Encouraged by these remissions -- albeit temporary ones -- Farber declared that folic acid antagonists opened “A promising direction for future research concerning the nature and treatment of acute leukemia in children.” In the years to follow, research programs aimed at finding better and longer lasting treatments for leukemia, and indeed other cancers, escalated worldwide. Aminopterin was later replaced by methotrexate, a more effective folic acid antagonist with fewer toxic effects, and by the 1950s other agents such as corticosteroids were produced and found to also be effective in treating acute leukemia. “Now, we are an army on the march,” Farber told Redbook magazine in 1963. Headlines of the era trumpeted optimism: “Cancer is Yielding Up its Secrets,” the Saturday Evening Post declared in 1964.