    • Wheezing
    • Lowered blood pressure

    According to the National Institute of Allergy and Infections disease, even a small amount of the food can cause a severe reaction in a highly allergic child; even a tiny particle of a peanut can cause a reaction in some severely allergic individuals.

    Are the symptoms different for a milk or soy allergy?

    Yes. Allergies to milk and soy are often seen in infants and young children, and the symptoms may include:

    • Colic
    • Blood in your child’s stool
    • Poor growth

    Your child’s physician may change your baby’s formula to a soy formula or breast milk if it is thought that he or she is allergic to milk; if your baby has problems with soy formula, your child’s physician may suggest a hypoallergenic formula.

    Will my child outgrow a food allergy?

    Many children do “outgrow” their allergies, but allergies to peanuts, tree nuts, fish, and shellfish may be life-long.

    Can food allergies be prevented?

    The development of food allergies can not be prevented, but they can often be delayed by following these recommendations:

    • If possible, breastfeed your infant for the first six months
    • Do not give your child solid foods until he or she is six months of age or older
    • Avoid feeding your child cow’s milk, wheat, eggs, peanuts, and fish during the first year of your child’s life.

    Can a child with food allergies dine out in a restaurant?

    Dining out can be a challenge for a child with one or more food allergies. However, it is possible. The American Dietetics Association suggests:

    • Know what ingredients are in the foods at the restaurant where you plan to eat. If possible, obtain a menu in advance.

    • Let your server know right away about your child’s food allergy. Ask about preparation and ingredients before you order, and if your server seems unsure, ask to speak to the manager or chef.

    • Avoid buffets, as there may be cross-contamination from shared serving utensils.

    • Avoid fried foods, as the same oil may be used to fry several different foods (for example, French fries and popcorn shrimp).

    • A “Food Allergy Card,” detailing the specific items your child is allergic to as well as additional information to make your child’s meal “safe,” can be downloaded from the internet and presented to your server.

  • The symptoms of food allergy may resemble other problems or medical conditions, so you should always consult your child’s physician for a diagnosis.

  • There is no medication to prevent food allergy. After your child's physician discovers which foods your child is allergic to, it is important that your child avoid these foods (and other similar foods). If you are breastfeeding, you too must avoid foods that your child is allergic to.

    • Your child's physician may prescribe an emergency kit which contains epinephrine, which helps stop the symptoms of sever reactions
    • Some children, under the direction of a physician, may be given certain foods again after 3 to 6 months to see if he or she has outgrown the allergy.

    Jeff Little, Food AllergyLittle goes a long way to help patients with food allergies

    As Children's official food shopper for children with allergies, Jeffrey Little, MS, RN, LDN finds ways patients can safely eat while they're in the hospital by buying food just for them at local grocery stores and overseeing the patient line responsible for preparing the meals in Children's kitchen. "Multiple allergies are becoming more and more prevalent in our patients," he says. "Sometimes you think 'What can I feed this child?'"

    Read more: www.childrenshospital.org/dream/dream_fall07/jeff_little.html

  • One EpiPen may not be enough

    With food allergies on the rise, more children are carrying self-injectable epinephrine, better known as EpiPens, in case of severe anaphylactic reactions. A six-year review of emergency department data, published in the April issue of Pediatrics, now suggests that one EpiPen may not be enough.

    Researchers at Children’s Hospital Boston, in collaboration with Massachusetts General Hospital, reviewed data from 1,255 children who visited an emergency department for food-related allergic reactions. More than half had anaphylaxis, and of those given epinephrine, 12 percent had a resurgence of symptoms (such as trouble breathing, skin rashes or swelling) requiring a second dose.

    "Until we're able to clearly define who is at risk for the most severe reactions, it may be safest to have all children at risk for food-related anaphylaxis carry two doses of epinephrine," says first author Susan Rudders, MD, of Children's Division of Allergy and Immunology. She also suggests that school nurses could stock extra doses as a cost-saving approach.

