MD

Richard J. Grand, MD

Director Emeritus, Inflammatory Bowel Disease Center; Director Emeritus, Clinical and Translational Study Unit

Professor of Pediatrics, Harvard Medical School

    Contact: 617-355-2962
  • Fax: 617-730-0494

Medical Services

Specialties

  • Cystic Fibrosis
  • Gastroenterology
  • Inflammatory Bowel Disease

Departments

  • Gastroenterology, Hepatology and Nutrition
  • Medicine

Languages

  • English

Programs

  • Inflammatory Bowel Disease Center
To schedule an appointment: Call 617-355-2962 or Request an Appointment

Experience and Education

Education

Undergraduate

Harvard College, 1958

Boston, MA

Medical School

New York University School of Medicine, 1962

New York, NY

Internship

Bellevue Hospital, 1963

New York, NY

Residency

Boston Children's Hospital, 1963-1967

Boston, MA

Fellowship

Boston Children's Hospital, Harvard Medical School, Massachusetts General Hospital, 1967-1970

Boston, MA

Fellowship, Completed Research Fellowship in Nutrition, Cystic Fibrosis and Gastroenterology

Boston Children's Hospital, 1969

Boston, MA

Fellowship, Completed Postdoctoral Fellowship in Biology and Nutrition

Massachusetts Institute of Technology, 1969

Boston, MA

Fellowship, Completed Research Fellowship in Medicine

Harvard Medical School , 1970

Boston, MA

Certifications

  • Pediatrics, Pediatric Gastroenterology

Research

Identification of the genetic cause of Crohn's disease and ulcerative colitis in childhood Identifcation of the genetic cause of growth failure in Crohn's disease and ulcerative colitis Treatment of bone mineral loss in children with inflammatory bowel disease Genetic control of intestinal lactase espression

