TP Singh, MD

Tajinder (TP) Singh, MD, MSc

Associate in Cardiology

Assistant Professor of Pediatrics, Harvard Medical School

    Contact: 617-355-6329
  • Fax: 617-734-9930

"My personal philosophy has always been to understand as deeply as is possible; to get to the bottom of things and then take the larger view of what it all really means."

Medical Services

Specialties

  • Cardiac Transplantation
  • Heart Failure
  • Cardiology

Departments

  • Cardiology
  • Cardiovascular Program

Languages

  • English

Programs

  • Heart Transplant Program
To schedule an appointment: Call 617-355-6329 or Request an Appointment
TP Singh, MD

I went to medical school in New Delhi and was introduced to the field of Pediatric Cardiology when Drs. Lock and Keane from Boston Children’s Hospital visited to perform cardiac interventions in children. 

I knew then that I wanted to become a pediatric cardiologist. My clinical expertise is in taking care of children with reduced heart function, those who are awaiting heart transplant and children who have received heart transplant. I am also a clinical researcher with an interest in advancing knowledge in my field, specifically in improving outcomes in children with heart failure and after transplant, and in improving understanding of cardiovascular physiology in children in health and disease.


Finally, I am a teacher and enjoy sharing the current state of knowledge with medical students, pediatric residents and cardiology fellows as it applies to clinical practice. Even as I teach what I know, I have always considered myself a life-long student first. My personal philosophy while learning or teaching has always been to understand as deeply as is possible; to get to the bottom of things and then take the larger view of what it all really means. 

Experience and Education

Education

MBBS

Maulana Azad Medical College, University of Delhi, 1984

New Delhi, INDIA

Medical School - Pediatrics

Maulana Azad Medical College, University of Delhi, 1989

New Delhi, INDIA

Residency - Pediatrics

Maulana Azad Medical College & Associated LNJP Hospital, 1990

New Delhi, INDIA

Residency - Pediatrics

Children's Hospital of Michigan, 1993

Detroit, MI

Fellowship - Pediatric Cardiology

Children's Hospital of Michigan, 1996

Detroit, MI

Fellowship - Cardiac PET, Cardiac Transplant

Children's Hospital of Michigan, 1997

Detroit, MI

Master's of Science - Clinical Research Design & Statistical Analysis

University of Michigan, 2005

Ann Arbor, MI

Certifications

  • Pediatrics, Pediatric Cardiology

Professional History

Dr. Singh joined the Cardiovascular and Heart Transplant Program in 2005. He was previously Medical Director of the Heart Transplant Program at Children's Hospital of Michigan from 1998-2005. He is a physician-scientist-teacher with an area of excellence in Clinical Expertise and Innovation. He is passionate about improving survival and quality of life in children with heart failure and heart transplantation.


During the fourth year of his Pediatric Cardiology fellowship at Children’s Hospital of MI, Dr. Singh spent several months as a visiting fellow at three pediatric heart transplant programs to learn their best clinical practices. Immediately after completing his fellowship, Dr. Singh helped Children’s Hospital of MI start its heart transplant program and was the Medical Director of the program for 7 years. Dr. Singh also directed the Exercise Physiology Laboratory and performed echocardiograms in Michigan. He was recruited to join the heart failure and transplant team at Boston Children's Hospital in 2005.


In addition to taking care of children at BCH, Dr. Singh am currently an Associate Professor of Pediatrics at Harvard Medical School. He is also the Chair of the Pediatric Council of the International Society of Heart and Lung Transplantation (2015-17). 

Research

Dr. Singh is a clinical researcher with an interest in (1) outcomes in children with heart failure and transplant, and (2) cardiovascular physiology (exercise physiology, cardiac innervation, vascular physiology, myocardial metabolism) in children with congenital and acquired heart disease. He has published several studies describing risk factors of mortality in children while waiting and after transplant.