  • Fighting food allergies

    http://www.childrenshospital.org/dream/fall09/food_allergies.html

    It’s not unusual for parents to feel the pangs of separation anxiety on the first day of school. But when Robyn Nasuti gave her 5-year-old son, Brett, a goodbye kiss as she left him at pre-school, she wasn’t worried about whether he’d make friends or get homesick. Brett has life-threatening food allergies, and in the past, Robyn had entrusted his care only to family members, having decided that the chance of him getting exposed to a potentially deadly food at daycare or with babysitters was too high. In fact, he was so sensitive that when people kissed him after eating certain foods, a hive would balloon up on his cheek in the shape of their lips. “Most people give their kids to the school system for them to be educated, but we handed over Brett and said, ‘Please keep him alive,’” says Robyn.

    That first day of school, Robyn sat in her car in the parking lot for hours, waiting for disaster to strike. Sure enough, when a little boy sitting near Brett opened a snack containing peanut butter, Brett was consumed by wheezing fits so severe that he had to be hospitalized for two days. “I ran in to see him struggling to breathe,” Robyn remembers. It wasn’t the first time she’d seen Brett gasping for air. Once, the mere smell of a quiche baking in the oven prompted an asthma attack that landed him at his doctor’s office. Another time, a bite of his dad’s birthday cake caused him to balloon up, turn purple and break out in a rash from head to toe, and they whisked him to the ER.

    Robyn and her husband, Alan, had lived with a steady feeling of alarm since Brett was 1, when a phone call from an allergist explained Brett’s near-constant bouts of hives, eczema and rashes. She sobbed as she heard, ‘Brett tested positive for wheat, soy, spelt, dairy, egg, nuts…oh God …you’d better get him in here, he needs an EpiPen…barley, oat, corn, lamb, beef, penicillin, tree pollen, ragweed, mildew, mold, cat and dog….’ Brett had 21 allergies all together, 15 of which were food. “We were completely overwhelmed,” says Robyn. “I thought, ‘How will I ever feed him?’ ”

    The allergic generation
    By the time Brett was 2, the Nasutis had seen five allergists but were still desperate for advice. Eventually, they came to Children’s Hospital Boston’s Allergy Program, where nutritionists, psychologists and doctors helped them manage Brett’s allergies, eczema and asthma. In addition to “How can we feed him?” the big question on the Nasutis’ minds was, “How did this happen?“

    The Allergy Program’s Director, Lynda Schneider, MD, provided some insight. According to her, about 7 percent of children are allergic to foods—a number that’s thought to have doubled over the last 10 years. The number of new patients with food allergies at Children’s increased dramatically, from 14 percent in 1998 to 46 percent in 2005. But what’s behind the jump is another matter. “We know that genes are involved and we know that the amount of exposure a person has to an allergen, and the age of that exposure, are likely important factors,” Schneider says.

    Researchers at Children’s are considering a wide range of other possibilities. One theory suggests that improved vaccines and a generally cleaner culture (with potent cleaning agents, ubiquitous hand sanitizer and purer water supplies) have caused Westerners’ immune systems to over-react. The rates of diseases like salmonella, Hepatitis A and measles are much lower than in the past, and we’re exposed to fewer bacteria and infections. We’re also treated with more antibiotics for infectious diseases. These health improvements could mean that our immune systems are essentially lazier than they used to be. Without having to put in overtime doing their traditional jobs of infection-fighting, their skills have become less sharp and they may misidentify harmless foods as threats. Another factor under investigation is diet. For example, the bacterial content of the gut, which is affected by food, could have strong effects on the immune system. Other studies show that maternal diets with lots of antioxidants and vegetables are associated with reduced asthma in children, while vitamin D deficiency is associated with higher rates of asthma.

