Margossian Renee MD

Renee Margossian, MD

Attending, Department of Cardiology

Assistant Professor of Pediatrics, Harvard Medical School

  • Contact: 617-355-6429

Medical Services

Specialties

  • Echocardiography
  • Cardiology

Departments

  • Cardiology
  • Cardiovascular Program

Programs

  • Echocardiography
  • Non-Invasive Cardiac Imaging
  • Cardiomyopathy Program
  • Cardio Oncology Program
To schedule an appointment: Call 617-355-6429 or Request an Appointment
Margossian Renee MD

I strive for a patient and family centered approach to cardiac care, through close collaboration with colleagues in other specialties, such as oncology, other divisions within cardiology and within the cardiomyopathy and non-invasive imaging groups. 

Long-term management of cardiomyopathies requires a team of care providers.  Supporting all members of the team is a core philosophy, through continuous education and investment in regular interpersonal conferences. 

Experience and Education

Education

Graduate Degree

University of Texas at Austin, 1987

Austin, TX

Medical School

University of Texas Southwestern Medical School, 1992

Dallas, TX

Internship

University of Texas Southwestern Medical School/ Children's Medical Center, 1993

Dallas, TX

Residency

University of Texas Southwestern Medical School/ Children's Medical Center, 1995

Dallas, TX

Fellowship

Columbia Presbyterian Medical Center/Babies' and Children's Hospital, 2000

New York, NY

Fellowship

Boston Children's Hospital, 2001

Boston, MA

Certifications

  • Pediatrics, Pediatric Cardiology

Publications

Publications powered by Harvard Catalyst Profiles
  1. Friedberg MK, Margossian R, Lu M, Mercer-Rosa L, Henderson HT, Nutting A, Friedman K, Molina KM, Altmann K, Canter C, Sleeper LA, Colan SD. Systolic-diastolic functional coupling in healthy children and in those with dilated cardiomyopathy. J Appl Physiol (1985). 2016 Jun 1; 120(11):1301-18.
  2. Uzark K, Zak V, Shrader P, McCrindle BW, Radojewski E, Varni JW, Daniels K, Handisides J, Hill KD, Lambert LM, Margossian R, Pemberton VL, Lai WW, Atz AM. Assessment of Quality of Life in Young Patients with Single Ventricle after the Fontan Operation. J Pediatr. 2016 Mar; 170:166-72.e1.
  3. Margossian R, Chen S, Sleeper LA, Tani LY, Shirali G, Golding F, Selamet Tierney ES, Altmann K, Campbell MJ, Szwast A, Sharkey A, Radojewski E, Colan SD. The reproducibility and absolute values of echocardiographic measurements of left ventricular size and function in children are algorithm dependent. J Am Soc Echocardiogr. 2015 May; 28(5):549-558.e1.
  4. Atz AM, Zak V, Mahony L, Uzark K, Shrader P, Gallagher D, Paridon SM, Williams RV, Breitbart RE, Colan SD, Kaltman JR, Margossian R, Pasquali SK, Allen K, Lai WW, Korsin R, Marino BS, Mirarchi N, McCrindle BW. Survival data and predictors of functional outcome an average of 15?years after the Fontan procedure: the pediatric heart network Fontan cohort. Congenit Heart Dis. 2015 Jan-Feb; 10(1):E30-42.
  5. Everitt MD, Sleeper LA, Lu M, Canter CE, Pahl E, Wilkinson JD, Addonizio LJ, Towbin JA, Rossano J, Singh RK, Lamour J, Webber SA, Colan SD, Margossian R, Kantor PF, Jefferies JL, Lipshultz SE. Recovery of echocardiographic function in children with idiopathic dilated cardiomyopathy: results from the pediatric cardiomyopathy registry. J Am Coll Cardiol. 2014 Apr 15; 63(14):1405-13.
  6. Butts RJ, Zak V, Hsu D, Cnota J, Colan SD, Hehir D, Kantor P, Levine JC, Margossian R, Richmond M, Szwast A, Williams D, Williams R, Atz AM. Factors associated with serum B-type natriuretic peptide in infants with single ventricles. Pediatr Cardiol. 2014 Jun; 35(5):879-87.
