Sandro Santagata | Medical Services
Languages
- English
Sandro Santagata | Education
Undergraduate School
Neuroscience
Amherst College
1993
Graduate School
PhD, Molecular Basis of Disease
Mount Sinai Medical School
2002, New York, NY
Medical School
Mount Sinai Medical School
2002, New York, NY
Internship
Mount Sinai Medical School
2003, New York, NY
Residency
Anatomic Pathology
Brigham and Women's Hospital
2005, Boston, MA
Fellowship
Neuropathology
Brigham and Women's Hospital
2007, Boston, MA
Sandro Santagata | Certifications
- American Board of Pathology (Neuropathology)
Sandro Santagata | Publications
Imlunestrant a next-generation oral SERD overcomes ESR1 mutant resistance in estrogen receptor-positive breast cancer. JCI Insight. 2025 May 06. View Imlunestrant a next-generation oral SERD overcomes ESR1 mutant resistance in estrogen receptor-positive breast cancer. Abstract
ZNFX1 Functions as a Master Regulator of Epigenetically Induced Pathogen Mimicry and Inflammasome Signaling in Cancer. Cancer Res. 2025 Apr 03; 85(7):1183-1198. View ZNFX1 Functions as a Master Regulator of Epigenetically Induced Pathogen Mimicry and Inflammasome Signaling in Cancer. Abstract
Sharing data from the Human Tumor Atlas Network through standards, infrastructure and community engagement. Nat Methods. 2025 Apr; 22(4):664-671. View Sharing data from the Human Tumor Atlas Network through standards, infrastructure and community engagement. Abstract
Transplantation of human kidney organoids elicited a robust allogeneic response in a humanized mouse model. Kidney Int. 2025 Jun; 107(6):1011-1016. View Transplantation of human kidney organoids elicited a robust allogeneic response in a humanized mouse model. Abstract
Phase I Study of Adavosertib with Radiotherapy and Temozolomide in Newly Diagnosed Glioblastoma and Intratumoral Drug Levels in Recurrent Glioblastoma. Clin Cancer Res. 2025 Mar 17; 31(6):983-992. View Phase I Study of Adavosertib with Radiotherapy and Temozolomide in Newly Diagnosed Glioblastoma and Intratumoral Drug Levels in Recurrent Glioblastoma. Abstract
Multiomic analysis identifies suppressive myeloid cell populations in human TB granulomas. bioRxiv. 2025 Mar 15. View Multiomic analysis identifies suppressive myeloid cell populations in human TB granulomas. Abstract
Papillary Craniopharyngioma: An Integrative and Comprehensive Review. Endocr Rev. 2025 Mar 11; 46(2):151-213. View Papillary Craniopharyngioma: An Integrative and Comprehensive Review. Abstract
A window-of-opportunity trial reveals mechanisms of response and resistance to navtemadlin in patients with recurrent glioblastoma. Sci Transl Med. 2025 Feb 19; 17(786):eadn6274. View A window-of-opportunity trial reveals mechanisms of response and resistance to navtemadlin in patients with recurrent glioblastoma. Abstract
cIMPACT-NOW update 8: Clarifications on molecular risk parameters and recommendations for WHO grading of meningiomas. Neuro Oncol. 2025 Feb 10; 27(2):319-330. View cIMPACT-NOW update 8: Clarifications on molecular risk parameters and recommendations for WHO grading of meningiomas. Abstract
Contemporary prognostic signatures and refined risk stratification of gliomas: An analysis of 4400 tumors. Neuro Oncol. 2025 Jan 12; 27(1):195-208. View Contemporary prognostic signatures and refined risk stratification of gliomas: An analysis of 4400 tumors. Abstract
Multimodal Spatial Profiling Reveals Immune Suppression and Microenvironment Remodeling in Fallopian Tube Precursors to High-Grade Serous Ovarian Carcinoma. Cancer Discov. 2024 Dec 20. View Multimodal Spatial Profiling Reveals Immune Suppression and Microenvironment Remodeling in Fallopian Tube Precursors to High-Grade Serous Ovarian Carcinoma. Abstract
Skin immune-mesenchymal interplay within tertiary lymphoid structures promotes autoimmune pathogenesis in hidradenitis suppurativa. Immunity. 2024 12 10; 57(12):2827-2842.e5. View Skin immune-mesenchymal interplay within tertiary lymphoid structures promotes autoimmune pathogenesis in hidradenitis suppurativa. Abstract
Pilot Trial of Perampanel on Peritumoral Hyperexcitability in Newly Diagnosed High-grade Glioma. Clin Cancer Res. 2024 Dec 02; 30(23):5365-5373. View Pilot Trial of Perampanel on Peritumoral Hyperexcitability in Newly Diagnosed High-grade Glioma. Abstract
Epigenetic and Oncogenic Inhibitors Cooperatively Drive Differentiation and Kill KRAS-Mutant Colorectal Cancers. Cancer Discov. 2024 Dec 02; 14(12):2430-2449. View Epigenetic and Oncogenic Inhibitors Cooperatively Drive Differentiation and Kill KRAS-Mutant Colorectal Cancers. Abstract
Ovarian cancer-derived IL-4 promotes immunotherapy resistance. Cell. 2024 Dec 26; 187(26):7492-7510.e22. View Ovarian cancer-derived IL-4 promotes immunotherapy resistance. Abstract
Quality control for single-cell analysis of high-plex tissue profiles using CyLinter. Nat Methods. 2024 Dec; 21(12):2248-2259. View Quality control for single-cell analysis of high-plex tissue profiles using CyLinter. Abstract