    The dairy dose
    While researchers search for clear answers, Schneider and her colleague, Dale Umetsu, MD, PhD, are tackling food allergies head-on. In March, Brett, who’s now 11 and has outgrown all of his allergies except to dairy, nuts and eggs, became Children’s first patient to go through a groundbreaking study to train severely allergic patients’ immune systems to tolerate milk. Much like environmental allergy shots, patients get exposed to tiny amounts of the allergen over many months—in this case, by drinking cow’s milk—so their immune systems become desensitized and don’t react to it. Until recently, the only treatment for allergies was avoiding the food and managing any reactions. Children’s desensitization trial—the first of its kind in the country—represents a bold new way of thinking about food allergies. “I’ve been waiting 10 years for this,” says Brett. “I’d do anything to get rid of my milk allergies. After the study, I might be able to have milk with all my friends.”

    At the start of the study, Brett got regular injections of anti-IgE (Xolair), a medicine that helps block the protein responsible for setting off allergic reactions. Schneider and Umetsu had found that this medicine helped children with allergy-related asthma, and theorized that it could prevent reactions that would likely occur as patients drank the milk. Now, after getting the injections in his thighs for eight weeks, Brett is ready to taste his very first sip of milk—something he’s avoided like poison his whole life, and that he knows could still hurt him.

    A team of doctors stands by with six intravenous medications, ready to shoot them into Brett’s IV to stop any allergic reactions. Nurses carefully monitor his vital signs and fill a tiny syringe with less than a milliliter of the creamy liquid. Lying on the hospital bed wearing a new “Got Milk?” shirt that Robyn gave him to mark the occasion, Brett steels himself. “I’m a little nervous because there’s a big chance I’m going to have a reaction,” he says. He squeezes it into his mouth, making a terrible face. “It’s like nothing like I’ve ever tasted before,” he says. And then after a pause decides, “It was good. I liked it.”

    Brett soars through the first “milk challenge” unscathed, and every week returns for more. He gets regular Xolair injections and knocks back bigger and bigger shots of milk. Slowly, his resistance increases, and after a few months, he’s drinking milk in gulps every single day. “It’s absolutely amazing,” says Robyn. “Before, he couldn’t be near anyone drinking milk, and now, this.” After a few more months, Brett will stop getting injections and, if all goes well, he’ll still be reaction-free.

    A family affair
    If the desensitization is successful, it would ease the burden on the whole Nasuti family. “Our stress level goes up and down,” says Robyn. “At first, when Brett was diagnosed, we read everything we could get our hands on, which made us more overwhelmed. We never went out. But we started to realize that we needed to teach Brett how to live in this world, so we started calming down and figuring out ways to keep him safe.” They devised strategies, like cooking his food in separate pots and pans and carrying “allergy cards” to give to chefs at trusted restaurants so the kitchen staff had a list of forbidden foods while preparing Brett’s meal.

    But their stress level jumped back into the red when Brett’s little brother, Nicholas, was born with 16 food allergies that, as luck would have it, didn’t completely overlap with Brett’s. Nicholas, now 5, sums it up best: “I’m allergic to bananas, dairy, wheat, eggs, milk and everything else.” Amazingly, Brett’s sister doesn’t have any allergies, but helping her deal with her brothers’ conditions comes with its own challenges. She obeys strict rules: She can’t drink out of certain glasses, has to meticulously wipe up her crumbs, eat her crackers at the counter, wash her hands and mouth before touching her brothers and keep her food in designated “off-limits” drawers.

    There’s nothing routine about meal times at the Nasuti house. “It’s a bit of a challenge because we have to make three different meals every time we eat,” says Robyn. “Cooking takes a long time.” So does food shopping. Robyn drives to three different grocery stores in order to find allergy-friendly foods for each boy, like dairy- and egg-free pizza crusts and gluten-free cereal. And these specialty foods don’t come cheap; dairy-free milk alone costs her $10 a gallon. “I spend about $850 a month on groceries,” Robyn says.