Publications

Publications powered by Harvard Catalyst Profiles
  1. Ong MS, Grand RJ, Mandl KD. Trends in Pharmacologic Interventions for Preventing Recurrence of Crohn's Disease After Ileocolonic Surgery. Inflamm Bowel Dis. 2016 Oct; 22(10):2432-41.
  2. Leung DH, Grand RJ. 50 Years Ago in TheJournal ofPediatrics: Macroscopic Cysts of the Pancreas in a Case of Cystic Fibrosis. J Pediatr. 2016 Sep; 176:133.
  3. Baffour-Awuah NY, Fleet S, Montgomery RK, Baker SS, Butler JL, Campbell C, Tischfield S, Mitchell PD, Allende-Richter S, Moon JE, Fishman L, Bousvaros A, Fox V, Kuokkanen M, Grand RJ, Hirschhorn JN. Functional significance of single nucleotide polymorphisms in the lactase gene in diverse US patients and evidence for a novel lactase persistence allele at -13909 in those of European ancestry. J Pediatr Gastroenterol Nutr. 2015 Feb; 60(2):182-91.
  4. Lee JJ, Mitchell PD, Hood HC, Grand RJ, Cohen LE. Potential role of IGF-1 z score to predict permanent linear growth impairment in children with IBD. J Pediatr Gastroenterol Nutr. 2014 Apr; 58(4):472-6.
  5. Mrakotsky C, Forbes PW, Bernstein JH, Grand RJ, Bousvaros A, Szigethy E, Waber DP. Acute cognitive and behavioral effects of systemic corticosteroids in children treated for inflammatory bowel disease. J Int Neuropsychol Soc. 2013 Jan; 19(1):96-109.
  6. Burpee T, Mitchell P, Fishman D, Islam S, Nemeth E, Westerman M, Wessling-Resnick M, Grand RJ. Intestinal ferroportin expression in pediatric Crohn's disease. Inflamm Bowel Dis. 2011 Feb; 17(2):524-31.
  7. Lee JJ, Escher JC, Shuman MJ, Forbes PW, Delemarre LC, Harr BW, Kruijer M, Moret M, Allende-Richter S, Grand RJ. Final adult height of children with inflammatory bowel disease is predicted by parental height and patient minimum height Z-score. Inflamm Bowel Dis. 2010 Oct; 16(10):1669-77.
  8. Lee JJ, Essers JB, Kugathasan S, Escher JC, Lettre G, Butler JL, Stephens MC, Ramoni MF, Grand RJ, Hirschhorn J. Association of linear growth impairment in pediatric Crohn's disease and a known height locus: a pilot study. Ann Hum Genet. 2010 Nov; 74(6):489-97.
  9. Islam S, Loizides AM, Fialkovich JJ, Grand RJ, Montgomery RK. Developmental expression of Eph and ephrin family genes in mammalian small intestine. Dig Dis Sci. 2010 Sep; 55(9):2478-88.
  10. Lu Y, Jacobson DL, Ashworth LA, Grand RJ, Meyer AL, McNeal MM, Gregas MC, Burchett SK, Bousvaros A. Immune response to influenza vaccine in children with inflammatory bowel disease. Am J Gastroenterol. 2009 Feb; 104(2):444-53.
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  12. Shimwell NJ, Martin A, Bruton RK, Blackford AN, Sedgwick GG, Gallimore PH, Turnell AS, Grand RJ. Adenovirus 5 E1A is responsible for increased expression of insulin receptor substrate 4 in established adenovirus 5-transformed cell lines and interacts with IRS components activating the PI3 kinase/Akt signalling pathway. Oncogene. 2009 Feb 5; 28(5):686-97.
  13. Kappelman MD, Grand RJ. Does inflammatory bowel disease develop in infants? Inflamm Bowel Dis. 2008 Oct; 14 Suppl 2:S6-8.
  14. Peterson N, Guthery S, Denson L, Lee J, Saeed S, Prahalad S, Biank V, Ehlert R, Tomer G, Grand R, Rudolph C, Kugathasan S. Genetic variants in the autophagy pathway contribute to paediatric Crohn's disease. Gut. 2008 Sep; 57(9):1336-7; author reply 1337.
  15. Pappa HM, Bern E, Kamin D, Grand RJ. Vitamin D status in gastrointestinal and liver disease. Curr Opin Gastroenterol. 2008 Mar; 24(2):176-83.
  16. Grand RJ, Montgomery RK. Lactose malabsorption. Curr Treat Options Gastroenterol. 2008 Feb; 11(1):19-25.
  17. Montgomery RK, Krasinski SD, Hirschhorn JN, Grand RJ. Lactose and lactase--who is lactose intolerant and why? J Pediatr Gastroenterol Nutr. 2007 Dec; 45 Suppl 2:S131-7.
  18. Kappelman MD, Rifas-Shiman SL, Kleinman K, Ollendorf D, Bousvaros A, Grand RJ, Finkelstein JA. The prevalence and geographic distribution of Crohn's disease and ulcerative colitis in the United States. Clin Gastroenterol Hepatol. 2007 Dec; 5(12):1424-9.
  19. Kappelman MD, Bousvaros A, Hyams J, Markowitz J, Pfefferkorn M, Kugathasan S, Rosh J, Otley A, Mack D, Griffiths A, Evans J, Grand R, Langton C, Kleinman K, Finkelstein JA. Intercenter variation in initial management of children with Crohn's disease. Inflamm Bowel Dis. 2007 Jul; 13(7):890-5.
  20. Bruton RK, Rasti M, Mapp KL, Young N, Carter RZ, Abramowicz IA, Sedgwick GG, Onion DF, Shuen M, Mymryk JS, Turnell AS, Grand RJ. C-terminal-binding protein interacting protein binds directly to adenovirus early region 1A through its N-terminal region and conserved region 3. Oncogene. 2007 Nov 22; 26(53):7467-79.
  21. Richard Grand, MD, Christopher Duggan, MD, PhD, and Catherine Gordon, MD. Lactose Intolerance in Children. Pediatric Views. 2007; 3.
  22. Bosse T, Fialkovich JJ, Piaseckyj CM, Beuling E, Broekman H, Grand RJ, Montgomery RK, Krasinski SD. Gata4 and Hnf1alpha are partially required for the expression of specific intestinal genes during development. Am J Physiol Gastrointest Liver Physiol. 2007 May; 292(5):G1302-14.
  23. Pappa HM, Grand RJ, Gordon CM. Report on the vitamin D status of adult and pediatric patients with inflammatory bowel disease and its significance for bone health and disease. Inflamm Bowel Dis. 2006 Dec; 12(12):1162-74.
  24. Saeed SA, Integlia MJ, Pleskow RG, Calenda KA, Rohrer RJ, Dayal Y, Grand RJ. Tacrolimus-associated eosinophilic gastroenterocolitis in pediatric liver transplant recipients: role of potential food allergies in pathogenesis. Pediatr Transplant. 2006 Sep; 10(6):730-5.
  25. Bosse T, van Wering HM, Gielen M, Dowling LN, Fialkovich JJ, Piaseckyj CM, Gonzalez FJ, Akiyama TE, Montgomery RK, Grand RJ, Krasinski SD. Hepatocyte nuclear factor-1alpha is required for expression but dispensable for histone acetylation of the lactase-phlorizin hydrolase gene in vivo. Am J Physiol Gastrointest Liver Physiol. 2006 May; 290(5):G1016-24.
  26. Islam S, Montgomery RK, Fialkovich JJ, Grand RJ. Developmental and regional expression and localization of mRNAs encoding proteins involved in RNA translocation. J Histochem Cytochem. 2005 Dec; 53(12):1501-9.
  27. Hait E, Hait L, Bousvaros A, Grand R. Pediatric inflammatory bowel disease: what children can teach adults. Inflamm Bowel Dis. 2005 Jun; 11(6):519-27.
  28. Calenda KA, Schornagel IL, Sadeghi-Nejad A, Grand RJ. Effect of recombinant growth hormone treatment on children with Crohn's disease and short stature: a pilot study. Inflamm Bowel Dis. 2005 May; 11(5):435-41.
  29. Fiocchi C, Cucchiara S, Czinn SJ, Grand RJ, Levine AD, Seidman EG. Introduction: First International Symposium on: pediatric inflammatory bowel disease: September 16-18, 2003; Irvington, Virginia, U.S.A. J Pediatr Gastroenterol Nutr. 2005 Apr; 40 Suppl 1:S1.
  30. Grand RJ. Inverting the therapeutic triangle. J Pediatr Gastroenterol Nutr. 2005 Apr; 40 Suppl 1:S50-2.
  31. Griffiths AM, Otley AR, Hyams J, Quiros AR, Grand RJ, Bousvaros A, Feagan BG, Ferry GR. A review of activity indices and end points for clinical trials in children with Crohn's disease. Inflamm Bowel Dis. 2005 Feb; 11(2):185-96.
  32. Verhave M, Krasinski SD, Christian SI, Van Schaik S, Van Den Brink GR, Doting EM, Maas SM, Wolthers KC, Grand RJ, Montgomery RK. Regulatory regions in the rat lactase-phlorizin hydrolase gene that control cell-specific expression. J Pediatr Gastroenterol Nutr. 2004 Sep; 39(3):275-85.
  33. Pappa HM, Semrin G, Walker TR, Grand RJ. Pediatric inflammatory bowel disease. Curr Opin Gastroenterol. 2004 Jul; 20(4):333-40.
  34. van Wering HM, Bosse T, Musters A, de Jong E, de Jong N, Hogen Esch CE, Boudreau F, Swain GP, Dowling LN, Montgomery RK, Grand RJ, Krasinski SD. Complex regulation of the lactase-phlorizin hydrolase promoter by GATA-4. Am J Physiol Gastrointest Liver Physiol. 2004 Oct; 287(4):G899-909.
  35. Markowitz J, Rosh J, Hyams J, Bousvaros A, Del Rosario JF, Evans J, Grand RJ, Griffiths A, Katz A, Kugathasan S, Mack D, Mezoff A, Oliva-Hemker M, Pfefferkorn M, Rothbaum R, Tolia V, Treem W, Wyllie R, Hale S. Steriod Therapy in the Age of Infliximab (IFX): Intermediate & 1 Year Outcome in Newly Diagnosed Children with Crohn's Disease (CD): Experience of the Pediatric IBD Collaborative Research Group. Gastroenterology. 2004; 364:W-1394.
  36. Islam S, MOntgomery RK, Grand RJ. Developmental Expression of mRNAs Encoding Proteins Involved in RNA Translocation. Gastroenterology. 2004; 364:M-969.