ZNFX1 is a Novel Master Regulator in Epigenetically-induced Pathogen Mimicry and Inflammasome Signaling in Cancer. bioRxiv. 2024 Oct 21. View ZNFX1 is a Novel Master Regulator in Epigenetically-induced Pathogen Mimicry and Inflammasome Signaling in Cancer. Abstract
AKT and EZH2 inhibitors kill TNBCs by hijacking mechanisms of involution. Nature. 2024 Nov; 635(8039):755-763. View AKT and EZH2 inhibitors kill TNBCs by hijacking mechanisms of involution. Abstract
Multimodal Spatial Profiling Reveals Immune Suppression and Microenvironment Remodeling in Fallopian Tube Precursors to High-Grade Serous Ovarian Carcinoma. bioRxiv. 2024 Sep 27. View Multimodal Spatial Profiling Reveals Immune Suppression and Microenvironment Remodeling in Fallopian Tube Precursors to High-Grade Serous Ovarian Carcinoma. Abstract
Integrating spatial profiles and cancer genomics to identify immune-infiltrated mismatch repair proficient colorectal cancers. bioRxiv. 2024 Sep 26. View Integrating spatial profiles and cancer genomics to identify immune-infiltrated mismatch repair proficient colorectal cancers. Abstract
Sharing Data from the Human Tumor Atlas Network through Standards, Infrastructure, and Community Engagement. bioRxiv. 2024 Jun 30. View Sharing Data from the Human Tumor Atlas Network through Standards, Infrastructure, and Community Engagement. Abstract
Pure estrogen receptor antagonists potentiate capecitabine activity in ESR1-mutant breast cancer. NPJ Breast Cancer. 2024 Jun 08; 10(1):42. View Pure estrogen receptor antagonists potentiate capecitabine activity in ESR1-mutant breast cancer. Abstract
Pilot trial of perampanel on peritumoral hyperexcitability and clinical outcomes in newly diagnosed high-grade glioma. medRxiv. 2024 Apr 18. View Pilot trial of perampanel on peritumoral hyperexcitability and clinical outcomes in newly diagnosed high-grade glioma. Abstract
STMND1 is a phylogenetically ancient stathmin which localizes to motile cilia and exhibits nuclear translocation that is inhibited when soluble tubulin concentration increases. Mol Biol Cell. 2024 Jun 01; 35(6):ar82. View STMND1 is a phylogenetically ancient stathmin which localizes to motile cilia and exhibits nuclear translocation that is inhibited when soluble tubulin concentration increases. Abstract
Phase II Study of Eribulin plus Pembrolizumab in Metastatic Soft-tissue Sarcomas: Clinical Outcomes and Biological Correlates. Clin Cancer Res. 2024 Apr 01; 30(7):1281-1292. View Phase II Study of Eribulin plus Pembrolizumab in Metastatic Soft-tissue Sarcomas: Clinical Outcomes and Biological Correlates. Abstract
Multiplexed 3D Analysis of Immune States and Niches in Human Tissue. bioRxiv. 2024 Mar 28. View Multiplexed 3D Analysis of Immune States and Niches in Human Tissue. Abstract
NAB2::STAT6 fusions and genome-wide DNA methylation profiling: Predictors of patient outcomes in meningeal solitary fibrous tumors. Brain Pathol. 2024 Nov; 34(6):e13256. View NAB2::STAT6 fusions and genome-wide DNA methylation profiling: Predictors of patient outcomes in meningeal solitary fibrous tumors. Abstract
Quality Control for Single Cell Analysis of High-plex Tissue Profiles using CyLinter. bioRxiv. 2024 Mar 22. View Quality Control for Single Cell Analysis of High-plex Tissue Profiles using CyLinter. Abstract
Systematic characterization of antibody-drug conjugate targets in central nervous system tumors. Neuro Oncol. 2024 03 04; 26(3):458-472. View Systematic characterization of antibody-drug conjugate targets in central nervous system tumors. Abstract
Integrating Systemic Therapies into the Multimodality Therapy of Patients with Craniopharyngioma. Curr Treat Options Oncol. 2024 02; 25(2):261-273. View Integrating Systemic Therapies into the Multimodality Therapy of Patients with Craniopharyngioma. Abstract
Cell state dependent effects of Bmal1 on melanoma immunity and tumorigenicity. Nat Commun. 2024 Jan 20; 15(1):633. View Cell state dependent effects of Bmal1 on melanoma immunity and tumorigenicity. Abstract
Genomic and Immunophenotypic Landscape of Acquired Resistance to PD-(L)1 Blockade in Non-Small-Cell Lung Cancer. J Clin Oncol. 2024 Apr 10; 42(11):1311-1321. View Genomic and Immunophenotypic Landscape of Acquired Resistance to PD-(L)1 Blockade in Non-Small-Cell Lung Cancer. Abstract
Qualification of a multiplexed tissue imaging assay and detection of novel patterns of HER2 heterogeneity in breast cancer. NPJ Breast Cancer. 2024 Jan 02; 10(1):2. View Qualification of a multiplexed tissue imaging assay and detection of novel patterns of HER2 heterogeneity in breast cancer. Abstract
Comprehensive analysis reveals potential therapeutic targets and an integrated risk stratification model for solitary fibrous tumors. Nat Commun. 2023 11 18; 14(1):7479. View Comprehensive analysis reveals potential therapeutic targets and an integrated risk stratification model for solitary fibrous tumors. Abstract
Cell Spotter (CSPOT): A machine-learning approach to automated cell spotting and quantification of highly multiplexed tissue images. bioRxiv. 2023 Nov 17. View Cell Spotter (CSPOT): A machine-learning approach to automated cell spotting and quantification of highly multiplexed tissue images. Abstract