    The most important thing Robyn has learned about food shopping is to reread food labels, no matter how many times she’s bought something. “I’ve had too many accidental ingestions because a product changed its ingredients,” she says. Two years ago while food shopping, she opened a brand of chips she’d bought for years, without glancing at the label, and gave one to Nicholas. Within minutes, he complained that his was mouth on fire. “These chips are no good, Mommy,” he said, as hives erupted down his neck and he started coughing. “He ended up going into anaphylaxis and was taken out in an ambulance,” Robyn says. “The company had added a sour cream flavored line and I didn’t realize it.”

    Certain stores know the family well: Robyn has made friends with workers at deli counters, who know they need to change their gloves after touching each food item, wipe down the scale in case of cheese residue and make sure they clean the slicer in between cuttings, to make absolutely sure that Brett’s chicken won’t contaminate Nicholas’ pork.

    The power of pizza
    While crossing one of the boys’ milk allergies off the family’s lengthy list may sound insignificant, it would make a big difference to Brett. He’s had to be hyper-vigilant in avoiding products that contain even the smallest trace of eggs, peanuts and dairy, which can lurk in everything from bread to hand soaps, lotions to shampoos. He’s had to bring his own food to parties, carry EpiPens with him everywhere in case of life-threatening anaphylactic shock, and ask his friends to wash their hands and faces when they come to his house. In elementary school, he had to sit at the peanut-free table and couldn’t sit near anyone drinking milk.

    He’s also had to deal with a fair amount of pre-teen persecutors—classmates who see his allergies as a weakness and, in typical middle school fashion, prey on it. “There are a couple of bullies in my life and I’m always afraid they’ll punch me out one day because of my allergies,” Brett says. “They call me things like Peanut Boy and tease me.” Once, a classmate thrust a peanut butter sandwich in Brett’s face when their teacher left the room—an assault that Robyn felt was the equivalent of “a kid taking out a knife.”

    Despite the bullies and constantly being on high alert, Brett is incredibly well-adjusted. “I tell my friends that mostly it doesn’t affect me, and it’s something normal kids have,” he says. “Some kids are born with allergies and some kids catch it along the way. I don’t worry a lot about it.” A dedicated Boy Scout, Brett’s also about to try for his black belt in karate, which he started when he was 5 to give him the confidence and self-discipline to manage both his allergies and the bullies.

    Not all of the patients in the Allergy Program have adapted so well. Some struggle with the stigma and others become overly anxious about the possibility of having food allergy reactions. Sometimes, children can be so worried that they develop obsessive-compulsive disorder and repeatedly wash their hands or wipe the table in case there are allergens, or refuse to eat anything they didn’t see being prepared or use utensils that aren’t theirs.

    Brett, on the other hand, could be the poster child for living well with food allergies. He’s taken it upon himself to educate his peers by organizing an annual Food Allergy Awareness week at school, during which he raises money for research. He’s even traveled to Washington, D.C., to lobby for food allergy legislation. “He’s quite the advocate, and now wants to be President to keep other people safe,” says Robyn.

    An allergy-free future?
    As Brett nears the end of the study, his doctors are hopeful that he’ll be its first success story. “If this works, it would be a totally new way to approach food allergies,” says Umetsu. “We’re starting with milk, but we believe this process could be applied to any food. Hopefully, in the near future, we can tell patients, ‘We can cure your food allergies.’ It’s a totally new era.”

    If Brett passes the final milk challenge without having a reaction, he’ll need to keep drinking milk on a regular basis for many years, to make sure his tolerance doesn’t slip. He’ll still have to be careful and carry an EpiPen for his egg and peanut allergies, but for now, he’s focused on one thing. “I’ve thought about drinking milk my whole life,” he says. “But mostly I want to eat real pizza with real cheese, not soy cheese. I think that would be really awesome.”

    Milk Allergies

    http://www.childrenshospital.org/dream/spring2007/when_food_can_kill.html

    Shock. It describes Denise Bunning's state as she watched her 6-month-old son, Bryan, take his first sip of infant formula. It also describes Bryan's violent allergic response— anaphylactic shock. His eyes rolled back, his lips and tongue swelled and he nearly stopped breathing. Still in her nightgown, Denise rushed him from their Chicago high-rise to her nearby pediatrician, where emergency treatment saved his life.