  7. Lee CK, Margossian R, Sleeper LA, Canter CE, Chen S, Tani LY, Shirali G, Szwast A, Tierney ES, Campbell MJ, Golding F, Wang Y, Altmann K, Colan SD. Variability of M-mode versus two-dimensional echocardiography measurements in children with dilated cardiomyopathy. Pediatr Cardiol. 2014 Apr; 35(4):658-67.
  8. Molina KM, Shrader P, Colan SD, Mital S, Margossian R, Sleeper LA, Shirali G, Barker P, Canter CE, Altmann K, Radojewski E, Tierney ES, Rychik J, Tani LY. Predictors of disease progression in pediatric dilated cardiomyopathy. Circ Heart Fail. 2013 Nov; 6(6):1214-22.
  9. McCrindle BW, Zak V, Pemberton VL, Lambert LM, Vetter VL, Lai WW, Uzark K, Margossian R, Atz AM, Cook A, Newburger JW. Functional health status in children and adolescents after Fontan: comparison of generic and disease-specific assessments. Cardiol Young. 2014 Jun; 24(3):469-77.
  10. Williams RV, Margossian R, Lu M, Atz AM, Bradley TJ, Jay Campbell M, Colan SD, Gallagher D, Lai WW, Pearson GD, Prakash A, Shirali G, Cohen MS. Factors impacting echocardiographic imaging after the Fontan procedure: a report from the pediatric heart network fontan cross-sectional study. Echocardiography. 2013 Oct; 30(9):1098-106.
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  12. Leonardi B, Margossian R, Sanders SP, Chinali M, Colan SD. Ventricular mechanics in patients with aortic valve disease: longitudinal, radial, and circumferential components. Cardiol Young. 2014 Feb; 24(1):105-12.
  13. Cnota JF, Allen KR, Colan S, Covitz W, Graham EM, Hehir DA, Levine JC, Margossian R, McCrindle BW, Minich LL, Natarajan S, Richmond ME, Hsu DT. Superior cavopulmonary anastomosis timing and outcomes in infants with single ventricle. J Thorac Cardiovasc Surg. 2013 May; 145(5):1288-96.
  14. Webber SA, Lipshultz SE, Sleeper LA, Lu M, Wilkinson JD, Addonizio LJ, Canter CE, Colan SD, Everitt MD, Jefferies JL, Kantor PF, Lamour JM, Margossian R, Pahl E, Rusconi PG, Towbin JA. Outcomes of restrictive cardiomyopathy in childhood and the influence of phenotype: a report from the Pediatric Cardiomyopathy Registry. Circulation. 2012 Sep 4; 126(10):1237-44.
  15. Atz AM, Travison TG, McCrindle BW, Mahony L, Glatz AC, Kaza AK, Breitbart RE, Colan SD, Kaltman JR, Margossian R, Pasquali SK, Wang Y, Gersony WM. Cardiac performance and quality of life in patients who have undergone the Fontan procedure with and without prior superior cavopulmonary connection. Cardiol Young. 2013 Jun; 23(3):335-43.
  16. Williams RV, Travison T, Kaltman JR, Cecchin F, Colan SD, Idriss SF, Lu M, Margossian R, Reed JH, Silver ES, Stephenson EA, Vetter VL. Comparison of Fontan survivors with and without pacemakers: a report from the Pediatric Heart Network Fontan Cross-Sectional Study. Congenit Heart Dis. 2013 Jan-Feb; 8(1):32-9.
  17. Colan SD, Shirali G, Margossian R, Gallagher D, Altmann K, Canter C, Chen S, Golding F, Radojewski E, Camitta M, Carboni M, Rychik J, Stylianou M, Tani LY, Selamet Tierney ES, Wang Y, Sleeper LA. The ventricular volume variability study of the Pediatric Heart Network: study design and impact of beat averaging and variable type on the reproducibility of echocardiographic measurements in children with chronic dilated cardiomyopathy. J Am Soc Echocardiogr. 2012 Aug; 25(8):842-854.e6.
  18. Rhodes J, Margossian R, Sleeper LA, Barker P, Bradley TJ, Lu M, Fogel M, Harris MA, Lai WW, Powell AJ, Puchalski MD, Shirali G, Colan SD. Non-geometric echocardiographic indices of ventricular function in patients with a Fontan circulation. J Am Soc Echocardiogr. 2011 Nov; 24(11):1213-9.
  19. Saleeb SF, Margossian R, Spencer CT, Alexander ME, Smoot LB, Dorfman AL, Bergersen L, Gauvreau K, Marx GR, Colan SD. Reproducibility of echocardiographic diagnosis of left ventricular noncompaction. J Am Soc Echocardiogr. 2012 Feb; 25(2):194-202.
