Paul Tannous MD

Paul Tannous, MD, PhD

Instructor in Cardiology

Instructor in Pediatrics, Harvard Medical School

    Contact: 617-355-8228
  • Fax: 617-730-7548

Medical Services


  • Interventional Cardiology


  • Cardiology


  • English


  • Cardiac Catheterization Labs
To schedule an appointment: Call 617-355-8228

Experience and Education


Medical School

University of Texas Southwestern Medical Center at Dallas, 2009

Dallas, TX

Graduate School - PhD in Integrative Biology

University of Texas Southwestern Medical Center at Dallas, 2009

Dallas, TX

Internship - Pediatrics

University of Texas Southwestern Medical Center at Dallas, 2010

Dallas, TX

Residency - Pediatrics

University of Texas Southwestern Medical Center at Dallas, 2012

Dallas , TX

Fellowship - Pediatric Cardiology

Boston Children's Hospital, 2015

Boston, MA

Senior Fellowship - Interventional Cardiology

Boston Children's Hospital, 2016

Boston, MA

Professional History

Dr. Tannous was born and raised in Iowa City, IA, and completed his undergraduate education at the University of Wisconsin – Madison.  He then joined the Medical Scientist Training Program at the University of Texas Southwestern Medical Center where he completed medical school and earned his PhD studying mechanisms of myocardial remodeling.  Dr. Tannous stayed in Dallas for pediatric residency, and then came to Boston Children’s Hospital for general cardiology fellowship, followed by a senior year in interventional cardiology.  As a member of the Division of Invasive Cardiology, Dr. Tannous specializes in transcatheter care of congenital heart disease.  In addition to his clinical duties, Dr. Tannous is also a La Due Research Fellow, conducting translational research regarding the development of pulmonary vascular malformations in the setting of cyanotic congenital heart disease.  


Publications powered by Harvard Catalyst Profiles
  1. Tannous P, Ghelani SJ, Marshall AC, Porras D. Angiographically detectable Thebesian veins are a dynamic and reversible finding in the setting of congenital heart disease. Congenit Heart Dis. 2017 Mar 10.
  2. Allan CK, Tannous P, DeWitt E, Farias M, Mansfield L, Ronai C, Schidlow D, Sanders SP, Lock JE, Newburger JW, Brown DW. A Pediatric Cardiology Fellowship Boot Camp improves trainee confidence. Cardiol Young. 2016 Dec; 26(8):1514-1521.
  3. Berry JM, Le V, Rotter D, Battiprolu PK, Grinsfelder B, Tannous P, Burchfield JS, Czubryt M, Backs J, Olson EN, Rothermel BA, Hill JA. Reversibility of adverse, calcineurin-dependent cardiac remodeling. Circ Res. 2011 Aug 05; 109(4):407-17.
  4. Tannous P, Zhu H, Johnstone JL, Shelton JM, Rajasekaran NS, Benjamin IJ, Nguyen L, Gerard RD, Levine B, Rothermel BA, Hill JA. Autophagy is an adaptive response in desmin-related cardiomyopathy. Proc Natl Acad Sci U S A. 2008 Jul 15; 105(28):9745-50.
  5. Tannous P, Zhu H, Nemchenko A, Berry JM, Johnstone JL, Shelton JM, Miller FJ, Rothermel BA, Hill JA. Intracellular protein aggregation is a proximal trigger of cardiomyocyte autophagy. Circulation. 2008 Jun 17; 117(24):3070-8.
  6. Krishnan V, Han MH, Graham DL, Berton O, Renthal W, Russo SJ, Laplant Q, Graham A, Lutter M, Lagace DC, Ghose S, Reister R, Tannous P, Green TA, Neve RL, Chakravarty S, Kumar A, Eisch AJ, Self DW, Lee FS, Tamminga CA, Cooper DC, Gershenfeld HK, Nestler EJ. Molecular adaptations underlying susceptibility and resistance to social defeat in brain reward regions. Cell. 2007 Oct 19; 131(2):391-404.
  7. Zhu H, Tannous P, Johnstone JL, Kong Y, Shelton JM, Richardson JA, Le V, Levine B, Rothermel BA, Hill JA. Cardiac autophagy is a maladaptive response to hemodynamic stress. J Clin Invest. 2007 Jul; 117(7):1782-93.
  8. Kong Y, Tannous P, Lu G, Berenji K, Rothermel BA, Olson EN, Hill JA. Suppression of class I and II histone deacetylases blunts pressure-overload cardiac hypertrophy. Circulation. 2006 Jun 06; 113(22):2579-88.
  9. Richardson KE, Tannous P, Berenji K, Nolan B, Bayless KJ, Davis GE, Rothermel BA, Hill JA. Guanosine triphosphatase activation occurs downstream of calcineurin in cardiac hypertrophy*. J Investig Med. 2005 Dec; 53(8):414-24.
  10. Rothermel BA, Berenji K, Tannous P, Kutschke W, Dey A, Nolan B, Yoo KD, Demetroulis E, Gimbel M, Cabuay B, Karimi M, Hill JA. Differential activation of stress-response signaling in load-induced cardiac hypertrophy and failure. Physiol Genomics. 2005 Sep 21; 23(1):18-27.
  11. Show all
  12. Perry ME, Mendrysa SM, Saucedo LJ, Tannous P, Holubar M. p76(MDM2) inhibits the ability of p90(MDM2) to destabilize p53. J Biol Chem. 2000 Feb 25; 275(8):5733-8.
  13. Forti F, Tannous P. [Immediate effects of cerebral gangliosides in peripheral neuropathies: electromyographic evaluation]. Arq Neuropsiquiatr. 1984 Dec; 42(4):356-61.
  14. Forti N, Barbato A, Forti F, Formícola A, Tannous P, Giannini SD. [Non-invasive evaluation of heart involvement in Steinert's disease]. Arq Bras Cardiol. 1980 Nov; 35(5):381-5.
To schedule an appointment: Call 617-355-8228


Boston Children’s is so much more than a hospital—it’s a community of researchers, clinicians, administrators, support staff, innovators, teachers, patients and families, all working together to make the impossible possible. ”
- Sandra L. Fenwick, President and CEO

Boston Children's Hospital
300 Longwood Avenue, Boston, MA 02115
For Patients: 617-355-6000
For Referring Providers: 844-BCH-PEDS | 844-224-7337