Martha Sola-Visner, MD

Martha C. Sola-Visner, MD

Physician In Medicine; Director, Newborn Medicine Clinical Research Program

Associate Professor of Pediatrics, Harvard Medical School

  • Contact: 617-919-4845

  • Fax: 617-730-0260

Medical Services


  • Newborn Medicine


  • Medicine
  • Newborn Medicine


  • English
To schedule an appointment: Call 617-919-4845

Experience and Education


Medical School

School of Medicine, Santiago de Guayaquil Catholic University, 1992

Guayaquil, Ecuador

Neonatal-Perinatal Medicine Fellowship

University of Florida, Shands Teaching Hospital, 1997-2000

Gainesville, FL

Pediatrics Residency

University of Florida, Schands Teaching Hospital, 1994-1997

Gainesville, FL


  • Pediatrics, Neonatal-Perinatal Medicine


Publications powered by Harvard Catalyst Profiles
  1. Sparger KA, Assmann SF, Granger S, Winston A, Christensen RD, Widness JA, Josephson C, Stowell SR, Saxonhouse M, Sola-Visner M. Platelet Transfusion Practices Among Very-Low-Birth-Weight Infants. JAMA Pediatr. 2016 Jul 1; 170(7):687-94.
  2. Sola-Visner M, Bercovitz RS. Neonatal Platelet Transfusions and Future Areas of Research. Transfus Med Rev. 2016 Oct; 30(4):183-8.
  3. Jabara HH, Boyden SE, Chou J, Ramesh N, Massaad MJ, Benson H, Bainter W, Fraulino D, Rahimov F, Sieff C, Liu ZJ, Alshemmari SH, Al-Ramadi BK, Al-Dhekri H, Arnaout R, Abu-Shukair M, Vatsayan A, Silver E, Ahuja S, Davies EG, Sola-Visner M, Ohsumi TK, Andrews NC, Notarangelo LD, Fleming MD, Al-Herz W, Kunkel LM, Geha RS. A missense mutation in TFRC, encoding transferrin receptor 1, causes combined immunodeficiency. Nat Genet. 2016 Jan; 48(1):74-8.
  4. Arthur CM, Patel SR, Mener A, Kamili NA, Fasano RM, Meyer E, Winkler AM, Sola-Visner M, Josephson CD, Stowell SR. Innate immunity against molecular mimicry: Examining galectin-mediated antimicrobial activity. Bioessays. 2015 Dec; 37(12):1327-37.
  5. Christensen RD, Baer VL, Henry E, Snow GL, Butler A, Sola-Visner MC. Thrombocytopenia in Small-for-Gestational-Age Infants. Pediatrics. 2015 Aug; 136(2):e361-70.
  6. Liu ZJ, Bussel JB, Lakkaraja M, Ferrer-Marin F, Ghevaert C, Feldman HA, McFarland JG, Chavda C, Sola-Visner M. Suppression of in vitro megakaryopoiesis by maternal sera containing anti-HPA-1a antibodies. Blood. 2015 Sep 3; 126(10):1234-6.
  7. Sparger K, Deschmann E, Sola-Visner M. Platelet Transfusions in the Neonatal Intensive Care Unit. Clin Perinatol. 2015 Sep; 42(3):613-23.
  8. Debrincat MA, Pleines I, Lebois M, Lane RM, Holmes ML, Corbin J, Vandenberg CJ, Alexander WS, Ng AP, Strasser A, Bouillet P, Sola-Visner M, Kile BT, Josefsson EC. BCL-2 is dispensable for thrombopoiesis and platelet survival. Cell Death Dis. 2015; 6:e1721.
  9. Wallin DJ, Tkac I, Stucker S, Ennis KM, Sola-Visner M, Rao R, Georgieff MK. Phlebotomy-induced anemia alters hippocampal neurochemistry in neonatal mice. Pediatr Res. 2015 Jun; 77(6):765-71.
  10. Bender M, Thon JN, Ehrlicher AJ, Wu S, Mazutis L, Deschmann E, Sola-Visner M, Italiano JE, Hartwig JH. Microtubule sliding drives proplatelet elongation and is dependent on cytoplasmic dynein. Blood. 2015 Jan 29; 125(5):860-8.