  37. Miller LC, Kelly N, Tannemaat M, Grand RJ. Serologic prevalence of antibodies to Helicobacter pylori in internationally adopted children. Helicobacter. 2003 Jun; 8(3):173-8.
  38. Grand RJ, Montgomery RK, Chitkara DK, Hirschhorn JN. Changing genes; losing lactase. Gut. 2003 May; 52(5):617-9.
  39. Escher JC, Taminiau JA, Nieuwenhuis EE, Büller HA, Grand RJ. Treatment of inflammatory bowel disease in childhood: best available evidence. Inflamm Bowel Dis. 2003 Jan; 9(1):34-58.
  40. Krasinski SD, Gielen M, Dowling LN, Bosse T, van Wering HM, Akiyama TE, Gonzalez FJ, Montgomery RK, Grand RJ. Hepatocyte nuclear factor-1a (HNF-1a) differentially regulates lactase-phlorizin hydrolase (LPH) gene expression during weaning in mice. Gastroenterology. 2003; 124:A-91.
  41. Houle VM, Li W, Montgomery RK, Grand RJ. mRNA localization in polarized intestinal epithelial cells. Am J Physiol Gastrointest Liver Physiol. 2003 Apr; 284(4):G722-7.
  42. Rothbaum R, Perrault J, Vlachos A, Cipolli M, Alter BP, Burroughs S, Durie P, Elghetany MT, Grand R, Hubbard V, Rommens J, Rossi T. Shwachman-Diamond syndrome: report from an international conference. J Pediatr. 2002 Aug; 141(2):266-70.
  43. van Wering HM, Huibregtse IL, van der Zwan SM, de Bie MS, Dowling LN, Boudreau F, Rings EH, Grand RJ, Krasinski SD. Physical interaction between GATA-5 and hepatocyte nuclear factor-1alpha results in synergistic activation of the human lactase-phlorizin hydrolase promoter. J Biol Chem. 2002 Aug 2; 277(31):27659-67.
  44. Verhave M, Baldassano RN, Bousvaros A, Grand RJ, Kirschner BS. Research agenda for pediatric gastroenterology, hepatology and nutrition: chronic inflammatory bowel disease. Report of the North American Society for Pediatric Gastroenterology, Hepatology and Nutrition for the Children's Digestive Health and Nutrition Foundation. J Pediatr Gastroenterol Nutr. 2002; 35 Suppl 3:S286-90.
  45. Sherman PM, Grand RJ. Research agenda for pediatric gastroenterology, hepatology and nutrition: introduction. Report of the North American Society for Pediatric Gastroenterology, Hepatology and Nutrition for the Children's Digestive Health and Nutrition Foundation. J Pediatr Gastroenterol Nutr. 2002; 35 Suppl 3:S235-6.
  46. Martín MG, Silveira TR, Grand R, Greco L, Matsui A, Shimizu N, Turck D. Genetics of gastrointestinal and hepatobiliary disorders: Working Group Report of the First World Congress of Pediatric Gastroenterology, Hepatology, and Nutrition. J Pediatr Gastroenterol Nutr. 2002; 35 Suppl 2:S118-27.
  47. Krasinski SD, van Wering HM, de Jong N, Dowling L, Grand RJ. Friend of GATA (FOG) cofactors modulate the GATA activation of the human lactase-phlorizin hydrolase (LPH) promoter. Gastroenterology. 2002; 122:A-680.
  48. Grand RJ. Section Editor's Commentary. Anti-TNF Therapies Have Eliminated the Need for Steroids in Pediatric Crohn's Disease. Inflamm Bowel Dis. 2001 Nov; 7(4):345-346.
  49. Chen J, Huber BT, Grand RJ, Li W. Recombinant adenovirus coexpressing covalent peptide/MHC class II complex and B7-1: in vitro and in vivo activation of myelin basic protein-specific T cells. J Immunol. 2001 Aug 1; 167(3):1297-305.
  50. Kaplan SH, Greenfield S, Connolly GA, Barlow SE, Grand R. Methodologic issues in the conduct and interpretation of pediatric effectiveness research. Ambul Pediatr. 2001 Jan-Feb; 1(1):63-70.
  51. Molloy DP, Barral PM, Bremner KH, Gallimore PH, Grand RJ. Structural determinants in adenovirus 12 E1A involved in the interaction with C-terminal binding protein 1. Virology. 2000 Nov 10; 277(1):156-66.
  52. Turnell AS, Grand RJ, Gorbea C, Zhang X, Wang W, Mymryk JS, Gallimore PH. Regulation of the 26S proteasome by adenovirus E1A. EMBO J. 2000 Sep 1; 19(17):4759-73.
  53. Hutton FG, Turnell AS, Gallimore PH, Grand RJ. Consequences of disruption of the interaction between p53 and the larger adenovirus early region 1B protein in adenovirus E1 transformed human cells. Oncogene. 2000 Jan 20; 19(3):452-62.
  54. Li W, Wang J, Coluccio LM, Matsudaira P, Grand RJ. Brush border myosin I (BBMI): a basally localized transcript in human jejunal enterocytes. J Histochem Cytochem. 2000 Jan; 48(1):89-94.
  55. Grand RJ, Li W, Montgomery RK, Büller HA. Gene therapy for gastrointestinal disorders: just around the corner? J Pediatr Gastroenterol Nutr. 1999 Oct; 29(4):375-6.
  56. Shashidhar H, Langhans N, Grand RJ. Propranolol in prevention of portal hypertensive hemorrhage in children: a pilot study. J Pediatr Gastroenterol Nutr. 1999 Jul; 29(1):12-7.
  57. Schmeiser K, Grand RJ. The fate of E- and P-cadherin during the early stages of apoptosis. Cell Death Differ. 1999 Apr; 6(4):377-86.
  58. Turnell AS, Grand RJ, Gallimore PH. The replicative capacities of large E1B-null group A and group C adenoviruses are independent of host cell p53 status. J Virol. 1999 Mar; 73(3):2074-83.
  59. Montgomery RK, Mulberg AE, Grand RJ. Development of the human gastrointestinal tract: twenty years of progress. Gastroenterology. 1999 Mar; 116(3):702-31.
  60. Molloy DP, Smith KJ, Milner AE, Gallimore PH, Grand RJ. The structure of the site on adenovirus early region 1A responsible for binding to TATA-binding protein determined by NMR spectroscopy. J Biol Chem. 1999 Feb 5; 274(6):3503-12.
  61. Grand RJ, Parkhill J, Szestak T, Rookes SM, Roberts S, Gallimore PH. Definition of a major p53 binding site on Ad2E1B58K protein and a possible nuclear localization signal on the Ad12E1B54K protein. Oncogene. 1999 Jan 28; 18(4):955-65.
  62. Grand RJ, Turnell AS, Mason GG, Wang W, Milner AE, Mymryk JS, Rookes SM, Rivett AJ, Gallimore PH. Adenovirus early region 1A protein binds to mammalian SUG1-a regulatory component of the proteasome. Oncogene. 1999 Jan 14; 18(2):449-58.
  63. Unit 35: Development of the Human GI System. 1999.
  64. Molloy DP, Milner AE, Yakub IK, Chinnadurai G, Gallimore PH, Grand RJ. Structural determinants present in the C-terminal binding protein binding site of adenovirus early region 1A proteins. J Biol Chem. 1998 Aug 14; 273(33):20867-76.
  65. Schmeiser K, Hammond EM, Roberts S, Grand RJ. Specific cleavage of gamma catenin by caspases during apoptosis. FEBS Lett. 1998 Aug 14; 433(1-2):51-7.
  66. Estrada G, Krasinski SD, Grand RJ, López-Tejero MD. Defective intracellular processing of lactase-phlorizin hydrolase protein in rats prenatally exposed to ethanol. Alcohol Clin Exp Res. 1998 Aug; 22(5):1177-83.
  67. Grand RJ. Management of severe colitis/ileocolitis. Inflamm Bowel Dis. 1998 Aug; 4(3):225-7.
  68. Grand RJ, Ibrahim AP, Taylor AM, Milner AE, Gregory CD, Gallimore PH, Turnell AS. Human cells arrest in S phase in response to adenovirus 12 E1A. Virology. 1998 May 10; 244(2):330-42.
  69. Grand RJ, Gash L, Milner AE, Molloy DP, Szestak T, Turnell AS, Gallimore PH. Regeneration of the binding properties of adenovirus 12 early region 1A proteins after preparation under denaturing conditions. Virology. 1998 Apr 25; 244(1):230-42.
  70. Grand RJ. The Shwachman Award of the North American Society for Pediatric Gastroenterology and Nutrition presentation. J Pediatr Gastroenterol Nutr. 1998 Apr; 26(4):371-5.
  71. Barth JA, Li W, Krasinski SD, Montgomery RK, Verhave M, Grand RJ. Asymmetrical localization of mRNAs in enterocytes of human jejunum. J Histochem Cytochem. 1998 Mar; 46(3):335-43.
  72. Grand RJ. Treatment of extraintestinal manifestations of inflammatory bowel disease. Inflamm Bowel Dis. 1998 Feb; 4(1):72; discussion 73.
  73. Klein S, Alpers DH, Grand RJ, Levin MS, Lin HC, Mansbach CM, Burant C, Reeds P, Rombeau JL. Advances in nutrition and gastroenterology: summary of the 1997 A.S.P.E.N. Research Workshop. JPEN J Parenter Enteral Nutr. 1998 Jan-Feb; 22(1):3-13.
  74. Krishnamurthy S, Integlia MJ, Grand RJ, Dayal Y. Pancreatic acinar cell clusters in pediatric gastric mucosa. Am J Surg Pathol. 1998 Jan; 22(1):100-5.
  75. Milner AE, Grand RJ, Vaughan AT, Armitage RJ, Gregory CD. Differential effects of BCL-2 on survival and proliferation of human B-lymphoma cells following gamma-irradiation. Oncogene. 1997 Oct 9; 15(15):1815-22.
  76. Krasinski SD, Upchurch BH, Irons SJ, June RM, Mishra K, Grand RJ, Verhave M. Rat lactase-phlorizin hydrolase/human growth hormone transgene is expressed on small intestinal villi in transgenic mice. Gastroenterology. 1997 Sep; 113(3):844-55.