Publications

Publications powered by Harvard Catalyst Profiles
  1. Garbern JC, Gauvreau K, Blume ED, Singh TP. Is Myocarditis an Independent Risk Factor for Post-Transplant Mortality in Pediatric Heart Transplant Recipients? Circ Heart Fail. 2016 Jan; 9(1):e002328.
  2. Schumacher KR, Almond C, Singh TP, Kirk R, Spicer R, Hoffman TM, Hsu D, Naftel DC, Pruitt E, Zamberlan M, Canter CE, Gajarski RJ. Predicting graft loss by 1 year in pediatric heart transplantation candidates: an analysis of the Pediatric Heart Transplant Study database. Circulation. 2015 Mar 10; 131(10):890-8.
  3. Singh TP, Givertz MM, Gauvreau K. Risk stratification for in-hospital mortality after heart transplantation using the modification of diet in renal disease and the chronic kidney disease epidemiology collaboration equations for estimated glomerular filtration rate. Transplantation. 2014 Nov 15; 98(9):1000-6.
  4. Singh TP, Blume ED, Alexander PM, Gauvreau K. Association of hemodynamic profiles with wait-list mortality in children listed for heart transplantation with idiopathic dilated cardiomyopathy. Am J Cardiol. 2015 Jan 15; 115(2):243-8.
  5. Hsich EM, Starling RC, Blackstone EH, Singh TP, Young JB, Gorodeski EZ, Taylor DO, Schold JD. Does the UNOS heart transplant allocation system favor men over women? JACC Heart Fail. 2014 Aug; 2(4):347-55.
  6. Schumacher KR, Singh TP, Kuebler J, Aprile K, O'Brien M, Blume ED. Risk factors and outcome of Fontan-associated plastic bronchitis: a case-control study. J Am Heart Assoc. 2014; 3(2):e000865.
  7. Singh TP, Milliren CE, Almond CS, Graham D. Survival benefit from transplantation in patients listed for heart transplantation in the United States. J Am Coll Cardiol. 2014 Apr 1; 63(12):1169-78.
  8. VanderPluym C, Graham DA, Almond CS, Blume ED, Milliren CE, Singh TP. Survival in patients removed from the heart transplant waiting list before receiving a transplant. J Heart Lung Transplant. 2014 Mar; 33(3):261-9.
  9. Singh TP. Letter by Singh Regarding Article, "Berlin Heart EXCOR pediatric ventricular assist device for bridge to heart transplantation in US children". Circulation. 2013 Nov 12; 128(20):e405.
  10. Daly KP, Chandler SF, Almond CS, Singh TP, Mah H, Milford E, Matte GS, Bastardi HJ, Mayer JE, Fynn-Thompson F, Blume ED. Antibody depletion for the treatment of crossmatch-positive pediatric heart transplant recipients. Pediatr Transplant. 2013 Nov; 17(7):661-9.
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  12. Oliva M, Singh TP, Gauvreau K, Vanderpluym CJ, Bastardi HJ, Almond CS. Impact of medication non-adherence on survival after pediatric heart transplantation in the U.S.A. J Heart Lung Transplant. 2013 Sep; 32(9):881-8.
  13. Singh TP, Almond CS, Piercey G, Gauvreau K. Risk stratification and transplant benefit in children listed for heart transplant in the United States. Circ Heart Fail. 2013 Jul; 6(4):800-8.
  14. Lytrivi ID, Blume ED, Rhodes J, Dillis S, Gauvreau K, Singh TP. Prognostic value of exercise testing during heart transplant evaluation in children. Circ Heart Fail. 2013 Jul; 6(4):792-9.
  15. Singh TP. Prospective trial of a pediatric ventricular assist device. N Engl J Med. 2012 Nov 29; 367(22):2159; author reply 2160-1.