    Bryan Family, Food Allergy Bryan's milk, egg and nut allergies—and, later, his baby brother Daniel's—drastically altered the family's life and motivated Denise, a former teacher, and her husband, David, a former hedge fund manager, to seek answers. In 2002, they created the Food Allergy Foundation, whose recent $3.5 million gift to Boston Children's Hospital promises to change the prognosis for the 11 million children and adults suffering from food allergies. Thanks to the Bunnings' vision, Children's Division of Allergy and Immunology is poised to unravel the mysteries of this deadly, disabling and poorly understood disease.

    National epidemic
    With food-induced anaphylaxis in children and adults responsible for 150 to 200 deaths a year, David and Denise learned to be vigilant. Knowing that a single bite of the wrong food can be fatal affects grocery shopping, family meals, birthday parties, school lunches and restaurant trips. It means living with unremitting stress and fear. To help cope, Denise formed the first food allergy support group in Illinois in 1997—and watched Chicago-area membership burgeon to 250 families.

    But it wasn't just a local phenomenon. A national school nurse study, which the Bunnings funded, showed food allergies affect an average of 10 children in every elementary school in the United States. "It's an epidemic no one really understands," asserts David. "And it developed so fast, there's been no time for organization. To find effective treatments and cures, the federal government must get involved. Currently the National Institutes of Health (NIH) allocates $40 million annually to asthma, but only $8 million to food allergy. We'd like to change that."

    The Bunnings' Food Allergy Project raises awareness among lawmakers and the public through advocacy and education. It also awards grants for promising research. "By priming the pump with private funding, we hope to attract NIH support for allergy research," says David. "That's our ultimate goal." The Bunnings are counting on Children's researcher Dale Umetsu, MD, PhD, one of the world's foremost experts in allergic diseases, to speed that breakthrough.

    Allergy advances

    "Previously, our food allergy research had been part of a broader look at the immunobiology of allergies in general," says Umetsu. "The Bunnings' start-up money allows us to sharpen the focus on food allergy—and boost it to the next level." This gift helps develop the division's infrastructure by enabling Children's to acquire the latest analytical equipment and provide support for young, talented investigators. It will accelerate current research and allow for pilot studies. "To develop good therapies, we need to understand the basic science—what causes allergies and what prevents them in non-allergic people," Umetsu says. "We can draw on Children's large patient population for more extensive study, comparing individual immune systems at the cellular and genetic level. This is key to understanding why food allergies have become so widespread."

    One of the most promising research areas aims to "reverse" allergies by developing treatments or vaccines that either stimulate a "normal" response or block an inappropriate immune response. For example:

    • Umetsu and colleagues were the first to identify a four-member family of genes—T-cell immunoglobulin mucin (TIM) —that plays a critical role in the development of allergy and asthma. One family member, ethe TIM-1 gne, shows a special interaction with the hepatitis A virus that seems to protect against allergy.
    • In animal studies of anaphylaxis, Umetsu's group discovered a new role for a common bacteria called Listeria. When combined with other agents, Listeria can act as a catalyst to induce specific protection against food-triggered anaphylaxis, as well as allergy and asthma.
    • Umetsu's team recently discovered a new type of immune system T-cell—called natural killer T (NKT)—that is prominent in asthma. They're investigating whether NKT cells are important in food allergy and whether new therapies to block NKT function could block food allergy development

    "Good things happen when you have a world-class group like Children's Division of Allergy/Immunology," says David Bunning. "With Dr. Raif Geha, Dr. Umetsu and the entire research enterprise, and Dr. Lynda Schneider's food allergy and asthma clinic, everything is so advanced, productive and organized. We can imagine a not-too-distant future where we'll have immune therapies, like those for asthma, moderating food allergy's deadliest reactions. For so many families like ours, who live on heightened alert, it would be a huge relief."

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