2D and 3D multiplexed subcellular profiling of nuclear instability in human cancer. bioRxiv. 2023 Nov 11. View 2D and 3D multiplexed subcellular profiling of nuclear instability in human cancer. Abstract
Targeted gene expression profiling predicts meningioma outcomes and radiotherapy responses. Nat Med. 2023 Dec; 29(12):3067-3076. View Targeted gene expression profiling predicts meningioma outcomes and radiotherapy responses. Abstract
Endocrine Therapy Synergizes with SMAC Mimetics to Potentiate Antigen Presentation and Tumor Regression in Hormone Receptor-Positive Breast Cancer. Cancer Res. 2023 10 02; 83(19):3284-3304. View Endocrine Therapy Synergizes with SMAC Mimetics to Potentiate Antigen Presentation and Tumor Regression in Hormone Receptor-Positive Breast Cancer. Abstract
Inaugural Results of the Individualized Screening Trial of Innovative Glioblastoma Therapy: A Phase II Platform Trial for Newly Diagnosed Glioblastoma Using Bayesian Adaptive Randomization. J Clin Oncol. 2023 Dec 20; 41(36):5524-5535. View Inaugural Results of the Individualized Screening Trial of Innovative Glioblastoma Therapy: A Phase II Platform Trial for Newly Diagnosed Glioblastoma Using Bayesian Adaptive Randomization. Abstract
Genomic analysis of spinal meningiomas: correlation with histopathological grade. J Neurosurg Spine. 2023 12 01; 39(6):729-733. View Genomic analysis of spinal meningiomas: correlation with histopathological grade. Abstract
A comprehensive genomic study of 390 H3F3A-mutant pediatric and adult diffuse high-grade gliomas, CNS WHO grade 4. Acta Neuropathol. 2023 09; 146(3):515-525. View A comprehensive genomic study of 390 H3F3A-mutant pediatric and adult diffuse high-grade gliomas, CNS WHO grade 4. Abstract
Impact of H3K27 trimethylation loss in meningiomas: a meta-analysis. Acta Neuropathol Commun. 2023 07 25; 11(1):122. View Impact of H3K27 trimethylation loss in meningiomas: a meta-analysis. Abstract
Chemical QuantArray: A Quantitative Tool for Mass Spectrometry Imaging. Anal Chem. 2023 08 01; 95(30):11243-11253. View Chemical QuantArray: A Quantitative Tool for Mass Spectrometry Imaging. Abstract
BRAF-MEK Inhibition in Newly Diagnosed Papillary Craniopharyngiomas. N Engl J Med. 2023 07 13; 389(2):118-126. View BRAF-MEK Inhibition in Newly Diagnosed Papillary Craniopharyngiomas. Abstract
High-plex immunofluorescence imaging and traditional histology of the same tissue section for discovering image-based biomarkers. Nat Cancer. 2023 07; 4(7):1036-1052. View High-plex immunofluorescence imaging and traditional histology of the same tissue section for discovering image-based biomarkers. Abstract
Meet the authors: Dr. Clint Allen and Dr. Sandro Santagata. Cancer Cell. 2023 05 08; 41(5):834-836. View Meet the authors: Dr. Clint Allen and Dr. Sandro Santagata. Abstract
Lymphocyte networks are dynamic cellular communities in the immunoregulatory landscape of lung adenocarcinoma. Cancer Cell. 2023 05 08; 41(5):871-886.e10. View Lymphocyte networks are dynamic cellular communities in the immunoregulatory landscape of lung adenocarcinoma. Abstract
USP9X mediates an acute adaptive response to MAPK suppression in pancreatic cancer but creates multiple actionable therapeutic vulnerabilities. Cell Rep Med. 2023 04 18; 4(4):101007. View USP9X mediates an acute adaptive response to MAPK suppression in pancreatic cancer but creates multiple actionable therapeutic vulnerabilities. Abstract
Targeted gene expression profiling predicts meningioma outcomes and radiotherapy responses. Res Sq. 2023 Mar 20. View Targeted gene expression profiling predicts meningioma outcomes and radiotherapy responses. Abstract
Hypermitotic meningiomas harbor DNA methylation subgroups with distinct biological and clinical features. Neuro Oncol. 2023 03 14; 25(3):520-530. View Hypermitotic meningiomas harbor DNA methylation subgroups with distinct biological and clinical features. Abstract
Multiplexed 3D atlas of state transitions and immune interaction in colorectal cancer. Cell. 2023 01 19; 186(2):363-381.e19. View Multiplexed 3D atlas of state transitions and immune interaction in colorectal cancer. Abstract
Visinity: Visual Spatial Neighborhood Analysis for Multiplexed Tissue Imaging Data. IEEE Trans Vis Comput Graph. 2023 01; 29(1):106-116. View Visinity: Visual Spatial Neighborhood Analysis for Multiplexed Tissue Imaging Data. Abstract
UnMICST: Deep learning with real augmentation for robust segmentation of highly multiplexed images of human tissues. Commun Biol. 2022 11 18; 5(1):1263. View UnMICST: Deep learning with real augmentation for robust segmentation of highly multiplexed images of human tissues. Abstract
Spatial genomics maps the structure, nature and evolution of cancer clones. Nature. 2022 Nov; 611(7936):594-602. View Spatial genomics maps the structure, nature and evolution of cancer clones. Abstract
Alliance A071401: Phase II Trial of Focal Adhesion Kinase Inhibition in Meningiomas With Somatic NF2 Mutations. J Clin Oncol. 2023 01 20; 41(3):618-628. View Alliance A071401: Phase II Trial of Focal Adhesion Kinase Inhibition in Meningiomas With Somatic NF2 Mutations. Abstract