  16. Singh TP, Almond CS, Piercey G, Gauvreau K. Current outcomes in US children with cardiomyopathy listed for heart transplantation. Circ Heart Fail. 2012 Sep 1; 5(5):594-601.
  17. Singh TP, Almond CS, Taylor DO, Milliren CE, Graham DA. Racial and ethnic differences in wait-list outcomes in patients listed for heart transplantation in the United States. Circulation. 2012 Jun 19; 125(24):3022-30.
  18. Singh TP. Letter by Singh regarding article, "Peak oxygen uptake correlates with survival without clinical deterioration in ambulatory children with dilated cardiomyopathy". Circulation. 2012 May 1; 125(17):e634; author reply e635.
  19. Singh TP, Almond CS, Semigran MJ, Piercey G, Gauvreau K. Risk prediction for early in-hospital mortality following heart transplantation in the United States. Circ Heart Fail. 2012 Mar 1; 5(2):259-66.
  20. Almond CS, Gauvreau K, Canter CE, Rajagopal SK, Piercey GE, Singh TP. A risk-prediction model for in-hospital mortality after heart transplantation in US children. Am J Transplant. 2012 May; 12(5):1240-8.
  21. Singh TP, Almond CS, Taylor DO, Graham DA. Decline in heart transplant wait list mortality in the United States following broader regional sharing of donor hearts. Circ Heart Fail. 2012 Mar 1; 5(2):249-58.
  22. Rajagopal SK, Yarlagadda VV, Thiagarajan RR, Singh TP, Givertz MM, Almond CS. Pediatric heart failure and worsening renal function: association with outcomes after heart transplantation. J Heart Lung Transplant. 2012 Mar; 31(3):252-8.
  23. Singh TP, Almond CS, Piercey G, Gauvreau K. Trends in wait-list mortality in children listed for heart transplantation in the United States: era effect across racial/ethnic groups. Am J Transplant. 2011 Dec; 11(12):2692-9.
  24. Ford MA, Almond CS, Gauvreau K, Piercey G, Blume ED, Smoot LB, Fynn-Thompson F, Singh TP. Association of graft ischemic time with survival after heart transplant among children in the United States. J Heart Lung Transplant. 2011 Nov; 30(11):1244-9.
  25. Almond CS, Singh TP, Gauvreau K, Piercey GE, Fynn-Thompson F, Rycus PT, Bartlett RH, Thiagarajan RR. Extracorporeal membrane oxygenation for bridge to heart transplantation among children in the United States: analysis of data from the Organ Procurement and Transplant Network and Extracorporeal Life Support Organization Registry. Circulation. 2011 Jun 28; 123(25):2975-84.
  26. Singh TP, Alexander ME, Gauvreau K, Curran T, Rhodes Y, Rhodes J. Recovery of oxygen consumption after maximal exercise in children. Med Sci Sports Exerc. 2011 Apr; 43(4):555-9.
  27. Singh TP. Letter by Singh regarding article, "Enalapril in infants with single ventricle: results of a multicenter randomized trial". Circulation. 2011 Mar 15; 123(10):e374.
  28. Gandhi R, Almond C, Singh TP, Gauvreau K, Piercey G, Thiagarajan RR. Factors associated with in-hospital mortality in infants undergoing heart transplantation in the United States. J Thorac Cardiovasc Surg. 2011 Feb; 141(2):531-6, 536.e1.
  29. Singh TP, Almond C, Givertz MM, Piercey G, Gauvreau K. Improved survival in heart transplant recipients in the United States: racial differences in era effect. Circ Heart Fail. 2011 Mar; 4(2):153-60.
  30. Singh TP, Almond CS, Gauvreau K. Improved survival in pediatric heart transplant recipients: have white, black and Hispanic children benefited equally? Am J Transplant. 2011 Jan; 11(1):120-8.