  20. Kaza AK, Colan SD, Jaggers J, Lu M, Atz AM, Sleeper LA, McCrindle BW, Lambert LM, Margossian R, Lacro RV, Richmond ME, Natarajan S, Minich LL. Surgical interventions for atrioventricular septal defect subtypes: the pediatric heart network experience. Ann Thorac Surg. 2011 Oct; 92(4):1468-75; discussion 1475.
  21. Spencer CT, Byrne BJ, Bryant RM, Margossian R, Maisenbacher M, Breitenger P, Benni PB, Redfearn S, Marcus E, Cade WT. Impaired cardiac reserve and severely diminished skeletal muscle O2 utilization mediate exercise intolerance in Barth syndrome. Am J Physiol Heart Circ Physiol. 2011 Nov; 301(5):H2122-9.
  22. Williams RV, Zak V, Ravishankar C, Altmann K, Anderson J, Atz AM, Dunbar-Masterson C, Ghanayem N, Lambert L, Lurito K, Medoff-Cooper B, Margossian R, Pemberton VL, Russell J, Stylianou M, Hsu D. Factors affecting growth in infants with single ventricle physiology: a report from the Pediatric Heart Network Infant Single Ventricle Trial. J Pediatr. 2011 Dec; 159(6):1017-22.e2.
  23. Banka P, Sleeper LA, Atz AM, Cowley CG, Gallagher D, Gillespie MJ, Graham EM, Margossian R, McCrindle BW, Sang CJ, Williams IA, Newburger JW. Practice variability and outcomes of coil embolization of aortopulmonary collaterals before Fontan completion: a report from the Pediatric Heart Network Fontan Cross-Sectional Study. Am Heart J. 2011 Jul; 162(1):125-30.
  24. Atz AM, Travison TG, McCrindle BW, Mahony L, Quartermain M, Williams RV, Breitbart RE, Lu M, Radojewski E, Margossian R, Covitz W, Gersony WM. Late status of Fontan patients with persistent surgical fenestration. J Am Coll Cardiol. 2011 Jun 14; 57(24):2437-43.
  25. Friedman KG, Margossian R, Graham DA, Harrild DM, Emani SM, Wilkins-Haug LE, McElhinney DB, Tworetzky W. Postnatal left ventricular diastolic function after fetal aortic valvuloplasty. Am J Cardiol. 2011 Aug 15; 108(4):556-60.
  26. Mital S, Chung WK, Colan SD, Sleeper LA, Manlhiot C, Arrington CB, Cnota JF, Graham EM, Mitchell ME, Goldmuntz E, Li JS, Levine JC, Lee TM, Margossian R, Hsu DT. Renin-angiotensin-aldosterone genotype influences ventricular remodeling in infants with single ventricle. Circulation. 2011 May 31; 123(21):2353-62.
  27. Guinan EC, Hewett EK, Domaney NM, Margossian R. Outcome of hematopoietic stem cell transplant in children with congenital heart disease. Pediatr Transplant. 2011 Feb; 15(1):75-80.
  28. Daly KP, Colan SD, Blume ED, Margossian R, Gauvreau K, Duncan C, Lehmann LE, Chen MH. Changes in echocardiographic measures of systolic and diastolic function in children 1 year after hematopoietic SCT. Bone Marrow Transplant. 2011 Dec; 46(12):1532-9.
  29. Printz BF, Sleeper LA, Newburger JW, Minich LL, Bradley T, Cohen MS, Frank D, Li JS, Margossian R, Shirali G, Takahashi M, Colan SD. Noncoronary cardiac abnormalities are associated with coronary artery dilation and with laboratory inflammatory markers in acute Kawasaki disease. J Am Coll Cardiol. 2011 Jan 4; 57(1):86-92.
  30. Margossian R, Lu M, Minich LL, Bradley TJ, Cohen MS, Li JS, Printz BF, Shirali GS, Sleeper LA, Newburger JW, Colan SD. Predictors of coronary artery visualization in Kawasaki disease. J Am Soc Echocardiogr. 2011 Jan; 24(1):53-9.
  31. Atz AM, Hawkins JA, Lu M, Cohen MS, Colan SD, Jaggers J, Lacro RV, McCrindle BW, Margossian R, Mosca RS, Sleeper LA, Minich LL. Surgical management of complete atrioventricular septal defect: associations with surgical technique, age, and trisomy 21. J Thorac Cardiovasc Surg. 2011 Jun; 141(6):1371-9.