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  12. Kulshrestha M, Sola-Visner M, Widness JA, Veng-Pedersen P, Mager DE. Mathematical model of platelet turnover in thrombocytopenic and nonthrombocytopenic preterm neonates. Am J Physiol Heart Circ Physiol. 2015 Jan 1; 308(1):H68-73.
  13. Shi DS, Smith MC, Campbell RA, Zimmerman PW, Franks ZB, Kraemer BF, Machlus KR, Ling J, Kamba P, Schwertz H, Rowley JW, Miles RR, Liu ZJ, Sola-Visner M, Italiano JE, Christensen H, Kahr WH, Li DY, Weyrich AS. Proteasome function is required for platelet production. J Clin Invest. 2014 Sep; 124(9):3757-66.
  14. Liu ZJ, Hoffmeister KM, Hu Z, Mager DE, Ait-Oudhia S, Debrincat MA, Pleines I, Josefsson EC, Kile BT, Italiano J, Ramsey H, Grozovsky R, Veng-Pedersen P, Chavda C, Sola-Visner M. Expansion of the neonatal platelet mass is achieved via an extension of platelet lifespan. Blood. 2014 May 29; 123(22):3381-9.
  15. Ferrer-Marin F, Gutti R, Liu ZJ, Sola-Visner M. MiR-9 contributes to the developmental differences in CXCR-4 expression in human megakaryocytes. J Thromb Haemost. 2014 Feb; 12(2):282-5.
  16. Köhler JR, Sola-Visner M. The silent crisis: children hurt by current immigration enforcement policies. JAMA Pediatr. 2014 Feb; 168(2):103-4.
  17. Deschmann E, Sola-Visner M, Saxonhouse MA. Primary hemostasis in neonates with thrombocytopenia. J Pediatr. 2014 Jan; 164(1):167-72.
  18. Ferrer-Marin F, Stanworth S, Josephson C, Sola-Visner M. Distinct differences in platelet production and function between neonates and adults: implications for platelet transfusion practice. Transfusion. 2013 Nov; 53(11):2814-21; quiz 2813.
  19. Sola-Visner M. Prognostic significance of low-grade intraventricular hemorrhage in the current era of neonatology. JAMA Pediatr. 2013 May; 167(5):487-8.
  20. Christensen RD, Yaish HM, Leon EL, Sola-Visner MC, Agrawal PB. A de novo T73I mutation in PTPN11 in a neonate with severe and prolonged congenital thrombocytopenia and Noonan syndrome. Neonatology. 2013; 104(1):1-5.
  21. Fuchs DA, McGinn SG, Cantu CL, Klein RR, Sola-Visner MC, Rimsza LM. Developmental differences in megakaryocyte size in infants and children. Am J Clin Pathol. 2012 Jul; 138(1):140-5.
  22. Cooper ST, Richters KE, Melin TE, Liu ZJ, Hordyk PJ, Benrud RR, Geiser LR, Cash SE, Simon Shelley C, Howard DR, Ereth MH, Sola-Visner MC. The hibernating 13-lined ground squirrel as a model organism for potential cold storage of platelets. Am J Physiol Regul Integr Comp Physiol. 2012 May 15; 302(10):R1202-8.
  23. Sallmon H, Sola-Visner M. Clinical and research issues in neonatal anemia and thrombocytopenia. Curr Opin Pediatr. 2012 Feb; 24(1):16-22.
  24. Sola-Visner M. Platelets in the neonatal period: developmental differences in platelet production, function, and hemostasis and the potential impact of therapies. Hematology Am Soc Hematol Educ Program. 2012; 2012:506-11.
  25. Liu ZJ, Sola-Visner M. Neonatal and adult megakaryopoiesis. Curr Opin Hematol. 2011 Sep; 18(5):330-7.
  26. Sola-Visner M. Cardiovascular disease and weight ... at birth. Blood. 2011 Aug 11; 118(6):1439-41.