Stitching and registering highly multiplexed whole-slide images of tissues and tumors using ASHLAR. Bioinformatics. 2022 09 30; 38(19):4613-4621. View Stitching and registering highly multiplexed whole-slide images of tissues and tumors using ASHLAR. Abstract
Oncometabolite d-2HG alters T cell metabolism to impair CD8+ T cell function. Science. 2022 09 30; 377(6614):1519-1529. View Oncometabolite d-2HG alters T cell metabolism to impair CD8+ T cell function. Abstract
Spatial transcriptomics. Cancer Cell. 2022 09 12; 40(9):895-900. View Spatial transcriptomics. Abstract
PD-L1 and PD-1 expression in pediatric central nervous system germ cell tumors. Mod Pathol. 2022 12; 35(12):1770-1774. View PD-L1 and PD-1 expression in pediatric central nervous system germ cell tumors. Abstract
Single cell spatial analysis reveals the topology of immunomodulatory purinergic signaling in glioblastoma. Nat Commun. 2022 08 16; 13(1):4814. View Single cell spatial analysis reveals the topology of immunomodulatory purinergic signaling in glioblastoma. Abstract
Clinical utility of targeted next-generation sequencing assay in IDH-wildtype glioblastoma for therapy decision-making. Neuro Oncol. 2022 07 01; 24(7):1140-1149. View Clinical utility of targeted next-generation sequencing assay in IDH-wildtype glioblastoma for therapy decision-making. Abstract
The Spatial Landscape of Progression and Immunoediting in Primary Melanoma at Single-Cell Resolution. Cancer Discov. 2022 06 02; 12(6):1518-1541. View The Spatial Landscape of Progression and Immunoediting in Primary Melanoma at Single-Cell Resolution. Abstract
A human breast atlas integrating single-cell proteomics and transcriptomics. Dev Cell. 2022 06 06; 57(11):1400-1420.e7. View A human breast atlas integrating single-cell proteomics and transcriptomics. Abstract
A molecularly integrated grade for meningioma. Neuro Oncol. 2022 05 04; 24(5):796-808. View A molecularly integrated grade for meningioma. Abstract
Copper induces cell death by targeting lipoylated TCA cycle proteins. Science. 2022 03 18; 375(6586):1254-1261. View Copper induces cell death by targeting lipoylated TCA cycle proteins. Abstract
HSF2 cooperates with HSF1 to drive a transcriptional program critical for the malignant state. Sci Adv. 2022 Mar 18; 8(11):eabj6526. View HSF2 cooperates with HSF1 to drive a transcriptional program critical for the malignant state. Abstract
Temporal and spatial topography of cell proliferation in cancer. Nat Cell Biol. 2022 03; 24(3):316-326. View Temporal and spatial topography of cell proliferation in cancer. Abstract
Phase 2 study of pembrolizumab in patients with recurrent and residual high-grade meningiomas. Nat Commun. 2022 03 14; 13(1):1325. View Phase 2 study of pembrolizumab in patients with recurrent and residual high-grade meningiomas. Abstract
MITI minimum information guidelines for highly multiplexed tissue images. Nat Methods. 2022 03; 19(3):262-267. View MITI minimum information guidelines for highly multiplexed tissue images. Abstract
Single-cell tumor-immune microenvironment of BRCA1/2 mutated high-grade serous ovarian cancer. Nat Commun. 2022 02 11; 13(1):835. View Single-cell tumor-immune microenvironment of BRCA1/2 mutated high-grade serous ovarian cancer. Abstract
Activity of PD-1 blockade with nivolumab among patients with recurrent atypical/anaplastic meningioma: phase II trial results. Neuro Oncol. 2022 01 05; 24(1):101-113. View Activity of PD-1 blockade with nivolumab among patients with recurrent atypical/anaplastic meningioma: phase II trial results. Abstract
Multimodal platform for assessing drug distribution and response in clinical trials. Neuro Oncol. 2022 01 05; 24(1):64-77. View Multimodal platform for assessing drug distribution and response in clinical trials. Abstract
Scope2Screen: Focus+Context Techniques for Pathology Tumor Assessment in Multivariate Image Data. IEEE Trans Vis Comput Graph. 2022 01; 28(1):259-269. View Scope2Screen: Focus+Context Techniques for Pathology Tumor Assessment in Multivariate Image Data. Abstract
MCMICRO: a scalable, modular image-processing pipeline for multiplexed tissue imaging. Nat Methods. 2022 03; 19(3):311-315. View MCMICRO: a scalable, modular image-processing pipeline for multiplexed tissue imaging. Abstract
Skull Base Tumors: Neuropathology and Clinical Implications. Neurosurgery. 2022 03 01; 90(3):243-261. View Skull Base Tumors: Neuropathology and Clinical Implications. Abstract
Narrative online guides for the interpretation of digital-pathology images and tissue-atlas data. Nat Biomed Eng. 2022 05; 6(5):515-526. View Narrative online guides for the interpretation of digital-pathology images and tissue-atlas data. Abstract
Antigen dominance hierarchies shape TCF1+ progenitor CD8 T cell phenotypes in tumors. Cell. 2021 09 16; 184(19):4996-5014.e26. View Antigen dominance hierarchies shape TCF1+ progenitor CD8 T cell phenotypes in tumors. Abstract
