A variety of blood cells are formed in the bone marrow, and following transfusion of blood into a recipient, individual cells differ in their migration patterns. Because of the blood cells’ immune system functions, the Joint Program studies how they leave circulation to go into various tissues, and how they move between compartments within the tissues. An understanding of these mechanisms has direct relevance to hematopoietic stem cell transplantation used for the treatment of leukemia, as well as hereditary disorders like immunodeficiency syndromes and blood disorders.