  27. Cremer M, Sola-Visner M, Roll S, Josephson CD, Yilmaz Z, Bührer C, Dame C. Platelet transfusions in neonates: practices in the United States vary significantly from those in Austria, Germany, and Switzerland. Transfusion. 2011 Dec; 51(12):2634-41.
  28. Ferrer-Marin F, Chavda C, Lampa M, Michelson AD, Frelinger AL, Sola-Visner M. Effects of in vitro adult platelet transfusions on neonatal hemostasis. J Thromb Haemost. 2011 May; 9(5):1020-8.
  29. Liu ZJ, Italiano J, Ferrer-Marin F, Gutti R, Bailey M, Poterjoy B, Rimsza L, Sola-Visner M. Developmental differences in megakaryocytopoiesis are associated with up-regulated TPO signaling through mTOR and elevated GATA-1 levels in neonatal megakaryocytes. Blood. 2011 Apr 14; 117(15):4106-17.
  30. Josephson CD, Wesolowski A, Bao G, Sola-Visner MC, Dudell G, Castillejo MI, Shaz BH, Easley KA, Hillyer CD, Maheshwari A. Do red cell transfusions increase the risk of necrotizing enterocolitis in premature infants? J Pediatr. 2010 Dec; 157(6):972-978.e1-3.
  31. Ferrer-Marin F, Liu ZJ, Gutti R, Sola-Visner M. Neonatal thrombocytopenia and megakaryocytopoiesis. Semin Hematol. 2010 Jul; 47(3):281-8.
  32. Sallmon H, Gutti RK, Ferrer-Marin F, Liu ZJ, Sola-Visner MC. Increasing platelets without transfusion: is it time to introduce novel thrombopoietic agents in neonatal care? J Perinatol. 2010 Dec; 30(12):765-9.
  33. Hu Z, Slayton WB, Rimsza LM, Bailey M, Sallmon H, Sola-Visner MC. Differences between newborn and adult mice in their response to immune thrombocytopenia. Neonatology. 2010 Jun; 98(1):100-8.
  34. Poterjoy BS, Vibert Y, Sola-Visner M, McGowan J, Visner G, Nogee LM. Neonatal respiratory failure due to a novel mutation in the surfactant protein C gene. J Perinatol. 2010 Feb; 30(2):151-3.
  35. Osei-Bimpong A, Saleh M, Sola-Visner M, Widness J, Veng-Pedersen P. Correction for effect of cold storage on immature platelet fraction. J Clin Lab Anal. 2010; 24(6):431-3.
  36. Saxonhouse MA, Garner R, Mammel L, Li Q, Muller KE, Greywoode J, Miller C, Sola-Visner M. Closure times measured by the platelet function analyzer PFA-100 are longer in neonatal blood compared to cord blood samples. Neonatology. 2010; 97(3):242-9.
  37. Gerday E, Baer VL, Lambert DK, Paul DA, Sola-Visner MC, Pysher TJ, Christensen RD. Testing platelet mass versus platelet count to guide platelet transfusions in the neonatal intensive care unit. Transfusion. 2009 Oct; 49(10):2034-9.
  38. Bussel JB, Sola-Visner M. Current approaches to the evaluation and management of the fetus and neonate with immune thrombocytopenia. Semin Perinatol. 2009 Feb; 33(1):35-42.
  39. Sola-Visner M. Hematologic Issues. Introduction. Semin Perinatol. 2009 Feb; 33(1):1-2.
  40. Sola-Visner M, Sallmon H, Brown R. New insights into the mechanisms of nonimmune thrombocytopenia in neonates. Semin Perinatol. 2009 Feb; 33(1):43-51.
  41. Josephson CD, Su LL, Christensen RD, Hillyer CD, Castillejo MI, Emory MR, Lin Y, Hume H, Easley K, Poterjoy B, Sola-Visner M. Platelet transfusion practices among neonatologists in the United States and Canada: results of a survey. Pediatrics. 2009 Jan; 123(1):278-85.