Interim clinical trial analysis of intraoperative mass spectrometry for breast cancer surgery. NPJ Breast Cancer. 2021 Sep 09; 7(1):116. View Interim clinical trial analysis of intraoperative mass spectrometry for breast cancer surgery. Abstract
Targeting Pin1 renders pancreatic cancer eradicable by synergizing with immunochemotherapy. Cell. 2021 09 02; 184(18):4753-4771.e27. View Targeting Pin1 renders pancreatic cancer eradicable by synergizing with immunochemotherapy. Abstract
Prognostication for meningiomas: H3K27me3 to the rescue? Neuro Oncol. 2021 08 02; 23(8):1218-1219. View Prognostication for meningiomas: H3K27me3 to the rescue? Abstract
Palbociclib demonstrates intracranial activity in progressive brain metastases harboring cyclin-dependent kinase pathway alterations. Nat Cancer. 2021 05; 2(5):498-502. View Palbociclib demonstrates intracranial activity in progressive brain metastases harboring cyclin-dependent kinase pathway alterations. Abstract
Identification and Therapeutic Targeting of GPR20, Selectively Expressed in Gastrointestinal Stromal Tumors, with DS-6157a, a First-in-Class Antibody-Drug Conjugate. Cancer Discov. 2021 06; 11(6):1508-1523. View Identification and Therapeutic Targeting of GPR20, Selectively Expressed in Gastrointestinal Stromal Tumors, with DS-6157a, a First-in-Class Antibody-Drug Conjugate. Abstract
HAND1 and BARX1 Act as Transcriptional and Anatomic Determinants of Malignancy in Gastrointestinal Stromal Tumor. Clin Cancer Res. 2021 03 15; 27(6):1706-1719. View HAND1 and BARX1 Act as Transcriptional and Anatomic Determinants of Malignancy in Gastrointestinal Stromal Tumor. Abstract
Sporadic multiple meningiomas harbor distinct driver mutations. Acta Neuropathol Commun. 2021 01 06; 9(1):8. View Sporadic multiple meningiomas harbor distinct driver mutations. Abstract
Targeting immunosuppressive macrophages overcomes PARP inhibitor resistance in BRCA1-associated triple-negative breast cancer. Nat Cancer. 2021 01; 2(1):66-82. View Targeting immunosuppressive macrophages overcomes PARP inhibitor resistance in BRCA1-associated triple-negative breast cancer. Abstract
Distinct genomic subclasses of high-grade/progressive meningiomas: NF2-associated, NF2-exclusive, and NF2-agnostic. Acta Neuropathol Commun. 2020 10 21; 8(1):171. View Distinct genomic subclasses of high-grade/progressive meningiomas: NF2-associated, NF2-exclusive, and NF2-agnostic. Abstract
Minerva: a light-weight, narrative image browser for multiplexed tissue images. J Open Source Softw. 2020; 5(54). View Minerva: a light-weight, narrative image browser for multiplexed tissue images. Abstract
SYLARAS: A Platform for the Statistical Analysis and Visual Display of Systemic Immunoprofiling Data and Its Application to Glioblastoma. Cell Syst. 2020 09 23; 11(3):272-285.e9. View SYLARAS: A Platform for the Statistical Analysis and Visual Display of Systemic Immunoprofiling Data and Its Application to Glioblastoma. Abstract
Author Correction: Immunogenomic profiling determines responses to combined PARP and PD-1 inhibition in ovarian cancer. Nat Commun. 2020 05 18; 11(1):2543. View Author Correction: Immunogenomic profiling determines responses to combined PARP and PD-1 inhibition in ovarian cancer. Abstract
Frequent inactivating mutations of the PBAF complex gene PBRM1 in meningioma with papillary features. Acta Neuropathol. 2020 07; 140(1):89-93. View Frequent inactivating mutations of the PBAF complex gene PBRM1 in meningioma with papillary features. Abstract
The Human Tumor Atlas Network: Charting Tumor Transitions across Space and Time at Single-Cell Resolution. Cell. 2020 04 16; 181(2):236-249. View The Human Tumor Atlas Network: Charting Tumor Transitions across Space and Time at Single-Cell Resolution. Abstract
Mechanisms and therapeutic implications of hypermutation in gliomas. Nature. 2020 04; 580(7804):517-523. View Mechanisms and therapeutic implications of hypermutation in gliomas. Abstract
A Deregulated HOX Gene Axis Confers an Epigenetic Vulnerability in KRAS-Mutant Lung Cancers. Cancer Cell. 2020 05 11; 37(5):705-719.e6. View A Deregulated HOX Gene Axis Confers an Epigenetic Vulnerability in KRAS-Mutant Lung Cancers. Abstract
Correction to: An update on the CNS manifestations of neurofibromatosis type 2. Acta Neuropathol. 2020 Apr; 139(4):667. View Correction to: An update on the CNS manifestations of neurofibromatosis type 2. Abstract
Genomic characterization of human brain metastases identifies drivers of metastatic lung adenocarcinoma. Nat Genet. 2020 04; 52(4):371-377. View Genomic characterization of human brain metastases identifies drivers of metastatic lung adenocarcinoma. Abstract
Immunogenomic profiling determines responses to combined PARP and PD-1 inhibition in ovarian cancer. Nat Commun. 2020 03 19; 11(1):1459. View Immunogenomic profiling determines responses to combined PARP and PD-1 inhibition in ovarian cancer. Abstract
Telomere length alterations and ATRX/DAXX loss in pituitary adenomas. Mod Pathol. 2020 08; 33(8):1475-1481. View Telomere length alterations and ATRX/DAXX loss in pituitary adenomas. Abstract