  32. Cohen MS, Zak V, Atz AM, Printz BF, Pinto N, Lambert L, Pemberton V, Li JS, Margossian R, Dunbar-Masterson C, McCrindle BW. Anthropometric measures after Fontan procedure: implications for suboptimal functional outcome. Am Heart J. 2010 Dec; 160(6):1092-8, 1098.e1.
  33. Anderson PA, Breitbart RE, McCrindle BW, Sleeper LA, Atz AM, Hsu DT, Lu M, Margossian R, Williams RV. The Fontan patient: inconsistencies in medication therapy across seven pediatric heart network centers. Pediatr Cardiol. 2010 Nov; 31(8):1219-28.
  34. Foerster SR, Canter CE, Cinar A, Sleeper LA, Webber SA, Pahl E, Kantor PF, Alvarez JA, Colan SD, Jefferies JL, Lamour JM, Margossian R, Messere JE, Rusconi PG, Shaddy RE, Towbin JA, Wilkinson JD, Lipshultz SE. Ventricular remodeling and survival are more favorable for myocarditis than for idiopathic dilated cardiomyopathy in childhood: an outcomes study from the Pediatric Cardiomyopathy Registry. Circ Heart Fail. 2010 Nov; 3(6):689-97.
  35. Stephenson EA, Lu M, Berul CI, Etheridge SP, Idriss SF, Margossian R, Reed JH, Prakash A, Sleeper LA, Vetter VL, Blaufox AD. Arrhythmias in a contemporary fontan cohort: prevalence and clinical associations in a multicenter cross-sectional study. J Am Coll Cardiol. 2010 Sep 7; 56(11):890-6.
  36. Hsu DT, Zak V, Mahony L, Sleeper LA, Atz AM, Levine JC, Barker PC, Ravishankar C, McCrindle BW, Williams RV, Altmann K, Ghanayem NS, Margossian R, Chung WK, Border WL, Pearson GD, Stylianou MP, Mital S. Enalapril in infants with single ventricle: results of a multicenter randomized trial. Circulation. 2010 Jul 27; 122(4):333-40.
  37. Beroukhim RS, Graham DA, Margossian R, Brown DW, Geva T, Colan SD. An echocardiographic model predicting severity of aortic regurgitation in congenital heart disease. Circ Cardiovasc Imaging. 2010 Sep; 3(5):542-9.
  38. Minich LL, Atz AM, Colan SD, Sleeper LA, Mital S, Jaggers J, Margossian R, Prakash A, Li JS, Cohen MS, Lacro RV, Klein GL, Hawkins JA. Partial and transitional atrioventricular septal defect outcomes. Ann Thorac Surg. 2010 Feb; 89(2):530-6.
  39. McCrindle BW, Zak V, Sleeper LA, Paridon SM, Colan SD, Geva T, Mahony L, Li JS, Breitbart RE, Margossian R, Williams RV, Gersony WM, Atz AM. Laboratory measures of exercise capacity and ventricular characteristics and function are weakly associated with functional health status after Fontan procedure. Circulation. 2010 Jan 5; 121(1):34-42.
  40. Williams IA, Sleeper LA, Colan SD, Lu M, Stephenson EA, Newburger JW, Gersony WM, Cohen MS, Cnota JF, Atz AM, Williams RV, Margossian R, Powell AJ, Stylianou MP, Hsu DT. Functional state following the Fontan procedure. Cardiol Young. 2009 Aug; 19(4):320-30.
  41. Margossian R, Schwartz ML, Prakash A, Wruck L, Colan SD, Atz AM, Bradley TJ, Fogel MA, Hurwitz LM, Marcus E, Powell AJ, Printz BF, Puchalski MD, Rychik J, Shirali G, Williams R, Yoo SJ, Geva T. Comparison of echocardiographic and cardiac magnetic resonance imaging measurements of functional single ventricular volumes, mass, and ejection fraction (from the Pediatric Heart Network Fontan Cross-Sectional Study). Am J Cardiol. 2009 Aug 1; 104(3):419-28.
  42. Hsu DT, Mital S, Ravishankar C, Margossian R, Li JS, Sleeper LA, Williams RV, Levine JC, McCrindle BW, Atz AM, Servedio D, Mahony L. Rationale and design of a trial of angiotensin-converting enzyme inhibition in infants with single ventricle. Am Heart J. 2009 Jan; 157(1):37-45.
  43. Leonardi B, Margossian R, Colan SD, Powell AJ. Relationship of magnetic resonance imaging estimation of myocardial iron to left ventricular systolic and diastolic function in thalassemia. JACC Cardiovasc Imaging. 2008 Sep; 1(5):572-8.