  42. Brown RE, Rimsza LM, Pastos K, Young L, Saxonhouse MA, Bailey M, Lawrence RM, Sola-Visner MC. Effects of sepsis on neonatal thrombopoiesis. Pediatr Res. 2008 Oct; 64(4):399-404.
  43. Wiedmeier SE, Henry E, Sola-Visner MC, Christensen RD. Platelet reference ranges for neonates, defined using data from over 47,000 patients in a multihospital healthcare system. J Perinatol. 2009 Feb; 29(2):130-6.
  44. Flaumenhaft R, Dilks JR, Richardson J, Alden E, Patel-Hett SR, Battinelli E, Klement GL, Sola-Visner M, Italiano JE. Megakaryocyte-derived microparticles: direct visualization and distinction from platelet-derived microparticles. Blood. 2009 Jan 29; 113(5):1112-21.
  45. Christensen RD, Paul DA, Sola-Visner MC, Baer VL. Improving platelet transfusion practices in the neonatal intensive care unit. Transfusion. 2008 Nov; 48(11):2281-4.
  46. Slayton WB, Patel M, Sola-Visner M, Harris N, Rivers A, Montgomery RR, Friedman KD. Type 2B von Willebrand disease associated with the release of platelet agglutinates from megakaryocytes in the bone marrow. J Pediatr Hematol Oncol. 2008 Sep; 30(9):708-11.
  47. Sola-Visner M, Saxonhouse MA, Brown RE. Neonatal thrombocytopenia: what we do and don't know. Early Hum Dev. 2008 Aug; 84(8):499-506.
  48. Baer VL, Lambert DK, Henry E, Snow GL, Sola-Visner MC, Christensen RD. Do platelet transfusions in the NICU adversely affect survival? Analysis of 1600 thrombocytopenic neonates in a multihospital healthcare system. J Perinatol. 2007 Dec; 27(12):790-6.
  49. Li XM, Hu Z, Sola-Visner M, Hensel S, Garner R, Zafar AB, Wingard JR, Jorgensen ML, Fisher RC, Scott EW, Slayton WB. Sites and kinetics of donor thrombopoiesis following transplantation of whole bone marrow and progenitor subsets. Exp Hematol. 2007 Oct; 35(10):1567-79.
  50. Lambert MP, Rauova L, Bailey M, Sola-Visner MC, Kowalska MA, Poncz M. Platelet factor 4 is a negative autocrine in vivo regulator of megakaryopoiesis: clinical and therapeutic implications. Blood. 2007 Aug 15; 110(4):1153-60.
  51. Sola-Visner MC, Christensen RD, Hutson AD, Rimsza LM. Megakaryocyte size and concentration in the bone marrow of thrombocytopenic and nonthrombocytopenic neonates. Pediatr Res. 2007 Apr; 61(4):479-84.
  52. Ignatz M, Sola-Visner M, Rimsza LM, Fuchs D, Shuster JJ, Li XM, Jotwani A, Staba S, Wingard JR, Hu Z, Slayton WB. Umbilical cord blood produces small megakaryocytes after transplantation. Biol Blood Marrow Transplant. 2007 Feb; 13(2):145-50.
  53. Pastos KM, Slayton WB, Rimsza LM, Young L, Sola-Visner MC. Differential effects of recombinant thrombopoietin and bone marrow stromal-conditioned media on neonatal versus adult megakaryocytes. Blood. 2006 Nov 15; 108(10):3360-2.
  54. Christensen RD, Henry E, Wiedmeier SE, Stoddard RA, Sola-Visner MC, Lambert DK, Kiehn TI, Ainsworth S. Thrombocytopenia among extremely low birth weight neonates: data from a multihospital healthcare system. J Perinatol. 2006 Jun; 26(6):348-53.
To schedule an appointment: Call 617-919-4845


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