Response and mechanisms of resistance to larotrectinib and selitrectinib in metastatic undifferentiated sarcoma harboring oncogenic fusion of NTRK1. JCO Precis Oncol. 2020; 4:79-90. View Response and mechanisms of resistance to larotrectinib and selitrectinib in metastatic undifferentiated sarcoma harboring oncogenic fusion of NTRK1. Abstract
HSF1 phase transition mediates stress adaptation and cell fate decisions. Nat Cell Biol. 2020 02; 22(2):151-158. View HSF1 phase transition mediates stress adaptation and cell fate decisions. Abstract
Highly multiplexed immunofluorescence images and single-cell data of immune markers in tonsil and lung cancer. Sci Data. 2019 12 17; 6(1):323. View Highly multiplexed immunofluorescence images and single-cell data of immune markers in tonsil and lung cancer. Abstract
Localized Metabolomic Gradients in Patient-Derived Xenograft Models of Glioblastoma. Cancer Res. 2020 03 15; 80(6):1258-1267. View Localized Metabolomic Gradients in Patient-Derived Xenograft Models of Glioblastoma. Abstract
Qualifying antibodies for image-based immune profiling and multiplexed tissue imaging. Nat Protoc. 2019 10; 14(10):2900-2930. View Qualifying antibodies for image-based immune profiling and multiplexed tissue imaging. Abstract
Pre- and Postoperative Neratinib for HER2-Positive Breast Cancer Brain Metastases: Translational Breast Cancer Research Consortium 022. Clin Breast Cancer. 2020 04; 20(2):145-151.e2. View Pre- and Postoperative Neratinib for HER2-Positive Breast Cancer Brain Metastases: Translational Breast Cancer Research Consortium 022. Abstract
Targeted treatment of papillary craniopharyngiomas harboring BRAF V600E mutations. Cancer. 2019 09 01; 125(17):2910-2914. View Targeted treatment of papillary craniopharyngiomas harboring BRAF V600E mutations. Abstract
Rapid MALDI mass spectrometry imaging for surgical pathology. NPJ Precis Oncol. 2019; 3:17. View Rapid MALDI mass spectrometry imaging for surgical pathology. Abstract
Author Correction: Mitochondrial metabolism promotes adaptation to proteotoxic stress. Nat Chem Biol. 2019 Jul; 15(7):757. View Author Correction: Mitochondrial metabolism promotes adaptation to proteotoxic stress. Abstract
Rebalancing Protein Homeostasis Enhances Tumor Antigen Presentation. Clin Cancer Res. 2019 11 01; 25(21):6392-6405. View Rebalancing Protein Homeostasis Enhances Tumor Antigen Presentation. Abstract
An update on the CNS manifestations of neurofibromatosis type 2. Acta Neuropathol. 2020 04; 139(4):643-665. View An update on the CNS manifestations of neurofibromatosis type 2. Abstract
Neuronal differentiation and cell-cycle programs mediate response to BET-bromodomain inhibition in MYC-driven medulloblastoma. Nat Commun. 2019 06 03; 10(1):2400. View Neuronal differentiation and cell-cycle programs mediate response to BET-bromodomain inhibition in MYC-driven medulloblastoma. Abstract
Mitochondrial metabolism promotes adaptation to proteotoxic stress. Nat Chem Biol. 2019 07; 15(7):681-689. View Mitochondrial metabolism promotes adaptation to proteotoxic stress. Abstract
Individualized Screening Trial of Innovative Glioblastoma Therapy (INSIGhT): A Bayesian Adaptive Platform Trial to Develop Precision Medicines for Patients With Glioblastoma. JCO Precis Oncol. 2019; 3. View Individualized Screening Trial of Innovative Glioblastoma Therapy (INSIGhT): A Bayesian Adaptive Platform Trial to Develop Precision Medicines for Patients With Glioblastoma. Abstract
The impact of histopathology and NAB2-STAT6 fusion subtype in classification and grading of meningeal solitary fibrous tumor/hemangiopericytoma. Acta Neuropathol. 2019 02; 137(2):307-319. View The impact of histopathology and NAB2-STAT6 fusion subtype in classification and grading of meningeal solitary fibrous tumor/hemangiopericytoma. Abstract
New molecular targets in meningiomas: the present and the future. Curr Opin Neurol. 2018 12; 31(6):740-746. View New molecular targets in meningiomas: the present and the future. Abstract
Comprehensive Study of the Clinical Phenotype of Germline BAP1 Variant-Carrying Families Worldwide. J Natl Cancer Inst. 2018 12 01; 110(12):1328-1341. View Comprehensive Study of the Clinical Phenotype of Germline BAP1 Variant-Carrying Families Worldwide. Abstract
Mismatch repair deficiency in high-grade meningioma: a rare but recurrent event associated with dramatic immune activation and clinical response to PD-1 blockade. JCO Precis Oncol. 2018; 2018. View Mismatch repair deficiency in high-grade meningioma: a rare but recurrent event associated with dramatic immune activation and clinical response to PD-1 blockade. Abstract
Updates in prognostic markers for gliomas. Neuro Oncol. 2018 11 09; 20(suppl_7):vii17-vii26. View Updates in prognostic markers for gliomas. Abstract
Neuropathology of a Case With Fatal CAR T-Cell-Associated Cerebral Edema. J Neuropathol Exp Neurol. 2018 10 01; 77(10):877-882. View Neuropathology of a Case With Fatal CAR T-Cell-Associated Cerebral Edema. Abstract