  77. Gallimore PH, Lecane PS, Roberts S, Rookes SM, Grand RJ, Parkhill J. Adenovirus type 12 early region 1B 54K protein significantly extends the life span of normal mammalian cells in culture. J Virol. 1997 Sep; 71(9):6629-40.
  78. Gallimore PH, Lecane PS, Hann B, Grand RJ. Differentiation is inhibited and a senescence pathway is activated when simian virus 40 tsA 58-transformed human retinoblasts are grown at the restrictive temperature. Cell Growth Differ. 1997 Jul; 8(7):763-71.
  79. FitzSimmons SC, Burkhart GA, Borowitz D, Grand RJ, Hammerstrom T, Durie PR, Lloyd-Still JD, Lowenfels AB. High-dose pancreatic-enzyme supplements and fibrosing colonopathy in children with cystic fibrosis. N Engl J Med. 1997 May 1; 336(18):1283-9.
  80. Montgomery RK, Rings EH, Thompson JF, Schuijt CC, Aras KM, Wielenga VJ, Kothe MJ, Büller HA, Grand RJ. Increased C/EBP in fetal rat small intestine precedes initiation of differentiation marker mRNA synthesis. Am J Physiol. 1997 Mar; 272(3 Pt 1):G534-44.
  81. Estrada G, Krasinski SD, Rings EH, Büller HA, Grand RJ, López-Tejero MD. Prenatal ethanol exposure alters the expression of intestinal hydrolase mRNAs in newborn rats. Alcohol Clin Exp Res. 1996 Dec; 20(9):1662-8.
  82. Weisselberg B, Dayal Y, Thompson JF, Doyle MS, Senior B, Grand RJ. A lamb-meat-based formula for infants allergic to casein hydrolysate formulas. Clin Pediatr (Phila). 1996 Oct; 35(10):491-5.
  83. Grand RJ, Ramakrishna J, Calenda KA. Therapeutic strategies for pediatric Crohn disease. Clin Invest Med. 1996 Oct; 19(5):373-80.
  84. Wang H, Grand RJ, Milner AE, Armitage RJ, Gordon J, Gregory CD. Repression of apoptosis in human B-lymphoma cells by CD40-ligand and Bcl-2: relationship to the cell-cycle and role of the retinoblastoma protein. Oncogene. 1996 Jul 18; 13(2):373-9.
  85. Estrada G, Krasinski SD, Montgomery RK, Grand RJ, García-Valero J, López-Tejero MD. Quantitative analysis of lactase-phlorizin hydrolase expression in the absorptive enterocytes of newborn rat small intestine. J Cell Physiol. 1996 May; 167(2):341-8.
  86. Ramakrishna J, Langhans N, Calenda K, Grand RJ, Verhave M. Combined use of cyclosporine and azathioprine or 6-mercaptopurine in pediatric inflammatory bowel disease. J Pediatr Gastroenterol Nutr. 1996 Apr; 22(3):296-302.
  87. Grand RJ, Owen D, Rookes SM, Gallimore PH. Control of p53 expression by adenovirus 12 early region 1A and early region 1B 54K proteins. Virology. 1996 Apr 1; 218(1):23-34.
  88. Grand RJ, Turnell AS, Grabham PW. Cellular consequences of thrombin-receptor activation. Biochem J. 1996 Jan 15; 313 ( Pt 2):353-68.
  89. Winter H, Grand R. Medical therapy for children with inflammatory bowel disease. Inflamm Bowel Dis. 1996; 2(4):269-75.
  90. Borowitz DS, Grand RJ, Durie PR. Use of pancreatic enzyme supplements for patients with cystic fibrosis in the context of fibrosing colonopathy. Consensus Committee. J Pediatr. 1995 Nov; 127(5):681-4.
  91. Neele AM, Einerhand AW, Dekker J, Büller HA, Freund JN, Verhave M, Grand RJ, Montgomery RK. Verification of the lactase site of rat lactase-phlorizin hydrolase by site-directed mutagenesis. Gastroenterology. 1995 Oct; 109(4):1234-40.
  92. Grand RJ, Ramakrishna J, Calenda KA. Inflammatory bowel disease in the pediatric patient. Gastroenterol Clin North Am. 1995 Sep; 24(3):613-32.
  93. Molloy DP, Owen D, Grand RJ. Ras binding to a C-terminal region of GAP. FEBS Lett. 1995 Jul 17; 368(2):297-303.
  94. Turnell AS, Brant DP, Brown GR, Finney M, Gallimore PH, Kirk CJ, Pagliuca TR, Campbell CJ, Michell RH, Grand RJ. Regulation of neurite outgrowth from differentiated human neuroepithelial cells: a comparison of the activities of prothrombin and thrombin. Biochem J. 1995 Jun 15; 308 ( Pt 3):965-73.
  95. Grand RJ, Milner AE, Mustoe T, Johnson GD, Owen D, Grant ML, Gregory CD. A novel protein expressed in mammalian cells undergoing apoptosis. Exp Cell Res. 1995 Jun; 218(2):439-51.
  96. Verhave M, Krasinski SD, Maas SM, Smiers FJ, Mishra K, Breeuwsma NG, Naim HY, Grand RJ. Further characterization of the 5'-flanking region of the rat lactase-phlorizin hydrolase gene. Biochem Biophys Res Commun. 1995 Apr 26; 209(3):989-95.
  97. Grand RJ, Mustoe T, Roberts S, Gallimore PH. The quaternary structure of the adenovirus 12 early region 1B 54K protein. Virology. 1995 Feb 20; 207(1):255-9.
  98. Van Beers EH, Büller HA, Grand RJ, Einerhand AW, Dekker J. Intestinal brush border glycohydrolases: structure, function, and development. Crit Rev Biochem Mol Biol. 1995; 30(3):197-262.
  99. Rings EH, Grand RJ, Büller HA. Lactose intolerance and lactase deficiency in children. Curr Opin Pediatr. 1994 Oct; 6(5):562-7.
  100. Krasinski SD, Estrada G, Yeh KY, Yeh M, Traber PG, Rings EH, Büller HA, Verhave M, Montgomery RK, Grand RJ. Transcriptional regulation of intestinal hydrolase biosynthesis during postnatal development in rats. Am J Physiol. 1994 Oct; 267(4 Pt 1):G584-94.
  101. Grand RJ, Grant ML, Gallimore PH. Enhanced expression of p53 in human cells infected with mutant adenoviruses. Virology. 1994 Sep; 203(2):229-40.
  102. Ramakrishna J, Grand RJ. Gene therapy for exocrine pancreatic insufficiency. Gastroenterology. 1994 Jun; 106(6):1711-3.
  103. Smith KJ, Trayer IP, Grand RJ. Structure around the cleavage site in the thrombin receptor determined by NMR spectroscopy. Biochemistry. 1994 May 24; 33(20):6063-73.
  104. Rings EH, Krasinski SD, van Beers EH, Moorman AF, Dekker J, Montgomery RK, Grand RJ, Büller HA. Restriction of lactase gene expression along the proximal-to-distal axis of rat small intestine occurs during postnatal development. Gastroenterology. 1994 May; 106(5):1223-32.
  105. Lentze MJ, Naim HY, and Grand RJ. Mammalian Brush Border Membrane Proteins II. 1994.
  106. Motil KJ, Grand RJ, Davis-Kraft L, Ferlic LL, Smith EO. Growth failure in children with inflammatory bowel disease: a prospective study. Gastroenterology. 1993 Sep; 105(3):681-91.
  107. Keane NE, Molloy DP, Grand RJ, Owen D, Levine BA, Ellis L. Peptide mimetics of nucleotide phosphate binding sites. Biochem Soc Trans. 1993 Aug; 21 ( Pt 3)(3):267S.
  108. Ferry GD, Kirschner BS, Grand RJ, Issenman RM, Griffiths AM, Vanderhoof JA, Fiedorek SC, Winter HS, Hassall EG, Watkins JB, et al. Olsalazine versus sulfasalazine in mild to moderate childhood ulcerative colitis: results of the Pediatric Gastroenterology Collaborative Research Group Clinical Trial. J Pediatr Gastroenterol Nutr. 1993 Jul; 17(1):32-8.
  109. Grand RJ, Lecane PS, Roberts S, Grant ML, Lane DP, Young LS, Dawson CW, Gallimore PH. Overexpression of wild-type p53 and c-Myc in human fetal cells transformed with adenovirus early region 1. Virology. 1993 Apr; 193(2):579-91.
  110. Mulberg AE, Linz C, Bern E, Tucker L, Verhave M, Grand RJ. Identification of nonsteroidal antiinflammatory drug-induced gastroduodenal injury in children with juvenile rheumatoid arthritis. J Pediatr. 1993 Apr; 122(4):647-9.
  111. Rings EH, de Boer PA, Moorman AF, van Beers EH, Dekker J, Montgomery RK, Grand RJ, Büller HA. Lactase gene expression during early development of rat small intestine. Gastroenterology. 1992 Oct; 103(4):1154-61.
  112. Montgomery RK, Grand RJ. Developmental regulation of the brush border hydrolase lactase. J Pediatr Gastroenterol Nutr. 1992 Aug; 15(2):215-7.
  113. Kowdley KV, Mason JB, Meydani SN, Cornwall S, Grand RJ. Vitamin E deficiency and impaired cellular immunity related to intestinal fat malabsorption. Gastroenterology. 1992 Jun; 102(6):2139-42.
  114. Rings EH, Büller HA, de Boer PA, Grand RJ, Montgomery RK, Lamers WH, Charles R, Moorman AF. Messenger RNA sorting in enterocytes. Co-localization with encoded proteins. FEBS Lett. 1992 Mar 30; 300(2):183-7.
  115. Lambert J, Mobassaleh M, Grand RJ. Efficacy of cimetidine for gastric acid suppression in pediatric patients. J Pediatr. 1992 Mar; 120(3):474-8.
  116. Escher JC, de Koning ND, van Engen CG, Arora S, Büller HA, Montgomery RK, Grand RJ. Molecular basis of lactase levels in adult humans. J Clin Invest. 1992 Feb; 89(2):480-3.
  117. Davies AH, Grand RJ, Evans FJ, Rickinson AB. Induction of Epstein-Barr virus lytic cycle by tumor-promoting and non-tumor-promoting phorbol esters requires active protein kinase C. J Virol. 1991 Dec; 65(12):6838-44.
  118. Grand RJ, Owen D. The biochemistry of ras p21. Biochem J. 1991 Nov 1; 279 ( Pt 3):609-31.
