Melissa Hazen MD

Melissa Hazen, MD

Assistant in Medicine

Instructor

    Contact: 617-355-6117
  • Fax: 617-730-0249

Medical Services

Specialties

  • Multiple Manifestations of Autoimmune Disease
  • Inpatient Pediatrics
  • Immune Dysregulation and the Relationship between Immunodeficiency and Autoimmunity
  • Rheumatology Immunology Pediatrics

Departments

  • Rheumatology
To schedule an appointment: Call 617-355-6117

Experience and Education

Certifications

  • Pediatrics, Pediatric Rheumatology

Publications

Publications powered by Harvard Catalyst Profiles
  1. Hinks A, Bowes J, Cobb J, Ainsworth HC, Marion MC, Comeau ME, Sudman M, Han B, Becker ML, Bohnsack JF, de Bakker PI, Haas JP, Hazen M, Lovell DJ, Nigrovic PA, Nordal E, Punnaro M, Rosenberg AM, Rygg M, Smith SL, Wise CA, Videm V, Wedderburn LR, Yarwood A, Yeung RS, Prahalad S, Langefeld CD, Raychaudhuri S, Thompson SD, Thomson W. Fine-mapping the MHC locus in juvenile idiopathic arthritis (JIA) reveals genetic heterogeneity corresponding to distinct adult inflammatory arthritic diseases. Ann Rheum Dis. 2017 04; 76(4):765-772.
  2. Henderson LA, Volpi S, Frugoni F, Janssen E, Kim S, Sundel RP, Dedeoglu F, Lo MS, Hazen MM, Beth Son M, Mathieu R, Zurakowski D, Yu N, Lebedeva T, Fuhlbrigge RC, Walter JE, Nee Lee Y, Nigrovic PA, Notarangelo LD. Next-Generation Sequencing Reveals Restriction and Clonotypic Expansion of Treg Cells in Juvenile Idiopathic Arthritis. Arthritis Rheumatol. 2016 Jul; 68(7):1758-68.
  3. Boisson B, Laplantine E, Dobbs K, Cobat A, Tarantino N, Hazen M, Lidov HG, Hopkins G, Du L, Belkadi A, Chrabieh M, Itan Y, Picard C, Fournet JC, Eibel H, Tsitsikov E, Pai SY, Abel L, Al-Herz W, Casanova JL, Israel A, Notarangelo LD. Human HOIP and LUBAC deficiency underlies autoinflammation, immunodeficiency, amylopectinosis, and lymphangiectasia. J Exp Med. 2015 Jun 01; 212(6):939-51.
  4. Zenlea IS, Billett A, Hazen M, Herrick DB, Nakamura MM, Jenkins KJ, Woolf AD, Kesselheim JC. Trainee and program director perceptions of quality improvement and patient safety education: preparing for the next accreditation system. Clin Pediatr (Phila). 2014 Nov; 53(13):1248-54.
  5. Henderson LA, Frugoni F, Hopkins G, de Boer H, Pai SY, Lee YN, Walter JE, Hazen MM, Notarangelo LD. Expanding the spectrum of recombination-activating gene 1 deficiency: a family with early-onset autoimmunity. J Allergy Clin Immunol. 2013 Oct; 132(4):969-71.e1-2.
  6. Koyfman A, Lovallo E, Hazen MM, Chiang VW. A taste of periodic fever syndromes. Pediatr Emerg Care. 2013 Jul; 29(7):842-8; quiz 849-51.
  7. Kimura Y, Weiss JE, Haroldson KL, Lee T, Punaro M, Oliveira S, Rabinovich E, Riebschleger M, Antón J, Blier PR, Gerloni V, Hazen MM, Kessler E, Onel K, Passo MH, Rennebohm RM, Wallace CA, Woo P, Wulffraat N. Pulmonary hypertension and other potentially fatal pulmonary complications in systemic juvenile idiopathic arthritis. Arthritis Care Res (Hoboken). 2013 May; 65(5):745-52.