  31. Singh TP, Naftel DC, Addonizio L, Mahle W, Foushee MT, Zangwill S, Blume ED, Kirklin JK, Singh R, Johnston JK, Chinnock R. Association of race and socioeconomic position with outcomes in pediatric heart transplant recipients. Am J Transplant. 2010 Sep; 10(9):2116-23.
  32. Singh TP, Almond C. Are Angiotensin-converting enzyme inhibitors and beta-blockers ineffective in children with dilated cardiomyopathy and heart failure? J Am Coll Cardiol. 2010 Aug 31; 56(10):823; author reply 823-4.
  33. Silva JN, Canter CE, Singh TP, Gauvreau K, Piercey GE, Berul CI, Smoot LB, Blume ED, Fynn-Thompson F, Almond CS. Outcomes of heart transplantation using donor hearts from infants with sudden infant death syndrome. J Heart Lung Transplant. 2010 Nov; 29(11):1226-30.
  34. Turner DR, Muzik O, Forbes TJ, Sullivan NM, Singh TP. Coronary diameter and vasodilator function in children following arterial switch operation for complete transposition of the great arteries. Am J Cardiol. 2010 Aug 1; 106(3):421-5.
  35. Singh TP, Evans S. Socioeconomic position and heart rate recovery after maximal exercise in children. Arch Pediatr Adolesc Med. 2010 May; 164(5):479-84.
  36. Almond CS, Gauvreau K, Thiagarajan RR, Piercey GE, Blume ED, Smoot LB, Fynn-Thompson F, Singh TP. Impact of ABO-incompatible listing on wait-list outcomes among infants listed for heart transplantation in the United States: a propensity analysis. Circulation. 2010 May 4; 121(17):1926-33.
  37. Singh TP, Givertz MM, Semigran M, Denofrio D, Costantino F, Gauvreau K. Socioeconomic position, ethnicity, and outcomes in heart transplant recipients. Am J Cardiol. 2010 Apr 1; 105(7):1024-9.
  38. Singh TP, Gauvreau K, Thiagarajan R, Blume ED, Piercey G, Almond CS. Racial and ethnic differences in mortality in children awaiting heart transplant in the United States. Am J Transplant. 2009 Dec; 9(12):2808-15.
  39. Mah D, Singh TP, Thiagarajan RR, Gauvreau K, Piercey GE, Blume ED, Fynn-Thompson F, Almond CS. Incidence and risk factors for mortality in infants awaiting heart transplantation in the USA. J Heart Lung Transplant. 2009 Dec; 28(12):1292-8.
  40. Singh TP, Edwards LB, Kirk R, Boucek MM. Era effect on post-transplant survival adjusted for baseline risk factors in pediatric heart transplant recipients. J Heart Lung Transplant. 2009 Dec; 28(12):1285-91.
  41. Peiris V, Singh TP, Tworetzky W, Chong EC, Gauvreau K, Brown DW. Association of socioeconomic position and medical insurance with fetal diagnosis of critical congenital heart disease. Circ Cardiovasc Qual Outcomes. 2009 Jul; 2(4):354-60.
  42. Singh TP, Gauvreau K, Bastardi HJ, Blume ED, Mayer JE. Socioeconomic position and graft failure in pediatric heart transplant recipients. Circ Heart Fail. 2009 May; 2(3):160-5.
  43. Almond CS, Thiagarajan RR, Piercey GE, Gauvreau K, Blume ED, Bastardi HJ, Fynn-Thompson F, Singh TP. Waiting list mortality among children listed for heart transplantation in the United States. Circulation. 2009 Feb 10; 119(5):717-27.
  44. Singh TP, Rhodes J, Gauvreau K. Determinants of heart rate recovery following exercise in children. Med Sci Sports Exerc. 2008 Apr; 40(4):601-5.
  45. Singh TP, Gauvreau K, Rhodes J, Blume ED. Longitudinal changes in heart rate recovery after maximal exercise in pediatric heart transplant recipients: evidence of autonomic re-innervation? J Heart Lung Transplant. 2007 Dec; 26(12):1306-12.