  119. Yeh KY, Yeh M, Montgomery RK, Grand RJ, Holt PR. Cortisone and thyroxine modulate intestinal lactase and sucrase mRNA levels and activities in the suckling rat. Biochem Biophys Res Commun. 1991 Oct 15; 180(1):174-80.
  120. Pleskow RG, Berhane V, Grand RJ. Gastrointestinal Disorders in Adolescents. Adolesc Med. 1991 Oct; 2(3):485-498.
  121. Jackson WD, Grand RJ. The human intestinal response to enteral nutrients: a review. J Am Coll Nutr. 1991 Oct; 10(5):500-9.
  122. Montgomery RK, Büller HA, Rings EH, Grand RJ. Lactose intolerance and the genetic regulation of intestinal lactase-phlorizin hydrolase. FASEB J. 1991 Oct; 5(13):2824-32.
  123. Stevens C, Peppercorn MA, Grand RJ. Crohn's disease associated with autoimmune neutropenia. J Clin Gastroenterol. 1991 Jun; 13(3):328-30.
  124. van 't Hoff BW, Rings EH, Grand RJ, Büller HA. [Lactose intolerance. II. Current biological viewpoints]. Ned Tijdschr Geneeskd. 1991 Apr 27; 135(17):746-9.
  125. Rings EH, van 't Hoff BW, Grand RJ, Büller HA. [Lactose intolerance. I. Clinical aspects, diagnosis and therapy]. Ned Tijdschr Geneeskd. 1991 Apr 27; 135(17):742-6.
  126. Merrick RM, Grand RJ, Brown JC, Gallimore PH. The use of beta-galactosidase fusion proteins encoding the early region 1 transforming proteins of adenovirus type 12 to examine the humoral response in tumour-bearing animals. J Gen Virol. 1991 Apr; 72 ( Pt 4):955-60.
  127. Büller HA, Rings EH, Montgomery RK, Grand RJ. Clinical aspects of lactose intolerance in children and adults. Scand J Gastroenterol Suppl. 1991; 188:73-80.
  128. Verhave M, Winter HS, Grand RJ. Azathioprine in the treatment of children with inflammatory bowel disease. J Pediatr. 1990 Nov; 117(5):809-14.
  129. Grant ML, Bruton RK, Byrd PJ, Gallimore PH, Steele JC, Taylor AM, Grand RJ. Sensitivity to ionising radiation of transformed human cells containing mutant ras genes. Oncogene. 1990 Aug; 5(8):1159-64.
  130. Mitchison HM, Grand RJ, Byrd PJ, Johnson GD, Parton A, Gallimore PH. The expression of the adenovirus 12 early region 1B 19K protein using a recombinant simian virus 40 system. J Gen Virol. 1990 Aug; 71 ( Pt 8):1713-22.
  131. Büller HA, Kothe MJ, Goldman DA, Grubman SA, Sasak WV, Matsudaira PT, Montgomery RK, Grand RJ. Coordinate expression of lactase-phlorizin hydrolase mRNA and enzyme levels in rat intestine during development. J Biol Chem. 1990 Apr 25; 265(12):6978-83.
  132. Parton A, Grand RJ, Biggs P, Settleman J, DiMaio D, Gallimore PH. Integrated HPV 1 genomes in a human keratinocyte cell line can be transactivated by a SV40/BPV1 recombinant virus which expresses BPV1 E2 proteins. Virology. 1990 Apr; 175(2):508-17.
  133. Büller HA, Rings EH, Pajkrt D, Montgomery RK, Grand RJ. Glycosylation of lactase-phlorizin hydrolase in rat small intestine during development. Gastroenterology. 1990 Mar; 98(3):667-75.
  134. Büller HA, Grand RJ. Lactose intolerance. Annu Rev Med. 1990; 41:141-8.
  135. Grand RJ, Byrd PJ, Grabham PW, Gregory CD, Huen DS, Merrick RM, Young LS, Gallimore PH. The expression of the retinoblastoma gene product Rb1 in primary and adenovirus-transformed human cells. Oncogene. 1989 Nov; 4(11):1291-8.
  136. Büller HA, Rings EH, Montgomery RK, Sasak WV, Grand RJ. Further studies of glycosylation and intracellular transport of lactase-phlorizin hydrolase in rat small intestine. Biochem J. 1989 Oct 1; 263(1):249-54.
  137. Büller HA, Van Wassenaer AG, Raghavan S, Montgomery RK, Sybicki MA, Grand RJ. New insights into lactase and glycosylceramidase activities of rat lactase-phlorizin hydrolase. Am J Physiol. 1989 Oct; 257(4 Pt 1):G616-23.
  138. Büller HA, Rings EH, Montgomery RK, Sybicki MA, Grand RJ. Suckling rat colon synthesizes and processes active lactase-phlorizin hydrolase immunologically identical to that from jejunum. Pediatr Res. 1989 Sep; 26(3):232-6.
  139. Grand RJ, Grant ML. Conformational changes occurring in N-ras p21 in response to binding of guanine nucleotide and metal ions probed by proteolysis performed under controlled conditions. FEBS Lett. 1989 Aug 14; 253(1-2):281-6.
  140. Grand RJ, Grabham PW, Gallimore MJ, Gallimore PH. Modulation of morphological differentiation of human neuroepithelial cells by serine proteases: independence from blood coagulation. EMBO J. 1989 Aug; 8(8):2209-15.
  141. Grand RJ, Doorbar J, Smith KJ, Coneron I, Gallimore PH. Phosphorylation of the human papillomavirus type 1 E4 proteins in vivo and in vitro. Virology. 1989 May; 170(1):201-13.
  142. Smith KJ, Gallimore PH, Grand RJ. The expression of Ad12 E1B 19K protein on the surface of adenovirus transformed and infected human cells. Oncogene. 1989 Apr; 4(4):489-97.
  143. Grand RJ. Acylation of viral and eukaryotic proteins. Biochem J. 1989 Mar 15; 258(3):625-38.
  144. Grand RJ, Levine BA, Byrd PJ, Gallimore PH. The binding of guanine nucleotide to N-ras p21--a phosphorous and proton magnetic resonance study. Oncogene. 1989 Mar; 4(3):355-61.
  145. Grabham PW, Grand RJ, Gallimore PH. Purification of a serum factor which reverses dibutyryl cAMP induced differentiation. Cell Signal. 1989; 1(3):269-81.
  146. Huen DS, Grand RJ, Young LS. A region of the Epstein-Barr virus nuclear antigen leader protein and adenovirus E1A are identical. Oncogene. 1988 Dec; 3(6):729-30.
  147. Grand RJ. Intracellular calcium receptor mechanisms in muscle and nerve. Biochem Soc Trans. 1988 Aug; 16(4):520-3.
  148. Grabham PW, Grand RJ, Byrd PJ, Gallimore PH. Differentiation of normal and adenovirus-12 E1 transformed human embryo retinal cells. Exp Eye Res. 1988 Jul; 47(1):123-33.
  149. Mobassaleh M, Donohue-Rolfe A, Jacewicz M, Grand RJ, Keusch GT. Pathogenesis of shigella diarrhea: evidence for a developmentally regulated glycolipid receptor for shigella toxin involved in the fluid secretory response of rabbit small intestine. J Infect Dis. 1988 May; 157(5):1023-31.
  150. Byrd PJ, Grand RJ, Gallimore PH. Differential transformation of primary human embryo retinal cells by adenovirus E1 regions and combinations of E1A + ras. Oncogene. 1988 May; 2(5):477-84.
  151. Byrd PJ, Grand RJ, Breiding D, Williams JF, Gallimore PH. Host range mutants of adenovirus type 12 E1 defective for lytic infection, transformation, and oncogenicity. Virology. 1988 Mar; 163(1):155-65.
  152. Jaros W, Biller J, Greer S, O'Dorisio T, Grand R. Successful treatment of idiopathic secretory diarrhea of infancy with the somatostatin analogue SMS 201-995. Gastroenterology. 1988 Jan; 94(1):189-93.
  153. Büller HA, Montgomery RK, Sasak WV, Grand RJ. Biosynthesis, glycosylation, and intracellular transport of intestinal lactase-phlorizin hydrolase in rat. J Biol Chem. 1987 Dec 15; 262(35):17206-11.
  154. Motil KJ, Grand RJ. Ulcerative colitis and Crohn disease in children. Pediatr Rev. 1987 Oct; 9(4):109-20.
  155. Biller JA, Grand RJ, Harris BH. Abdominal abscesses in adolescents with Crohn's disease. J Pediatr Surg. 1987 Sep; 22(9):873-6.
  156. Grand RJ, Smith KJ, Gallimore PH. Evidence for the expression of protein IX in some rat cells transformed with adenovirus type 12 early region 1 DNA. J Gen Virol. 1987 Sep; 68 ( Pt 9):2471-6.
  157. Grand RJ, Rowe M, Byrd PJ, Gallimore PH. The level of expression of class-I MHC antigens in adenovirus-transformed human cell lines. Int J Cancer. 1987 Aug 15; 40(2):213-9.
  158. Schoch DR, Sullivan AL, Grand RJ, Eagan WF. Gastrointestinal bleeding in an adolescent runner. J Pediatr. 1987 Aug; 111(2):302-4.
  159. Vacanti JP, Lillehei CW, Jenkins RL, Donahoe PK, Cosimi AB, Kleinman R, Grand RJ, Cho SI. Liver transplantation in children: the Boston Center experience in the first 30 months. Transplant Proc. 1987 Aug; 19(4):3261-6.
  160. Biller JA, King S, Rosenthal A, Grand RJ. Efficacy of lactase-treated milk for lactose-intolerant pediatric patients. J Pediatr. 1987 Jul; 111(1):91-4.
  161. Stoler J, Biller JA, Grand RJ. Pancreatitis in Kawasaki disease. Am J Dis Child. 1987 Mar; 141(3):306-8.
  162. Klein JD, Biller JA, Leape LL, Grand RJ. Pyoderma gangrenosum occurring at multiple surgical incision sites. Gastroenterology. 1987 Mar; 92(3):810-3.
  163. Herzog LW, Bithoney WG, Grand RJ. High sodium rehydration solutions in well-nourished outpatients. Acta Paediatr Scand. 1987 Mar; 76(2):306-10.
  164. Wilson SE, Dietz WH, Grand RJ. An algorithm for pediatric enteral alimentation. Pediatr Ann. 1987 Mar; 16(3):233-4, 236-40.