Meningioma transcription factors link cell lineage with systemic metabolic cues. Neuro Oncol. 2018 09 03; 20(10):1331-1343. View Meningioma transcription factors link cell lineage with systemic metabolic cues. Abstract
Rapid discrimination of pediatric brain tumors by mass spectrometry imaging. J Neurooncol. 2018 Nov; 140(2):269-279. View Rapid discrimination of pediatric brain tumors by mass spectrometry imaging. Abstract
DMD genomic deletions characterize a subset of progressive/higher-grade meningiomas with poor outcome. Acta Neuropathol. 2018 11; 136(5):779-792. View DMD genomic deletions characterize a subset of progressive/higher-grade meningiomas with poor outcome. Abstract
Highly multiplexed immunofluorescence imaging of human tissues and tumors using t-CyCIF and conventional optical microscopes. Elife. 2018 07 11; 7. View Highly multiplexed immunofluorescence imaging of human tissues and tumors using t-CyCIF and conventional optical microscopes. Abstract
Multiplexed immunofluorescence reveals potential PD-1/PD-L1 pathway vulnerabilities in craniopharyngioma. Neuro Oncol. 2018 07 05; 20(8):1101-1112. View Multiplexed immunofluorescence reveals potential PD-1/PD-L1 pathway vulnerabilities in craniopharyngioma. Abstract
Integrating Genomics Into Neuro-Oncology Clinical Trials and Practice. Am Soc Clin Oncol Educ Book. 2018 May 23; 38:148-157. View Integrating Genomics Into Neuro-Oncology Clinical Trials and Practice. Abstract
Uncovering the links between systemic hormones and oncogenic signaling in the pathogenesis of meningioma. Ann Oncol. 2018 03 01; 29(3):537-540. View Uncovering the links between systemic hormones and oncogenic signaling in the pathogenesis of meningioma. Abstract
A case of molecularly profiled extraneural medulloblastoma metastases in a child. BMC Med Genet. 2018 01 17; 19(1):10. View A case of molecularly profiled extraneural medulloblastoma metastases in a child. Abstract
Orbital leiomyosarcoma metastasis presenting prior to diagnosis of the primary tumor. Digit J Ophthalmol. 2017; 23(4):22-26. View Orbital leiomyosarcoma metastasis presenting prior to diagnosis of the primary tumor. Abstract
Radiographic prediction of meningioma grade by semantic and radiomic features. PLoS One. 2017; 12(11):e0187908. View Radiographic prediction of meningioma grade by semantic and radiomic features. Abstract
BAP1 mutations in high-grade meningioma: implications for patient care. Neuro Oncol. 2017 Oct 19; 19(11):1447-1456. View BAP1 mutations in high-grade meningioma: implications for patient care. Abstract
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Osteoglycin promotes meningioma development through downregulation of NF2 and activation of mTOR signaling. Cell Commun Signal. 2017 09 18; 15(1):34. View Osteoglycin promotes meningioma development through downregulation of NF2 and activation of mTOR signaling. Abstract
Erratum: Genomic landscape of high-grade meningiomas. NPJ Genom Med. 2017; 2:26. View Erratum: Genomic landscape of high-grade meningiomas. Abstract
Clinical targeted exome-based sequencing in combination with genome-wide copy number profiling: precision medicine analysis of 203 pediatric brain tumors. Neuro Oncol. 2017 Jul 01; 19(7):986-996. View Clinical targeted exome-based sequencing in combination with genome-wide copy number profiling: precision medicine analysis of 203 pediatric brain tumors. Abstract
Clinical Identification of Oncogenic Drivers and Copy-Number Alterations in Pituitary Tumors. Endocrinology. 2017 07 01; 158(7):2284-2291. View Clinical Identification of Oncogenic Drivers and Copy-Number Alterations in Pituitary Tumors. Abstract
Genomic landscape of high-grade meningiomas. NPJ Genom Med. 2017; 2. View Genomic landscape of high-grade meningiomas. Abstract
Germline and somatic BAP1 mutations in high-grade rhabdoid meningiomas. Neuro Oncol. 2017 04 01; 19(4):535-545. View Germline and somatic BAP1 mutations in high-grade rhabdoid meningiomas. Abstract
Clinical and radiographic response following targeting of BCAN-NTRK1 fusion in glioneuronal tumor. NPJ Precis Oncol. 2017; 1(1):5. View Clinical and radiographic response following targeting of BCAN-NTRK1 fusion in glioneuronal tumor. Abstract
Fatal Eastern Equine Encephalitis in a Patient on Maintenance Rituximab: A Case Report. Open Forum Infect Dis. 2017; 4(1):ofx021. View Fatal Eastern Equine Encephalitis in a Patient on Maintenance Rituximab: A Case Report. Abstract
Rapid Mass Spectrometry Imaging to Assess the Biochemical Profile of Pituitary Tissue for Potential Intraoperative Usage. Adv Cancer Res. 2017; 134:257-282. View Rapid Mass Spectrometry Imaging to Assess the Biochemical Profile of Pituitary Tissue for Potential Intraoperative Usage. Abstract
Suppression of 19S proteasome subunits marks emergence of an altered cell state in diverse cancers. Proc Natl Acad Sci U S A. 2017 01 10; 114(2):382-387. View Suppression of 19S proteasome subunits marks emergence of an altered cell state in diverse cancers. Abstract