  46. Chintala K, Epstein ML, Singh TP. Longitudinal changes in heart rate-corrected measures of exercise performance in children. Pediatr Cardiol. 2008 Jan; 29(1):60-4.
  47. Singh TP, Curran TJ, Rhodes J. Cardiac rehabilitation improves heart rate recovery following peak exercise in children with repaired congenital heart disease. Pediatr Cardiol. 2007 Jul-Aug; 28(4):276-9.
  48. Singh TP. Clinical trials of newly developed anti-cancer agents in children with acute leukemia. Contemp Clin Trials. 2006 Dec; 27(6):493.
  49. Singh TP, Naftel DC, Webber S, Dupuis J, Chin C, Spicer R, Schowengerdt KO, Ring WS, Morrow WR. Hyperlipidemia in children after heart transplantation. J Heart Lung Transplant. 2006 Oct; 25(10):1199-205.
  50. Stone D, Banerjee M, Dupuis J, Leleszi J, Allasio D, Singh TP. Association of parental pretransplant psychosocial assessment with post-transplant morbidity in pediatric heart transplant recipients. Pediatr Transplant. 2006 Aug; 10(5):602-7.
  51. Singh TP, Vasquez JC, Delius R, Walters HL. Neonatal heart transplantation to a physiologic single lung. J Heart Lung Transplant. 2006 Mar; 25(3):362-4.
  52. Chitlur M, Abella E, Singh TP, Savasan S. Severe neutropenia and thrombocytopenia following cardiac transplantation in a child. Pediatr Transplant. 2005 Feb; 9(1):94-6.
  53. Kulkarni A, Singh TP, Sarnaik A, Walters HL, Delius R. Sildenafil for pulmonary hypertension after heart transplantation. J Heart Lung Transplant. 2004 Dec; 23(12):1441-4.
  54. Rosenthal D, Chrisant MR, Edens E, Mahony L, Canter C, Colan S, Dubin A, Lamour J, Ross R, Shaddy R, Addonizio L, Beerman L, Berger S, Bernstein D, Blume E, Boucek M, Checchia P, Dipchand A, Drummond-Webb J, Fricker J, Friedman R, Hallowell S, Jaquiss R, Mital S, Pahl E, Pearce FB, Pearce B, Rhodes L, Rotondo K, Rusconi P, Scheel J, Pal Singh T, Towbin J. International Society for Heart and Lung Transplantation: Practice guidelines for management of heart failure in children. J Heart Lung Transplant. 2004 Dec; 23(12):1313-33.
  55. Singh TP, Rabah R, Cooper LT, Walters HL. Total lymphoid irradiation: new therapeutic option for refractory giant cell myocarditis. J Heart Lung Transplant. 2004 Apr; 23(4):492-5.
  56. Chin C, Naftel DC, Singh TP, Blume ED, Luikart H, Bernstein D, Gamberg P, Kirklin JK, Morrow WR. Risk factors for recurrent rejection in pediatric heart transplantation: a multicenter experience. J Heart Lung Transplant. 2004 Feb; 23(2):178-85.
  57. Singh TP, Forbes TF, Walters HL. Timing of heart transplantation after a recent pulmonary embolism. J Heart Lung Transplant. 2003 Jan; 22(1):98-101.
  58. Horenstein MS, Ross RD, Singh TP, Epstein ML. Carvedilol reverses elevated pulmonary vascular resistance in a child with dilated cardiomyopathy. Pediatr Cardiol. 2002 Jan-Feb; 23(1):100-2.
  59. Singh TP, Wolfe RR, Sullivan NM, McCool P, Neish SR. Assessment of progressive changes in exercise performance in patients with a systemic right ventricle following the atrial switch repair. Pediatr Cardiol. 2001 May-Jun; 22(3):210-4.
  60. Singh TP, Greer K, Muzik O, Hammond RL, Stephenson LW, Di Carli MF. Assessment of skeletal muscle ventricle tissue blood flow using positron emission tomography. Artif Organs. 2001 Apr; 25(4):306-12.