  165. Armstrong MJ, Montgomery RK, Perez A, Grand RJ. Dolichol content and isoprenolog distribution in developing rat small intestine. Pediatr Res. 1987 Mar; 21(3):261-5.
  166. Perlmutter DH, Gross P, Jones HR, Fulton A, Grand RJ. Intramuscular vitamin E repletion in children with chronic cholestasis. Am J Dis Child. 1987 Feb; 141(2):170-4.
  167. Grand RJ, Smith KJ, Gallimore PH. Purification and characterisation of the protein encoded by the activated human N-ras gene and its membrane localisation. Oncogene. 1987; 1(3):305-14.
  168. Grand RJ. The structure and functions of the adenovirus early region 1 proteins. Biochem J. 1987 Jan 1; 241(1):25-38.
  169. Biller JA, Montgomery RK, Grand RJ, Klagsbrun M, Rosenthal A. Characterisation of humoral trophic factors involved in intestinal adaptation using a 3T3 cell growth factor assay. Gut. 1987; 28 Suppl:243-7.
  170. Grand RJ, Sutphen JL, and Dietz WH . Pediatric Nutrition. 1987.
  171. Fuchs G, Mobassaleh M, Donohue-Rolfe A, Montgomery RK, Grand RJ, Keusch GT. Pathogenesis of Shigella diarrhea: rabbit intestinal cell microvillus membrane binding site for Shigella toxin. Infect Immun. 1986 Aug; 53(2):372-7.
  172. Biller JA, Montgomery RK, Grand RJ, Klagsbrun M, Rosenthal A. Use of a 3T3 cell growth factor assay for the delineation and characterization of humoral trophic factors involved in intestinal adaptation in the rat. Gastroenterology. 1986 Aug; 91(2):448-55.
  173. Doorbar J, Campbell D, Grand RJ, Gallimore PH. Identification of the human papilloma virus-1a E4 gene products. EMBO J. 1986 Feb; 5(2):355-62.
  174. Motil KJ, Altchuler SI, Grand RJ. Mineral balance during nutritional supplementation in adolescents with Crohn disease and growth failure. J Pediatr. 1985 Sep; 107(3):473-9.
  175. Jonas MM, Montgomery RK, Grand RJ. Intestinal lactase synthesis during postnatal development in the rat. Pediatr Res. 1985 Sep; 19(9):956-62.
  176. Motil KJ, Grand RJ. Nutritional management of inflammatory bowel disease. Pediatr Clin North Am. 1985 Apr; 32(2):447-69.
  177. Grand RJ, Roberts C, Gallimore PH. Acylation of adenovirus type 12 early region 1b 18-kDa protein. Further evidence for its localisation in the cell membrane. FEBS Lett. 1985 Feb 25; 181(2):229-35.
  178. Grand RJ, Montgomery RK, Perez A. Synthesis and intracellular processing of sucrase-isomaltase in rat jejunum. Gastroenterology. 1985 Feb; 88(2):531-8.
  179. Mobassaleh M, Montgomery RK, Biller JA, Grand RJ. Development of carbohydrate absorption in the fetus and neonate. Pediatrics. 1985 Jan; 75(1 Pt 2):160-6.
  180. Lefebvre MP, Leape LL, Pohl DA, Safaii H, Grand RJ. Total colonic aganglionosis initially diagnosed in an adolescent. Gastroenterology. 1984 Dec; 87(6):1364-6.
  181. Grand RJ, Gallimore PH. Adenovirus type 12 early region 1 proteins: a study of their subcellular localization and protein-protein interactions. J Gen Virol. 1984 Dec; 65 ( Pt 12):2149-66.
  182. Schwarz KB, Burris GC, deMello DE, Hyams JS, Biller JA, Maksimak MG, Winter HS, Grand RJ. Prolonged elevation of transaminase concentration in children with unsuspected myopathy. Am J Dis Child. 1984 Dec; 138(12):1121-4.
  183. Nairn AC, Grand RJ, Perry SV. The amino acid sequence of rabbit skeletal muscle calmodulin. FEBS Lett. 1984 Feb 27; 167(2):215-20.
  184. Grand RJ. [Small intestine biopsy in the diagnosis of intestinal diseases]. Bol Med Hosp Infant Mex. 1983 Nov; 40(11):593-4.
  185. Biller JA, Winter HS, Grand RJ, Allred EN. Are endoscopic changes predictive of histologic esophagitis in children? J Pediatr. 1983 Aug; 103(2):215-8.
  186. Spivak W, Grand RJ. General configuration of cholestasis in the newborn. J Pediatr Gastroenterol Nutr. 1983 May; 2(2):381-92.
  187. Sutphen JL, Grand RJ, Flores A, Chang TW, Bartlett JG. Chronic diarrhea associated with Clostridium difficile in children. Am J Dis Child. 1983 Mar; 137(3):275-8.
  188. Moir AJ, Ordidge M, Grand RJ, Trayer IP, Perry SV. Studies of the interaction of troponin I with proteins of the I-filament and calmodulin. Biochem J. 1983 Feb 1; 209(2):417-26.
  189. Winter HS, Madara JL, Stafford RJ, Grand RJ, Quinlan JE, Goldman H. Intraepithelial eosinophils: a new diagnostic criterion for reflux esophagitis. Gastroenterology. 1982 Oct; 83(4):818-23.
  190. Motil KJ, Grand RJ, Maletskos CJ, Young VR. The effect of disease, drug, and diet on whole body protein metabolism in adolescents with Crohn disease and growth failure. J Pediatr. 1982 Sep; 101(3):345-51.
  191. Hyams JS, Grand RJ, Colodny AH, Schuster SR, Eraklis A. Course and prognosis after colectomy and ileostomy for inflammatory bowel disease in childhood and adolescence. J Pediatr Surg. 1982 Aug; 17(4):400-5.
  192. Motil KJ, Grand RJ, Matthews DE, Bier DM, Maletskos CJ, Young VR. Whole body leucine metabolism in adolescents with Crohn's disease and growth failure during nutritional supplementation. Gastroenterology. 1982 Jun; 82(6):1359-68.
  193. Grand RJ, Levine BA, Perry SV. Proton-magnetic-resonance studies on the interaction of rabbit skeletal-muscle troponin I with troponin C and actin. Biochem J. 1982 Apr 1; 203(1):61-8.
  194. Hyams JS, Batrus CL, Grand RJ, Sallan SE. Cancer chemotherapy-induced lactose malabsorption in children. Cancer. 1982 Feb 15; 49(4):646-50.
  195. Stafford RJ, Grand RJ. Hereditary disease of the exocrine pancreas. Clin Gastroenterol. 1982 Jan; 11(1):141-70.
  196. Spivak W, Grand RJ, Eraklis A. A case of primary sclerosing cholangitis in childhood. Gastroenterology. 1982 Jan; 82(1):129-32.
  197. Montgomery RK, Sybicki MA, Grand RJ. Autonomous biochemical and morphological differentiation in fetal rat intestine transplanted at 17 and 20 days of gestation. Dev Biol. 1981 Oct 15; 87(1):76-84.
  198. Winter HS, Grand RJ. Gastroesophageal reflux. Pediatrics. 1981 Jul; 68(1):134-6.
  199. Wall CM, Grand RJ, Perry SV. Biological activities of the peptides obtained by digestion of troponin C and calmodulin with thrombin. Biochem J. 1981 Apr 1; 195(1):307-16.
  200. Hyams JS, Stafford RJ, Grand RJ, Watkins JB. Correlation of lactose breath hydrogen test, intestinal morphology, and lactase activity in young children. J Pediatr. 1980 Oct; 97(4):609-12.
  201. Grand RJ, Perry SV. The binding of calmodulin to myelin basic protein and histone H2B. Biochem J. 1980 Aug 1; 189(2):227-40.
  202. Kelts DG, Grand RJ. Inflammatory bowel disease in children and adolescents. Curr Probl Pediatr. 1980 Mar; 10(5):1-40.
  203. Grand RJ, Nairn AC, Perry SV. The preparation of calmodulins from barley (Hordeum sp.) and basidiomycete fungi. Biochem J. 1980 Mar 1; 185(3):755-60.
  204. Grand RJ. Malnutrition and inflammatory bowel disease. Curr Concepts Nutr. 1980; 9:125-40.
  205. Hyams JS, Durbin WA, Grand RJ, Goldmann DA. Salmonella bacteremia in the first year of life. J Pediatr. 1980 Jan; 96(1):57-9.
  206. Grand RJ, Perry SV. Calmodulin-binding proteins from brain and other tissues. Biochem J. 1979 Nov 1; 183(2):285-95.
  207. Grand RJ. Perirectal abscess. Am J Dis Child. 1979 Nov; 133(11):1203-4.
  208. Ulshen MH, Grand RJ. Site of substrate stimulation of jejunal sucrase in the rat. J Clin Invest. 1979 Oct; 64(4):1097-1102.
  209. Grand RJ. Wilson's disease. Mayo Clin Proc. 1979 Apr; 54(4):277-8.
  210. Kelts DG, Grand RJ, Shen G, Watkins JB, Werlin SL, Boehme C. Nutritional basis of growth failure in children and adolescents with Crohn's disease. Gastroenterology. 1979 Apr; 76(4):720-7.
  211. Werlin SL, Grand RJ. Development of secretory mechanisms in rat pancreas. Am J Physiol. 1979 Apr; 236(4):E446-50.
  212. Perman JA, Werlin SL, Grand RJ, Watkins JB. Laboratory measures of copper metabolism in the differentiation of chronic active hepatitis and Wilson disease in children. J Pediatr. 1979 Apr; 94(4):564-8.
  213. Katz AJ, Grand RJ. All that flattens is not "sprue". Gastroenterology. 1979 Feb; 76(2):375-7.
  214. Grand RJ, Perry SV, Weeks RA. Troponin C-like proteins (calmodulins) from mammalian smooth muscle and other tissues. Biochem J. 1979 Feb 1; 177(2):521-9.
  215. Grand RJ, Sutphen JL, Montgomery RK. The immature intestine: implications for nutrition of the neonate. Ciba Found Symp. 1979 Jan 16-18; (70):293-311.
  216. Werlin SL, Grand RJ, Perman JA, Watkins JB. Diagnostic dilemmas of Wilson's disease: diagnosis and treatment. Pediatrics. 1978 Jul; 62(1):47-51.
  217. Werlin SL, Grand RJ, Drum DE. Congenital hypertrophic pyloric stenosis: the role of gastrin reevaluated. Pediatrics. 1978 Jun; 61(6):883-5.