Potential evolution of neurosurgical treatment paradigms for craniopharyngioma based on genomic and transcriptomic characteristics. Neurosurg Focus. 2016 Dec; 41(6):E3. View Potential evolution of neurosurgical treatment paradigms for craniopharyngioma based on genomic and transcriptomic characteristics. Abstract
Diagnosis and management of craniopharyngiomas in the era of genomics and targeted therapy. Neurosurg Focus. 2016 Dec; 41(6):E2. View Diagnosis and management of craniopharyngiomas in the era of genomics and targeted therapy. Abstract
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Targeted sequencing of SMO and AKT1 in anterior skull base meningiomas. J Neurosurg. 2017 08; 127(2):438-444. View Targeted sequencing of SMO and AKT1 in anterior skull base meningiomas. Abstract
Increased expression of programmed death ligand 1 (PD-L1) in human pituitary tumors. Oncotarget. 2016 Nov 22; 7(47):76565-76576. View Increased expression of programmed death ligand 1 (PD-L1) in human pituitary tumors. Abstract
Treatment of brain metastases in the modern genomic era. Pharmacol Ther. 2017 02; 170:64-72. View Treatment of brain metastases in the modern genomic era. Abstract
Landscape of Genomic Alterations in Pituitary Adenomas. Clin Cancer Res. 2017 Apr 01; 23(7):1841-1851. View Landscape of Genomic Alterations in Pituitary Adenomas. Abstract
Distinct patterns of primary and motile cilia in Rathke's cleft cysts and craniopharyngioma subtypes. Mod Pathol. 2016 12; 29(12):1446-1459. View Distinct patterns of primary and motile cilia in Rathke's cleft cysts and craniopharyngioma subtypes. Abstract
SU-D-207B-02: Early Grade Classification in Meningioma Patients Combining Radiomics and Semantics Data. Med Phys. 2016 Jun; 43(6):3348-3349. View SU-D-207B-02: Early Grade Classification in Meningioma Patients Combining Radiomics and Semantics Data. Abstract
Checkpoint inhibition in meningiomas. Immunotherapy. 2016 06; 8(6):721-31. View Checkpoint inhibition in meningiomas. Abstract
Label-Free Neurosurgical Pathology with Stimulated Raman Imaging. Cancer Res. 2016 06 15; 76(12):3451-62. View Label-Free Neurosurgical Pathology with Stimulated Raman Imaging. Abstract
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A prognostic cytogenetic scoring system to guide the adjuvant management of patients with atypical meningioma. Neuro Oncol. 2016 Feb; 18(2):269-74. View A prognostic cytogenetic scoring system to guide the adjuvant management of patients with atypical meningioma. Abstract
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ARID1A and TERT promoter mutations in dedifferentiated meningioma. Cancer Genet. 2015 Jun; 208(6):345-50. View ARID1A and TERT promoter mutations in dedifferentiated meningioma. Abstract
Increased expression of the immune modulatory molecule PD-L1 (CD274) in anaplastic meningioma. Oncotarget. 2015 Mar 10; 6(7):4704-16. View Increased expression of the immune modulatory molecule PD-L1 (CD274) in anaplastic meningioma. Abstract
Clinical implementation of integrated whole-genome copy number and mutation profiling for glioblastoma. Neuro Oncol. 2015 Oct; 17(10):1344-55. View Clinical implementation of integrated whole-genome copy number and mutation profiling for glioblastoma. Abstract
Molecular typing of Meningiomas by Desorption Electrospray Ionization Mass Spectrometry Imaging for Surgical Decision-Making. Int J Mass Spectrom. 2015 Feb 01; 377:690-698. View Molecular typing of Meningiomas by Desorption Electrospray Ionization Mass Spectrometry Imaging for Surgical Decision-Making. Abstract
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Angiomatous meningiomas have a distinct genetic profile with multiple chromosomal polysomies including polysomy of chromosome 5. Oncotarget. 2014 Nov 15; 5(21):10596-606. View Angiomatous meningiomas have a distinct genetic profile with multiple chromosomal polysomies including polysomy of chromosome 5. Abstract
Clinical multiplexed exome sequencing distinguishes adult oligodendroglial neoplasms from astrocytic and mixed lineage gliomas. Oncotarget. 2014 Sep 30; 5(18):8083-92. View Clinical multiplexed exome sequencing distinguishes adult oligodendroglial neoplasms from astrocytic and mixed lineage gliomas. Abstract
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Application of desorption electrospray ionization mass spectrometry imaging in breast cancer margin analysis. Proc Natl Acad Sci U S A. 2014 Oct 21; 111(42):15184-9. View Application of desorption electrospray ionization mass spectrometry imaging in breast cancer margin analysis. Abstract
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Adjuvant radiation therapy, local recurrence, and the need for salvage therapy in atypical meningioma. Neuro Oncol. 2014 Nov; 16(11):1547-53. View Adjuvant radiation therapy, local recurrence, and the need for salvage therapy in atypical meningioma. Abstract
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Exome sequencing identifies BRAF mutations in papillary craniopharyngiomas. Nat Genet. 2014 Feb; 46(2):161-5. View Exome sequencing identifies BRAF mutations in papillary craniopharyngiomas. Abstract
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