  61. Prabhu AS, Singh TP, Morrow WR, Muzik O, Di Carli MF. Safety and efficacy of intravenous adenosine for pharmacologic stress testing in children with aortic valve disease or Kawasaki disease. Am J Cardiol. 1999 Jan 15; 83(2):284-6, A6.
  62. Singh TP, Di Carli MF, Sullivan NM, Leonen MF, Morrow WR. Myocardial flow reserve in long-term survivors of repair of anomalous left coronary artery from pulmonary artery. J Am Coll Cardiol. 1998 Feb; 31(2):437-43.
  63. Singh TP, Morrow WR, Walters HL, Vitale NA, Hakimi M. Coil occlusion versus conventional surgical closure of patent ductus arteriosus. Am J Cardiol. 1997 May 1; 79(9):1283-5.
  64. Khalil A, Singh TP, Arora R, Puri RK. Pediatric hypertension: clinical profile and etiology. Indian Pediatr. 1991 Feb; 28(2):141-6.
  65. Singh TP, Humes RA, Muzik O, Kottamasu S, Karpawich PP, Di Carli MF. Myocardial flow reserve in patients with a systemic right ventricle after atrial switch repair. J Am Coll Cardiol. 2001 Jun 15; 37(8):2120-5.
  66. Muzik O, Paridon SM, Singh TP, Morrow WR, Dayanikli F, Di Carli MF. Quantification of myocardial blood flow and flow reserve in children with a history of Kawasaki disease and normal coronary arteries using positron emission tomography. J Am Coll Cardiol. 1996 Sep; 28(3):757-62.
  67. Singh TP, Sleeper LA, Lipshultz S, Cinar A, Canter C, Webber SA, Bernstein D, Pahl E, Alvarez JA, Wilkinson JD, Towbin JA, Colan SD. Association of left ventricular dilation at listing for heart transplant with postlisting and early posttransplant mortality in children with dilated cardiomyopathy. Circ Heart Fail. 2009 Nov; 2(6):591-8.
  68. Lunze FI, Colan SD, Gauvreau K, Chen MH, Perez-Atayde AR, Blume ED, Singh TP. Cardiac allograft function during the first year after transplantation in rejection-free children and young adults. Circ Cardiovasc Imaging. 2012 Nov; 5(6):756-64.
  69. Singh TP, Muzik O, Forbes TF, Di Carli MF. Positron emission tomography myocardial perfusion imaging in children with suspected coronary abnormalities. Pediatr Cardiol. 2003 Mar-Apr; 24(2):138-44.
  70. Singh TP, Faber C, Blume ED, Worley S, Almond CS, Smoot LB, Dillis S, Nasman C, Boyle GJ. Safety and early outcomes using a corticosteroid-avoidance immunosuppression protocol in pediatric heart transplant recipients. J Heart Lung Transplant. 2010 May; 29(5):517-22.
  71. Di Carli MF, Prcevski P, Singh TP, Janisse J, Ager J, Muzik O, Vander Heide R. Myocardial blood flow, function, and metabolism in repetitive stunning. J Nucl Med. 2000 Jul; 41(7):1227-34.
  72. Horenstein MS, Karpawich PP, Epstein ML, Singh TP. Transthoracic echocardiography for precardioversion screening during atrial flutter/fibrillation in young patients. Clin Cardiol. 2004 Jul; 27(7):413-6.
  73. Singh TP, Groehn H, Kazmers A. Vascular function and carotid intimal-medial thickness in children with insulin-dependent diabetes mellitus. J Am Coll Cardiol. 2003 Feb 19; 41(4):661-5.
  74. Lunze FI, Colan SD, Gauvreau K, Perez-Atayde AR, Smith RN, Blume ED, Singh TP. Tissue Doppler imaging for rejection surveillance in pediatric heart transplant recipients. J Heart Lung Transplant. 2013 Oct; 32(10):1027-33.
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