  218. Lawson EE, Grand RJ, Neff RK, Cohen LF. Clinical estimation of liver span in infants and children. Am J Dis Child. 1978 May; 132(5):474-6.
  219. Kaufman ME, Grand RJ. Secretory capacity of isolated pancreatic acinar cells. Pediatr Res. 1978 Apr; 12(4 Pt 1):288-92.
  220. Werlin SL, Grand RJ. Bloody diarrhea--a new complication of sulfasalazine. J Pediatr. 1978 Mar; 92(3):450-1.
  221. Grand RJ, Schay MI. Development of secretory function in rat parotid gland. Pediatr Res. 1978 Feb; 12(2):100-4.
  222. Wilkinson JM, Grand RJ. Comparison of amino acid sequence of troponin I from different striated muscles. Nature. 1978 Jan 5; 271(5640):31-5.
  223. Perman JA, Grand RJ. Acute and chronic hepatitis in children. Postgrad Med. 1978 Jan; 63(1):191-3, 196-200.
  224. Katz AJ, Goldman H, Grand RJ. Gastric mucosal biopsy in eosinophilic (allergic) gastroenteritis. Gastroenterology. 1977 Oct; 73(4 Pt 1):705-9.
  225. Grand RJ, Wilkinson JM. The amino acid sequence of rabbit slow-muscle troponin I. Biochem J. 1977 Oct 1; 167(1):183-92.
  226. Werlin SL, Grand RJ. Severe colitis in children and adolescents: diagnosis. Course, and treatment. Gastroenterology. 1977 Oct; 73(4 Pt 1):828-32.
  227. Grand RJ. Too many abbreviations. Gastroenterology. 1977 Jun; 72(6):1367.
  228. Perman JA, Werlin SL, Watkins JB, Grand RJ. Wilson's disease and chronic active hepatitis. Lancet. 1977 May 7; 1(8019):1008.
  229. Neutra MR, Grand RJ, Trier JS. Glycoprotein synthesis, transport, and secretion by epithelial cells of human rectal mucosa: normal and cystic fibrosis. Lab Invest. 1977 May; 36(5):535-46.
  230. Homer DR, Grand RJ, Colodny AH. Growth, course, and prognosis after surgery for Crohn's disease in children and adolescents. Pediatrics. 1977 May; 59(5):717-25.
  231. Jacobson MS, Kevy SV, Grand RJ. Effects of a plasticizer leached from polyvinyl chloride on the subhuman primate: a consequence of chronic transfusion therapy. J Lab Clin Med. 1977 May; 89(5):1066-79.
  232. Javitt NB, Keating JP, Grand RJ, Harris RC. Serum bile acid patterns in neonatal hepatitis and extrahepatic biliary atresia. J Pediatr. 1977 May; 90(5):736-9.
  233. Watkins JB, Katz AJ, Grand RJ. Neonatal hepatitis: a diagnostic approach. Adv Pediatr. 1977; 24:399-454.
  234. Grand RJ, Wilkinson JM. The amino acid sequence of rabbit cardiac troponin I. Biochem J. 1976 Dec 1; 159(3):633-41.
  235. Khettery J, Effmann E, Grand RJ, Treves S. Effect of pentagastrin, histalog, glucagon, secretin, and perchlorate on the gastric handling of 99mTc pertechnetate in mice. Radiology. 1976 Sep; 120(3):629-31.
  236. Grand RJ, Watkins JB, Torti FM. Development of the human gastrointestinal tract. A review. Gastroenterology. 1976 May; 70(5 PT.1):790-810.
  237. Syska H, Wilkinson JM, Grand RJ, Perry SV. The relationship between biological activity and primary structure of troponin I from white skeletal muscle of the rabbit. Biochem J. 1976 Feb 1; 153(2):375-87.
  238. Bhan AK, Grand RJ, Colten HR, Alper CA. Liver in alpha1-antitrypsin deficiency: morphologic observations and in vitro synthesis of alpha1-antitrypsin. Pediatr Res. 1976 Jan; 10(1):35-40.
  239. Grand RJ, Vawter GF. Juvenile Wilson disease: histologic and functional studies during penicillamine therapy. J Pediatr. 1975 Dec; 87(6 Pt 2):1161-70.
  240. Grand RJ, Homer DR. Approaches to inflammatory bowel disease in childhood and adolescence. Pediatr Clin North Am. 1975 Nov; 22(4):835-50.
  241. Grand RJ, Ulshen MH. Clinical and physiological abnormalities in hepatic function. Pediatr Clin North Am. 1975 Nov; 22(4):897-928.
  242. Wilkinson JM, Grand RJ. The amino acid sequence of troponin I from rabbit skeletal muscle. Biochem J. 1975 Aug; 149(2):493-6.
  243. Grand RJ, Watkins JB, Katz AJ, Lawson EE. Letter: Neonatal jaundice: recent developments. N Engl J Med. 1975 May 8; 292(19):1028.
  244. Grand RJ, Chong DA, Ryan SJ. Postnatal development of adenylate cyclase in rat salivary glands: patterns of hormonal sensitivity. Am J Physiol. 1975 Feb; 228(2):608-12.
  245. Grand RJ, Schay MI, Jaksina S. Development and control of intestinal and hepatic fructokinase. Pediatr Res. 1974 Aug; 8(8):765-70.
  246. Antonowicz I, Chang SK, Grand RJ. Development and distribution of lysosomal enzymes and disaccharidases in human fetal intestine. Gastroenterology. 1974 Jul; 67(1):51-8.
  247. Leapman SB, Deutsch AA, Grand RJ, Folkman J. Transplantation of fetal intestine: survival and function in a subcutaneous location in adult animals. Ann Surg. 1974 Jan; 179(1):109-14.
  248. Grand RJ, Torti FM, Jaksina S. Development of intestinal adenyl cyclase and its response to cholera enterotoxin. J Clin Invest. 1973 Aug; 52(8):2053-9.
  249. Grand RJ, Jaksina S. Additional studies on the regulation of carbohydrate-dependent enzymes in the jejunum: changes in amino acid pools, protein synthesis, and the effect of actinomycin-D. Gastroenterology. 1973 Mar; 64(3):429-37.
  250. Lloyd-Still JD, Grand RJ, Khaw KT, Shwachman H. The use of corticosteroids in celiac crisis. J Pediatr. 1972 Dec; 81(6):1074-81.
  251. Grand RJ, Colodny AH. Increased requirement for magnesium during parenteral therapy for granulomatous colitis. J Pediatr. 1972 Oct; 81(4):788-90.
  252. Grand RJ, Lloyd-Still JD, Khaw KT, Shwachman H. Disaccharidase activity in small-bowel biopsies. N Engl J Med. 1972 Feb 17; 286(7):379.
  253. Grand RJ. Changing patterns of gastrointestinal manifestations of cystic fibrosis. Survey of recent progress in diagnosis and treatment. Clin Pediatr (Phila). 1970 Oct; 9(10):588-93.
  254. Holsclaw DS, Grand RJ, Shwachman H. Massive hemoptysis in cystic fibrosis. J Pediatr. 1970 Jun; 76(6):829-38.
  255. Grand RJ, Gross PR. Translation-level control of amylase and protein synthesis by epinephrine. Proc Natl Acad Sci U S A. 1970 Apr; 65(4):1081-8.
  256. Grand RJ, Gross PR. Independent smulation of secretion and protein snthesis in rat parotid gland. The influence of epinephrine and dibutyryl cyclic adenosine 3',5'-monophosphate. J Biol Chem. 1969 Oct 25; 244(20):5608-15.
  257. Grand RJ, Di Sant'Agnese PA, Talamo RC, Pallavicini JC. The effects of exogenous aldosterone on sweat electrolytes. I. Normal subjects. J Pediatr. 1967 Mar; 70(3):346-56.
  258. Grand RJ, Di Sant'Agnese PA, Talamo RC, Pallavicini JC. The effects of exogenous aldosterone on sweat electrolytes. II. Patients with cystic fibrosis of the pancreas. J Pediatr. 1967 Mar; 70(3):357-68.
  259. Grand RJ, Schwartz RH, di Sant'Agnese PA, Gelderman AH. Macroscopic cysts of the pancreas in a case of cystic fibrosis. J Pediatr. 1966 Sep; 69(3):393-8.
  260. Grand RJ, Rosen SW, Di Sant'Agnese PA, Kirkham WR. Unusual case of XXY Klinefelter's syndrome with pancreatic insufficiency, hypothyroidism, deafness, chronic lung disease, dwarfism and microcephaly. Am J Med. 1966 Sep; 41(3):478-85.
  261. Grand RJ, Talamo RC, Di Sant' Agnese PA, Schwartz RH. Pregnancy in cystic fibrosis of the pancreas. JAMA. 1966 Mar 21; 195(12):993-1000.
  262. Baffour-Awuah NY, Delemarre E, Fujiwara Y, Heijmans J, Boerwinkel D, Algra S, Fialkovich JJ, Islam S, Bosse T, Grand RJ, Krasinski SD, Montgomery RK. Characterization of expression in mice of a transgene containing 3.3 kb of the human lactase-phlorizin hydrolase (LPH) 5' flanking sequence. Dig Dis Sci. 2011 Jan; 56(1):59-69.
  263. Ulshen MH, Grand RJ, Crain JD, Gelfand EW. Hepatoxicity with encephalopathy associated with aspirin therapy in rheumatoid arthritis. J Pediatr. 1978 Dec; 93(6):1034-7.
  264. Hyams JS, Ferry GD, Mandel FS, Gryboski JD, Kibort PM, Kirschner BS, Griffiths AM, Katz AJ, Grand RJ, Boyle JT, et al. Development and validation of a pediatric Crohn's disease activity index. J Pediatr Gastroenterol Nutr. 1991 May; 12(4):439-47.
  265. Rosenfield N, Grand RJ, Watkins JB, Ballantine TV, Levey RH. Cholelithiasis and Wilson disease. J Pediatr. 1978 Feb; 92(2):210-3.
  266. Hammond EM, Brunet CL, Johnson GD, Parkhill J, Milner AE, Brady G, Gregory CD, Grand RJ. Homology between a human apoptosis specific protein and the product of APG5, a gene involved in autophagy in yeast. FEBS Lett. 1998 Apr 3; 425(3):391-5.
  267. Wojcik JD, Grand RJ, Kimberg DV. Amylase secretion by rabbit parotid gland. Role of cyclic AMP and cyclic GMP. Biochim Biophys Acta. 1975 Dec 5; 411(2):250-62.