  44. Anderson PA, Sleeper LA, Mahony L, Colan SD, Atz AM, Breitbart RE, Gersony WM, Gallagher D, Geva T, Margossian R, McCrindle BW, Paridon S, Schwartz M, Stylianou M, Williams RV, Clark BJ. Contemporary outcomes after the Fontan procedure: a Pediatric Heart Network multicenter study. J Am Coll Cardiol. 2008 Jul 8; 52(2):85-98.
  45. Paridon SM, Mitchell PD, Colan SD, Williams RV, Blaufox A, Li JS, Margossian R, Mital S, Russell J, Rhodes J. A cross-sectional study of exercise performance during the first 2 decades of life after the Fontan operation. J Am Coll Cardiol. 2008 Jul 8; 52(2):99-107.
  46. Margossian R. Contemporary management of pediatric heart failure. Expert Rev Cardiovasc Ther. 2008 Feb; 6(2):187-97.
  47. Webster G, Margossian R, Alexander ME, Cecchin F, Triedman JK, Walsh EP, Berul CI. Impact of transvenous ventricular pacing leads on tricuspid regurgitation in pediatric and congenital heart disease patients. J Interv Card Electrophysiol. 2008 Jan; 21(1):65-8.
  48. Ismee A Williams, Andrew M Atz, James F Cnota, Meryl S Cohen, Steven D Colan, Welton M Gersony, Minmin Lu, Renee E Margossian, Jane W Newburger, Andrew J Powell, Lynn A Sleeper, Elizabeth A Stephenson, Mario Stylianou, Richard V Williams, and Daphne T Hsu . Predictors of Functional Status following Fontan Palliation: Development of a Fontan Functional Score . Circulation. 2007; 116:479.
  49. Susan Foerster, Amy Carey, Lynn Sleeper, Paul Kantor, Jacqueline Lamour, Steven Lipshultz, Renee Margossian, Jane Messere, Elfriede Pahl, Paolo Rusconi, Robert Shaddy, Jeffrey Towbin, Steve Webber, Charles Canter . Comparative Analysis of Outcomes for Pediatric Patients with Biopsy-Proven Myocarditis, Physician-Diagnosed Myocarditis and Idiopathic Dilated Cardiomyopathy. Circulation. 2007; 116:565.
  50. Carolyn T Spencer, Randall M Bryant, Barry Byrne, Elisabeth Heal, Renee Margossian, and W. Todd Cade . Impaired Skeletal Muscle Oxygen Utilization Contributes to Exercise Intolerance in Barth Syndrome . Circulation. 2007; 116:615.
  51. Rhodes J, Margossian R, Darras BT, Colan SD, Jenkins KJ, Geva T, Powell AJ. Safety and efficacy of carvedilol therapy for patients with dilated cardiomyopathy secondary to muscular dystrophy. Pediatr Cardiol. 2008 Mar; 29(2):343-51.
  52. Chen JM, Glickstein JS, Margossian R, Mercando ML, Hellenbrand WE, Mosca RS, Quaegebeur JM. Superior outcomes for repair in infants and neonates with tetralogy of Fallot with absent pulmonary valve syndrome. J Thorac Cardiovasc Surg. 2006 Nov; 132(5):1099-104.
  53. Friehs I, Margossian RE, Moran AM, Cao-Danh H, Moses MA, del Nido PJ. Vascular endothelial growth factor delays onset of failure in pressure-overload hypertrophy through matrix metalloproteinase activation and angiogenesis. Basic Res Cardiol. 2006 May; 101(3):204-13.
  54. Danhaive O, Margossian R, Geva T, Kourembanas S. Pulmonary hypertension and right ventricular dysfunction in growth-restricted, extremely low birth weight neonates. J Perinatol. 2005 Jul; 25(7):495-9.
  55. Tworetzky W, McElhinney DB, Margossian R, Moon-Grady AJ, Sallee D, Goldmuntz E, van der Velde ME, Silverman NH, Allan LD. Association between cardiac tumors and tuberous sclerosis in the fetus and neonate. Am J Cardiol. 2003 Aug 15; 92(4):487-9.
  56. Marcus EN, Munoz RA, Margossian R, Colan SD, Wessel DL. Echocardiographic assessment of the right ventricular response to hypertension in neonates on the basis of average-shaped contraction models. J Am Soc Echocardiogr. 2002 Oct; 15(10 Pt 2):1145-53.
  57. Margossian RE, Solowiejczyk D, Bourlon F, Apfel H, Gersony WM, Hordof AJ, Quaegebeur J. Septation of the single ventricle: revisited. J Thorac Cardiovasc Surg. 2002 Sep; 124(3):442-7.
To schedule an appointment: Call 617-355-6429 or Request an Appointment

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