  8. Ercan A, Barnes MG, Hazen M, Tory H, Henderson L, Dedeoglu F, Fuhlbrigge RC, Grom A, Holm IA, Kellogg M, Kim S, Adamczyk B, Rudd PM, Son MB, Sundel RP, Foell D, Glass DN, Thompson SD, Nigrovic PA. Multiple juvenile idiopathic arthritis subtypes demonstrate proinflammatory IgG glycosylation. Arthritis Rheum. 2012 Sep; 64(9):3025-33.
  9. Ercan A, Cui J, Hazen MM, Batliwalla F, Royle L, Rudd PM, Coblyn JS, Shadick N, Weinblatt ME, Gregersen P, Lee DM, Nigrovic PA. Hypogalactosylation of serum N-glycans fails to predict clinical response to methotrexate and TNF inhibition in rheumatoid arthritis. Arthritis Res Ther. 2012 Mar 05; 14(2):R43.
  10. Tsuboi N, Ernandez T, Li X, Nishi H, Cullere X, Mekala D, Hazen M, Köhl J, Lee DM, Mayadas TN. Regulation of human neutrophil Fc? receptor IIa by C5a receptor promotes inflammatory arthritis in mice. Arthritis Rheum. 2011 Feb; 63(2):467-78.
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  12. Ercan A, Cui J, Chatterton DE, Deane KD, Hazen MM, Brintnell W, O'Donnell CI, Derber LA, Weinblatt ME, Shadick NA, Bell DA, Cairns E, Solomon DH, Holers VM, Rudd PM, Lee DM. Aberrant IgG galactosylation precedes disease onset, correlates with disease activity, and is prevalent in autoantibodies in rheumatoid arthritis. Arthritis Rheum. 2010 Aug; 62(8):2239-48.
  13. Hazen MM, Woodward AL, Hofmann I, Grom AA, Degar BA, Filipovich AH, Binstadt BA. . Mutations of the HLH-associated gene UNC13D (MUNC13-4) in a patient with systemic juvenile idiopathic arthritis. Arthritis and Rheumatism. 2008; 58:567-570.
  14. Hazen MM, Woodward AL, Hofmann I, Degar BA, Grom A, Filipovich AH, Binstadt BA. Mutations of the hemophagocytic lymphohistiocytosis-associated gene UNC13D in a patient with systemic juvenile idiopathic arthritis. Arthritis Rheum. 2008 Feb; 58(2):567-70.
  15. Hazen MM, Woodward AL, Hofmann I, Grom AA, Degar BA, Filipovich AH, Binstadt BA. Mutations of the HLH-associated gene UNC13D (MUNC13-4) in a patient with systemic juvenile idiopathic arthritis. American College of Rheumatology Annual Scientific Meeting. 2007.
  16. Fraia Melchionda, Terry J. Fry, Matthew J. Milliron, Melissa A. McKirdy, Yutaka Tagaya, and Crystal L. Mackall. Adjuvant IL-7 or IL-15 overcomes immunodominance and improves survival of the CD8+ memory cell pool. Journal of Clinical Investigation. 2005; 115:1177-1187.
  17. Fraia Melchionda; Melissa A. McKirdy; Filomena Medeiros; Terry J. Fry; Crystal L. Mackall . Escape from Immune Surveillance Does Not Result in Tolerance to Tumor-Associated Antigens. Journal of Immunotherapy. 2004; 27:329.
  18. Melissa M. Hazen. Characterization of the Immune Responses to the Tumor-Associated HY-Antigen. 2002.
  19. Fry, T.J., McKirdy, M.A., Mackall, C.L. . Progressive Tumor Growth in a Model Tumor Antigen System Does Not Induce Immunologic Tolerance but Appears to Induce Weak Immunity Toward Tumor Antigens. American Society of Hematology Meeting. 2001.
To schedule an appointment: Call 617-355-6117

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