  268. Fellows KE, Grand RJ, Colodny AH, Orsini EN, Crocker AC. Combined portal and vena caval hypertension in Gaucher disease: The value of preoperative venography. J Pediatr. 1975 Nov; 87(5):739-43.
  269. Grabham PW, Gallimore PH, Grand RJ. Vitronectin is the major serum protein essential for NGF-mediated neurite outgrowth from PC12 cells. Exp Cell Res. 1992 Oct; 202(2):337-44.
  270. Balistreri WF, Grand R, Hoofnagle JH, Suchy FJ, Ryckman FC, Perlmutter DH, Sokol RJ. Biliary atresia: current concepts and research directions. Summary of a symposium. Hepatology. 1996 Jun; 23(6):1682-92.
  271. Pappa HM, Langereis EJ, Grand RJ, Gordon CM. Prevalence and risk factors for hypovitaminosis D in young patients with inflammatory bowel disease. J Pediatr Gastroenterol Nutr. 2011 Oct; 53(4):361-4.
  272. Imielinski M, Baldassano RN, Griffiths A, Russell RK, Annese V, Dubinsky M, Kugathasan S, Bradfield JP, Walters TD, Sleiman P, Kim CE, Muise A, Wang K, Glessner JT, Saeed S, Zhang H, Frackelton EC, Hou C, Flory JH, Otieno G, Chiavacci RM, Grundmeier R, Castro M, Latiano A, Dallapiccola B, Stempak J, Abrams DJ, Taylor K, McGovern D, Silber G, Wrobel I, Quiros A, Barrett JC, Hansoul S, Nicolae DL, Cho JH, Duerr RH, Rioux JD, Brant SR, Silverberg MS, Taylor KD, Barmuda MM, Bitton A, Dassopoulos T, Datta LW, Green T, Griffiths AM, Kistner EO, Murtha MT, Regueiro MD, Rotter JI, Schumm LP, Steinhart AH, Targan SR, Xavier RJ, Libioulle C, Sandor C, Lathrop M, Belaiche J, Dewit O, Gut I, Heath S, Laukens D, Mni M, Rutgeerts P, Van Gossum A, Zelenika D, Franchimont D, Hugot JP, de Vos M, Vermeire S, Louis E, Cardon LR, Anderson CA, Drummond H, Nimmo E, Ahmad T, Prescott NJ, Onnie CM, Fisher SA, Marchini J, Ghori J, Bumpstead S, Gwillam R, Tremelling M, Delukas P, Mansfield J, Jewell D, Satsangi J, Mathew CG, Parkes M, Georges M, Daly MJ, Heyman MB, Ferry GD, Kirschner B, Lee J, Essers J, Grand R, Stephens M, Levine A, Piccoli D, Van Limbergen J, Cucchiara S, Monos DS, Guthery SL, Denson L, Wilson DC, Grant SF, Daly M, Silverberg MS, Satsangi J, Hakonarson H. Common variants at five new loci associated with early-onset inflammatory bowel disease. Nat Genet. 2009 Dec; 41(12):1335-40.
  273. Montgomery RK, Sybicki MA, Forcier AG, Grand RJ. Rat intestinal microvillus membrane sucrase-isomaltase is a single high molecular weight protein and fully active enzyme in the absence of luminal factors. Biochim Biophys Acta. 1981 Oct 13; 661(2):346-9.
  274. Griscom NT, Kirkpatrick JA, Girdany BR, Berdon WE, Grand RJ, Mackie GG. Gastric antral narrowing in chronic granulomatous disease of childhood. Pediatrics. 1974 Oct; 54(4):456-60.
  275. Grand RJ. Amino acid pools in rat parotid gland during epinephrine-stimulated protein synthesis. Biochim Biophys Acta. 1969 Nov 19; 195(1):252-4.
  276. Blackburn GL, Grand RJ, Licht DJ, Richardson BE, Soteriades ES, Willcutts HD. More on the obesity problem. N Engl J Med. 1998 Jun 4; 338(23):1702.
  277. Grand RJ, Point W. Evaluation of gastrointestinal bleeding during adolescence. Postgrad Med. 1974 Jul; 56(1):87-93.
  278. Lloyd-Still JD, Grand RJ, Vawter GF. Tetracycline hepatotoxicity in the differential diagnosis of postoperative jaundice. J Pediatr. 1974 Mar; 84(3):366-70.
  279. van Wering HM, Moyer L, Grand RJ, Krasinski SD. Novel interaction at the Cdx-2 binding sites of the lactase-phlorizin hydrolase promoter. Biochem Biophys Res Commun. 2002 Dec 13; 299(4):587-93.
  280. Essers JB, Lee JJ, Kugathasan S, Stevens CR, Grand RJ, Daly MJ. Established genetic risk factors do not distinguish early and later onset Crohn's disease. Inflamm Bowel Dis. 2009 Oct; 15(10):1508-14.
  281. Treves S, Grand RJ, Eraklis AJ. Pentagastrin stimulation of technetium-99m uptake by ectopic gastric muscosa in a Meckel's diverticulum. Radiology. 1978 Sep; 128(3):711-2.
  282. Ibrahim AP, Gallimore PH, Grand RJ. The expression of MDM2 and other p53-regulated proteins in the tissues of the developing rat. Biochim Biophys Acta. 1997 Feb 28; 1350(3):306-16.
  283. Beuling E, Bosse T, aan de Kerk DJ, Piaseckyj CM, Fujiwara Y, Katz SG, Orkin SH, Grand RJ, Krasinski SD. GATA4 mediates gene repression in the mature mouse small intestine through interactions with friend of GATA (FOG) cofactors. Dev Biol. 2008 Oct 1; 322(1):179-89.
  284. Cole HA, Grand RJ, Perry SV. Non-correlation of phosphorylation of the P-light chain and the actin activation of the ATPase of chicken gizzard myosin. Biochem J. 1982 Aug 15; 206(2):319-28.
  285. Schmeiser K, Armstrong S, Hammond EM, Grand RJ. Assignment of the yeast APG5 human homologue APG5L to chromosome band 6q21 by fluorescence in situ hybridisation. Cytogenet Cell Genet. 1999; 87(3-4):213-4.
  286. Semrin G, Fishman DS, Bousvaros A, Zholudev A, Saunders AC, Correia CE, Nemeth E, Grand RJ, Weinstein DA. Impaired intestinal iron absorption in Crohn's disease correlates with disease activity and markers of inflammation. Inflamm Bowel Dis. 2006 Dec; 12(12):1101-6.
  287. Park RW, Grand RJ. Gastrointestinal manifestations of cystic fibrosis: a review. Gastroenterology. 1981 Dec; 81(6):1143-61.
  288. Pappa HM, Saslowsky TM, Filip-Dhima R, DiFabio D, Hassani Lahsinoui H, Akkad A, Grand RJ, Gordon CM. Efficacy and harms of nasal calcitonin in improving bone density in young patients with inflammatory bowel disease: a randomized, placebo-controlled, double-blind trial. Am J Gastroenterol. 2011 Aug; 106(8):1527-43.
  289. Molloy DP, Barral PM, Bremner KH, Gallimore PH, Grand RJ. Structural determinants outside the PXDLS sequence affect the interaction of adenovirus E1A, C-terminal interacting protein and Drosophila repressors with C-terminal binding protein. Biochim Biophys Acta. 2001 Mar 9; 1546(1):55-70.
  290. Boudreau F, Rings EH, van Wering HM, Kim RK, Swain GP, Krasinski SD, Moffett J, Grand RJ, Suh ER, Traber PG. Hepatocyte nuclear factor-1 alpha, GATA-4, and caudal related homeodomain protein Cdx2 interact functionally to modulate intestinal gene transcription. Implication for the developmental regulation of the sucrase-isomaltase gene. J Biol Chem. 2002 Aug 30; 277(35):31909-17.
  291. HALL R, GRAND RJ. Effect of radiation on the incorporation of C14-formate into RNA purines in calf thyroid slices in vitro. Endocrinology. 1962 Dec; 71:914-19.
  292. Grand RJ, Lecane PS, Owen D, Grant ML, Roberts S, Levine AJ, Gallimore PH. The high levels of p53 present in adenovirus early region 1-transformed human cells do not cause up-regulation of MDM2 expression. Virology. 1995 Jul 10; 210(2):323-34.
  293. Pappa HM, Gordon CM, Saslowsky TM, Zholudev A, Horr B, Shih MC, Grand RJ. Vitamin D status in children and young adults with inflammatory bowel disease. Pediatrics. 2006 Nov; 118(5):1950-61.
  294. Grand RJ, Perry SV. Preparation of the alkali and P light chains of chicken gizzard myosin. Amino acid sequence of the alkali light chain. Biochem J. 1983 Apr 1; 211(1):267-72.
  295. Li W, Krasinski SD, Verhave M, Montgomery RK, Grand RJ. Three distinct messenger RNA distribution patterns in human jejunal enterocytes. Gastroenterology. 1998 Jul; 115(1):86-92.
  296. Grand RJ, Chong DA, Isselbacher KJ. Intracellular processing of disaccharidases: the effect of actinomycin D. Biochim Biophys Acta. 1971 Feb 28; 261(2):341-52.
  297. Szigethy E, Craig AE, Iobst EA, Grand RJ, Keljo D, DeMaso D, Noll R. Profile of depression in adolescents with inflammatory bowel disease: implications for treatment. Inflamm Bowel Dis. 2009 Jan; 15(1):69-74.
  298. Krasinski SD, Van Wering HM, Tannemaat MR, Grand RJ. Differential activation of intestinal gene promoters: functional interactions between GATA-5 and HNF-1 alpha. Am J Physiol Gastrointest Liver Physiol. 2001 Jul; 281(1):G69-84.
  299. Integlia MJ, Krishnamurthy S, Berhane R, Grand RJ, Dayal Y. Pancreatic metaplasia of the gastric mucosa in pediatric patients. Am J Gastroenterol. 1997 Sep; 92(9):1553-6.
  300. Sedgwick GG, Townsend K, Martin A, Shimwell NJ, Grand RJ, Stewart GS, Nilsson J, Turnell AS. Transcriptional intermediary factor 1? binds to the anaphase-promoting complex/cyclosome and promotes mitosis. Oncogene. 2013 Sep 26; 32(39):4622-33.
  301. Grover AS, Kadiyala V, Banks PA, Grand RJ, Conwell DL, Lightdale JR. The Utility of the Systemic Inflammatory Respsonse Syndrome Score on Admission in Children with Acute Pancreatitis. Pancreas. 2016 Nov 10.
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